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Neutrophil-lymphocyte ratio in patients with ankylosing spondylitis

Ankilozan spondilit hastalarında nötrofil-lenfosit oranı

Journal Name:

  • Abant Tıp Dergisi

Publication Year:

  • 2014

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: The purpose of the present study is to determine the association between neutrophil-lymphocyte ratio (NLR) and inflammation in ankylosing spondylitis (AS). Method: Forty patients with ankylosing spondylitis and 30 healthy volunteers were included in the study. All data were obtained from patient registry database from in-patient and out-patient clinics. Detailed physical examination, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were recorded. Complete blood count (CBC), CRP and ESR were performed recorded as laboratory tests in all participants. Lymphocyte and neutrophil counts were measured as part of the automated CBC. Results: The CRP, which is an acute-phase reactant, and ESR were significantly higher in the patient group than those in the control group (p0.05). Conclusion: We observed that NLR levels weren’t significantly higher in AS patients compared to healthy individuals. NLR hasn’t seem a reasonable measure to detect systemic inflam-mation in AS patients. We believe that our preliminary results need to be complemented with further studies.
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Abstract (Original Language): 
Amaç: Bu çalışmanın amacı, ankilozan spondilit (AS) hasta-larındaki inflamasyon ile nötrofil-lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Ankilozan spondilit tanılı 40 hasta ve 30 sağlıklı gönüllü çalışmaya dahil edildi. Tüm veriler yatan ve polik-linik hasta kayıt veritabanından elde edildi. Tüm olguların Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BAS-DAI), tam kan sayımı (TKS), CRP ve ESH’ı da kapsıyan ayrın-tılı fizik muayene ve laboratuvar bulguları kaydedildi. Lenfosit ve nötrofil sayısı otomatik TKS’nin bir parçası olarak ölçüldü. Bulgular: Akut-faz reaktanı olan CRP ve ESH kontrol gru-buna göre hasta grubunda anlamlı olarak daha yüksekti (p 0.05). Sonuç: Bu çalışmada NLO düzeylerinin AS hastalarında sağlıklı bireylere göre anlamlı olarak yüksek olmadığı görüldü. Bu sonuç NLO’nun AS hastalarında sistemik inf-lamasyonu değerlendirmede uygun bir ölçü birimi olmadı-ğını götermektedir. Bizim elde ettiğimiz bu ön sonuçların daha ileri çalışmalarla tamamlanması gerektiğine inanıyo-ruz.
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