Journal Name:
- Advance Research in Pharmaceuticals and Biologicals
| Author Name | University of Author |
|---|---|
Abstract (2. Language):
The present study focuses on studying the effect of swelling capacity of Nimodipine Sustained release tablets such that
for all formulations it increases as increase the concentration of gum in each formulation. During the study it was
observed that drug release decreases with increasing concentration of gum and swelling index. The reason attributed to
this fact is formation of thick gel layer by matrices around tablets that delays diffusion and release drug. It was observed
that swelling index of matrix tablets containing only one natural polymer was less this may attributed to the lower water
uptake and less hydrophilicity. For all the ten formulations there was no occurrence of initial burst release, but the
release was constant in a controlled manner for a prolong period of time up to 12hrs. The initial release of drug from
these matrices occurs by the drug dissolution in the water penetrated into the matrix. The overall drug release from
these matrices is governed by hydration, gel layer formation and drug diffusion into the gel layer and to the dissolution
media. Polymer erosion also plays a major role in releasing drug from these matrices. . Swelling index of tablets
prepared from NMP5 resulted as better swelling behavior with respect to concentration.
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