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KOLOREKTAL KANSERDE METASTAZIN SERUM TOTAL SİYALİK ASİT DÜZEYLERİ ÜZERİNE ETKİSİ

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Abstract (2. Language): 
This study was designed to asses the effect of metastasis on serum total sialic acid level in patients with colorectal cancer. Results.- We measured serum total sialic acid (TSA) level by using Warren’s thiobarbituric acid assay. TSA levels in healthy control, colorectal cancer without metastasis and colorectal cancer with metastasis were found as 73.2 ± 6.0 ; 73.7 ± 5.0 ; and 96.0 ± 9.0 mg NANA/dL respectively. Statistical difference between metastasis and the other two groups was significant (p < 0.001). Conclusion.- According to our results, metastasis causes the increase of serum TSA levels. We suggest that the determination of this increase may be useful for the evaluation of a possible metastatic involvement.
Abstract (Original Language): 
Bu çalışmada Haydarpaşa Numune Eğitim Hastanesi 2. Dahiliye Kliniği’nde tanısı koyulmuş, 60 (36 erkek , 24 kadın) kolorektal kanser olgusu 20 kişiden oluşan sağlıklı kontrol grubu ile serum TSA düzeyleri bakımından karşılaştırılmıştır. TSA düzeyleri Warren’in tiobarbitürik asid yöntemine göre ölçülüp, kontrol grubu, metastazı olmayan kolorektal kanser ve metastazlı grup için sırasıyla 73,2 ± 6,0; 77,60 ± 5,0 ve 96,0 ± 9,0 mg NANA/ dL olarak bulunmuştur . Kontrol grubu ile metastazı olmayan grup arasında istatistiksel olarak anlamlı bir farklılık bulunmazken (p > 0,05) , metastazlı grupta her iki gruba göre anlamlı düzeyde artışlar saptandı (p < 0,001). Elde ettiğimiz bulgulara göre metastaz serum TSA düzeylerinin artışına neden olmaktadır. Bu artışın saptanmasının olas ı bir metastaz varlığını değerlendirmede faydalı olabileceği kanısındayız.
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