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Oligospermik İnfertil Bir Erkekte Resiprokal Translokasyon t(1;5)(p33;qter)

Reciprocal Translocation T(1;5)(P33;Qter) in aq Oligospermic Infertile Male

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2009

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Infertility affects an estimated 15% of couples and in roughly half of cases male-related factors are involved, frequently associated with impaired spermatogenesis, e.g. oligospermia or azoospermia. The incidence of somatic chromosome anomalies in infertile male patients hase been reported between 2.2 and 19.6%. In this study, we present the results of a cytogenetic analysis performed on a couple, who were referred to our laboratory due to infertility. We found a normal karyotype (46,XX) in female, and balanced reciprocal translocation [46,XY,t(1;5)(p33;qter)] in the male. We deduced that chromosomal rearrangements in this case were caused infertility due to the interference with spermatogenesis
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Abstract (Original Language): 
İnfertilite, çiftlerin yaklaşık %15'ini etkilemekte olup erkek faktörlü vakaların yaklaşık olarak yarısı oligospermi, azospermi gibi hatalı spermatogenezle ilişkilidir. İnfertil erkek hastalarda somatik kromozom anomali insidansının %2.2 ve 19.6 arasında olduğu rapor edilmiştir. Bu çalışmamızda, infertilite nedeniyle laboratuvarımıza gönderilen çiftte yapılan sitogenetik analiz sonuçları sunulmuştur. Kadında normal karyotip (46,XX), erkekte dengeli resiprokal translokasyon [46,XY,t(1;5)(p33;qter)] belirlenmiştir. Olguda var olan kromozomal düzensizliğin spermatogenezisi etkileyerek infertiliteye neden olduğu sonucuna vardık.
FULL TEXT (PDF): 
PDF icon arastrmx_135291_14_pp_204-206.pdf
  • 3
204-206
  • Turkish

REFERENCES

References: 

1.
205
Fırat Tıp
Dergis
i 2009;14(3): 204-206
3. Egozcue S, Blanco J, Vendrell JM, et al. Human male infertility: chromosome anomalies, meiotic disorders, abnormal spermatozoa and recurrent abortion. Hum Reprod Update 2000;
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Erol ve Yüce
6. Sazci A, Ercelen N, Ergul E, Akpinar G. Male factor infertility associated with a familial translocation t(1;13)(q24;q10). Fertil Steril 2005; 83(5):1548-50.
7. Mark HF, Sigman M. Male infertility associated with a unique 8;22 translocation. Exp Mol Pathol 1999; 67(1):57-61.
8. Lorda-Sanchez I, Tejedor C, Sanz R, Rodriguez de Alba M, de la Fuente A, Fernandez E, Ayuso C, Ramos C. A maternal inherited translocation t(1;22)(q11;p11) in two infertile brothers. Genet Couns 2001; 12(1):95-100.

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