Carcinosarcoma of Breast: A report of triple positive variant

Journal Name:

Publication Year:

Abstract (2. Language): 
Carcinosarcoma of the breast is an exceedingly rare andaggressive tumour with exiguous prognosis.This tumour has theepithelial and mesenchymal components derived from two diverse cell lines.They are arduous to diagnose both preoperatively and postoperatively.Differential staining with cytokeratin, vimentin and lack of transition between the two components of the tumouraids in clinching the diagnosis. Attaining negative surgical margins either by radical or breast conserving procedures remain the gold standard in management. Carcinosarcoma of the breast with triple receptor positive phenotype are inimitable. Adjuvant therapy should be tailored to the immuno-histochemical signature of the individual tumours.A careful periodic follow-upis vital to detect metastasis and recurrence early and to minimize mortality.We hereby report a case of carcinosarcoma of the breast with triple positive phenotype because of its rarity and prognostic importance.



1. Gupta V, Sharma J, Garg S, Hasija S, Goyal R, Sangwaiya A, Sen R. Carcinosarcoma of Breast: A
Rare tumor with Triple Positive Phenotype. SEAJCRR. (2014); 3(2): 628-633
2. Rosen, Peter Paul: Carcinoma with metaplasia. In Rosen's Breast Pathology Third edition.
Philadelphia: Lippincott Williams & Wilkins; 2009:470-474
3. Rosai J: Special techniques in surgical pathology. Rosai and Ackerman's Surgical Pathology, Mosby
Ninth edition. 2004;1810-1812
4. Luini A, Aguilar M, Gatti G, Fasani R, Botteri E, Brito JA, et al. Metaplastic carcinoma of the breast,
an unusual disease with worse prognosis: The experience of the European Institute of Oncology and
review of the literature. Breast Cancer Res Treat 2007;101:349-5. PubMed ID:17009109
5. Ayar S, Dysee L, Carter E. Matrix-producing carcinoma: A rare variant of metaplastic breast
carcinoma with heterologous elements. Breast J 2010;16:420. DOI: 10.1111/j.1524-
6. Hennessy BT, Giordano S, Broglio K, Duan Z, Trent J, Buchholz TA, Babiera G, et al. Biphasic
metaplastic sarcomatoid carcinoma of the breast. Ann Oncol 2006;17(4):605-613.
DOI: 10.1007/s12282-008-0091-7
7. Geyer, F. C., Weigelt, B., Natrajan, R., Lambros, M. B., de Biase, D., Vatcheva, R., Savage, K.,
Mackay, A., Ashworth, A. and Reis-Filho, J. S. Molecular analysis reveals a genetic basis for the
phenotypic diversity of metaplastic breast carcinomas. J. Pathol (2010); 220: 562–573.
doi: 10.1002/path.2675. DOI: 10.1002/path.2675
8. Velasco M, Santamaría G, Ganau S, Farrús B, Zanón G, Romagosa C, et al. MRI of metaplastic
carcinoma of the breast. Am J Roentgenol 2005; 184:1274–1278. PubMed ID:15788609
Indian Journal of Basic and Applied Medical Research; December 2014: Vol.-4, Issue- 1, P. 110-116
www.ijbamr.com P ISSN: 2250-284X , E ISSN : 2250-2858
9. Hoda SA, Rosen PP. Observations on the pathologic diagnosis of selected unusual lesions in needle
core biopsies of breast. Breast J 2004;10:522–527. DOI: 10.1111/j.1075-122X.2004.21412.x
10. Tokudome N, Sakamoto G, Sakai T, Sarumaru S, Okuyama N, Hori F, Horii R, Akiyama F, Tanabe
M, Saito K, Takahashi K, Kasumi F. A case of carcinosarcoma of the breast. Breast Cancer
2005;12:149–153. PubMed ID:15858448
11. Leibl S, Moinfar F. Metaplastic breast carcinomas are negative forHer-2 but frequently express
EGFR (Her-1): potential relevance toadjuvant treatment with EGFR tyrosine kinase inhibitors? J Clin
Pathol 2005;58:700–704. DOI:10.1136/jcp.2004.025163
12. Y. W. Lum and L. Jacobs, “Primary breast sarcoma,” Surgical Clinics of North America2008, vol.
88, no. 3, pp. 559–570. DOI: 10.1016/j.suc.2008.03.009
13. Wada H, Enomoto T, Tsujimoto M, Nomura T, Murata Y, Shroyer KR: Carcinosarcoma of the
breast: molecular-biological study for analysis of histogenesis. Hum Pathol 1998;29:1324–1328.
DOI: 10.1016/S0046-8177(98)90266-0
14. S. A. Vorburger, Y. Xing, K. K. Hunt et al., “Angiosarcoma of thebreast,” Cancer 2005, vol. 104, no.
12, pp. 2682–2688. DOI: 10.1002/cncr.21531

Thank you for copying data from http://www.arastirmax.com