Buradasınız

Yaşa Bağlı Makula Dejenerasyonunda Fotodinamik Tedavi

Photodynamic Therapy For Age-Related Macular Degeneration

Journal Name:

Publication Year:

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Photodynamic therapy is based on the ablation of choroidal neovascular membranes using intravenous verteporfin and low-power diode laser treatment. In this review, we focused on using photodynamic therapy for AMD because it is a new treatment which has recently been proved in large scale, randomised clinical trials to reduce the risk of vision loss in selected cases of AMD with CNV that extend under the centre of the foveal avascular zone.
Abstract (Original Language): 
Fotodinamik tedavi düşük güçlü diyod lazer tedavisi ve intravenöz Verteporfin ile koroidal neovasküler membranların ablase edilmesi esasına dayanır. Hedeflenen bölgede ilacın spesifik aktivasyonu sistemik yan etkilerden kaçınılmasını sağlar. Bu çalışmada fotodinamik tedavinin özellikle yaşa bağlı makuler dejenerasyondaki kullanımı üzerinde durulmuştur, çünkü fotodinamik tedavi foveal avasküler bölgenin merkezinin altını tutan koroidal neovasküler membranlı seçili yaşa bağlı makula dejenerasyonu olgularında görme kaybı riskini azaltmak amacıyla büyük klinik çalışmalara konu olan güncel bir tedavidir.
109-114

REFERENCES

References: 

1. Smyth RJ, Nguyen K, Ahn SS, et al. The effects of photophrin on human Tenon's capsule fibroblasts in vitro. J Ocular Pharmacol 1993;9:171-8.
2. Jampel HD, Jabs DA, Quigley HA. Trabeculectomy with 5-fluorouracil for adult
inflammatory glaucoma. Am J Ophthalmol 1990;109:168-73.
3. Dougherty TJ, Marcus SL. Photodynamic therapy. Eur J Cancer 1992;28:1734-42.
4. Weissgold DJ, Hu LK, Gragoudas ES, et al. Photodynamic therapy (PDT) of pigmented choroidal melanoma via a trans-scleral approach. Invest Ophthalmol Vis Sci 1996;37:(S)123. (Abstract no 588.)
5. Moshfeghi DM, Peyman GA, Khoobehi B, et al. Photodynamic occlusion of retinal vessels using tin ethyl etiopurin (SnET2): an efficacy study. Invest Ophthalmol Vis Sci 1995;36:(S)115. (Abstract no 564.)
6. Cox KW, Shepperd JD, Lattanzio FA, et al. Photodynamic therapy of corneal neovascularization using topical dihematoporphyrin ester. Invest Ophthalmol Vis Sci 1997;38:(S)512. (Abstract no 2369.)
7. Dacheux R, Guidry C. Cellular photoablation as a therapy to control proliferative vitreoretinopathy: in vitro studies. Invest Ophthalmol Vis Sci 1995;36:(S)751.
(Abstract no 3476.)
8. Hill RA, Crean DH, Doiron DR, et al. Photodynamic therapy for antifibrosis in a rabbit model of filtration surgery. Ophthalmic Surg Lasers 1997;28:574-81
9. Manyak MJ, Russo A, Smith PD, et al. Photodynamic therapy. J Clin Oncol
1988;6:380-91.
10. Husain D, Miller JW. Photodynamic therapy of exudative age-related macular degeneration. Sem Ophthalmol 1997;12:14-25.
11. Roberts WG, Hasan T. Role of neovasculature and vascular permeability on the tumor retention of photodynamic agents. Cancer Res 1992;52:924-30.
12. Zhou C. Mechanisms of tumor necrosis induced by photodynamic therapy. J
Photochem Photobiol B 1989;3:299-318.
13. Ciulla TA, Danis RP, Haris A. Age-related macular degeneration: a review of experimental treatments. Surv Ophthalmol 1998; 43: 134-46.
14. Soubrane G, Bressler NM. Treatment of subfoveal choroidal neovascularisation in age-related macular degeneration-focus on clinical application of verteporfin
photodynamic therapy. Br J Ophthalmol 2001; 85: 483-95.
15. Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal neovascular lesions of age-related macular degeneration. Resuts of a randomized
clinical trial. Arch Ophthalmol 1991; 109: 1220-31.
16. Schimidt-Erfurth U, Hasan T, Gragoudas E, Michaud N, Flotte TJ, Birngruber R Vascular targeting in photodynamic occlusion of subretinal vessels. Ophthalmology
1994; 101: 1953-61.
17. Allison BA, Pritchard PH, Levy JG. Evidence for low-density lipoprotein receptor-mediated uptake of benzoporphyrin derivative. Br J Cancer 1994;69:833-39.
18. Schmidt-Erfurth U, Hasan T, Schomacker K, et al. In vivo uptake of liposomal benzoporphyrin derivative and photothrombosis in experimental corneal neovascularization. Lasers Surg Med 1995;17:178-88.
19. Richter AM, Kelly B, Chow J, et al. Preliminary studies on a more effective phototoxic agent than hemotoporphyrin. J Natl Cancer Inst 1987; 79: 1327-32.
20. Levy JG, Chan A, Strong HA. The clinical status of benzoporphyrin derivative. SPIE
1996; 2625: 86-95.
21. Husain D, Miller JW, Michaud N, et al. Intravenous infusion of liposomal benzoporphyrin derivative for photodynamic therapy of experimental choroidal
neovascularization. Arch Ophthalmol 1996;114:978-85.
22. Schmidt-Erfurth U, Birngruber R, Hasan T. Photodynamic therapy in ocular vascular
disease. Laser Physics 1998;8:191-8.
23. Aveline B, Hasan T, Redmond RW. Photophysical and photosensitizing properties of benzoporphyrin derivative monoacid ring A (BPD-MA). Photochem Photobiol
1994;59:328-35.
24. Husain D, Kramer M, Michaud N, et al. Photodynamic therapy (PDT) of experimental choroidal neovascularization (CNV) using benzoporphyrin derivative (BPD-MA): dye delivery and treatment parameters. Invest Ophthalmol Vis Sci
1995;36:S225.
25. Gaffney J, West D, Arnold F, et al. Differences in the uptake of modified low density lipoproteins by tissue cultured endothelial cells. J Cell Sci 1985;79:317-25.
26. Fogelman AM, Berliner JA, Van Lenten BJ, et al. Lipoprotein receptors and
endothelial cells. Sem Thromb Hemost 1988;14:206-9.
27. Kramer M, Kenney AG, Delori F, et al. Imaging of experimental choroidal neovascularization (CNV) using liposomal benzoporphyrin derivative mono-acid
(BPD-MA) angiography. Invest Ophthalmol Vis Sci 1995;36:S236.
28. Schmidt-Erfurth U, Bauman W, Gragoudas E, et al. Photodynamic therapy of experimental choroidal melanoma using lipoprotein-delivered benzoporphyrin.
Ophthalmology 1994;101:89-99.
29. Haimovici R, Kramer M, Miller JW, et al. Localization of lipoprotein-delivered benzoporphyrin derivative in the rabbit eye. Curr Eye Res 1997;16:83-90.
30. Kramer M, Miller JW, Michaud N, et al. Liposomal benzoporphyrin derivative verteporfin in photodynamic therapy. Selective treatment of choroidal neovascularization in monkeys. Ophthalmology 1996;103:427-38.
31. Schmidt-Erfurth U, Hasan T. Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. Surv Ophthalmol 2000; 45: 195-214.
32. Scott LJ, Goa KL. Verteporfin. Drugs and Ageing 2000; 16(2): 139-47.
33. Schmidt-Erfurth U, Hasan T, Flotte T, et al. Photodynamic therapy of experimental intraocular melanoma using benzoporphyrin lipoprotein. Ophthalmologe
1994;91:348-56.
34. Miller JW, Walsh AW, Kramer M, et al. Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-delivered benzoporphyrin. Arch
Ophthalmol 1995;113:810-18.
35. Husain D, Kramer M, Kenny AG, et al. Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7 weeks after treatment. Invest Ophthalmol Vis Sci 1999;40:2322-31.
36. Reinke MH, Canakis C, Husain D, et al. Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey. Ophthalmology
1999;106:1915-23.
37. Miller JW, Schmidt-Erfurth U, Sickenberg M, et al. Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration. Results of a single treatment in a phase 1 and 2 study. Arch Ophthalmol
1999;117:1161-73.
38. Schmidt-Erfurth U, Miller JW, Sickenberg M, et al. Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration. Results of retreatments in a phase 1 and 2 study. Arch Ophthalmol
1999;117:1177-87.
39. Treatment of Age-related Macular Degeneration With Photodynamic Therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. One-year results of 2 randomized clinical trials TAP Report 1. Arch Ophthalmol 1999;117:1329-45.
40. Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. Two-year results of 2 randomized clinical trials- TAP Report Arch Ophthalmol 2001; 119: 198-207.
41. Kostenich G, Orenstein A, Roitman L, et al. In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system. J Photochem Photobiol B 1997;39:36-42.
42. Graham KB, Arbour JD, Connolly EJ, et al. Digital angiography using lutetium texaphyrin in a monkey model of choroidal neovascularization. Invest Ophthalmol Vis Sci 1999;40:S402.
43. Primbs GB, Casey R, Lin GC, et al. Photodynamic therapy of corneal neovascularization using tin ethyl etiopurpurin (SnET2). Invest Ophthalmol Vis Sci
1997;38:S702.
44. Thomas EL, Rosen R, Murphy R, et al. Purlytin (SnET2)-photodynamic therapy produces closure of subfoveal choroidal neovascularization in humans. Invest
Ophthalmol Vis Sci 1998;39:S242.
45. Thomas EL, Rosen R Murphy R et al. Visual acuity stabilizes after a single treatment with SnET2 photodynamic therapy in patients with subfoveal choroidal
neovascularization. Invest Ophthalmol Vis Sci 1999;40:S401.
46. Moshfeghi DM, Peyman GA, Kazi AA, et al. Mono-L-aspartyl chlorin e6 (NPe6) angiography of the retina in pigmented rats, rabbits, and monkeys. Invest Ophthalmol
Vis Sci 1999;40:S322.
47. Wong Kee Song L-M, Wang KK, Zinsmeister AR Mono-L-aspartyl chlorin e6 (Npe6) and hematoporphyrin derivative (HpD) in photodynamic therapy administered to a human cholangiocarcinoma model. Cancer 1998;82:421-7.

Thank you for copying data from http://www.arastirmax.com