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Swiss Albino Farelerde Alkol ve Sigaranin Testis Dokusu Üzerine Etkileri

Effects of Alcohol and Passive Cigarette Smoking on the Swiss Albino Mice Testes

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2004

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Abstract (2. Language): 
Aim: The aim of this study, was to investigate the effects of alcohol, passive smoking and alcohol+passive smoking on the testicular morphology of the adult Swiss albino mice. Method: 32 male Swiss albino mice were used in this study. The animals were divided randomly in to four groups (n1=...n4=8): one group served as the control group, and the others were subjected to either alcohol, passive smoking or alcohol + passive smoking for 6 weeks. Results: No differences were found in absolute or relative testis weights among the different groups. The mean seminiferous tubule diameter was gradually decreased in passive smoking, alcohol and alcohol + passive smoking groups when compared with control group. We found a statistically significant difference between control and alcohol + passive smoking groups (p=0,006), alcohol and passive smoking groups (p=0,005), and passive smoking and alcohol + passive smoking groups (p=0,004). Seminiferous tubules containing degenerated germinal epithelium and decrease in number of Leydig cells were observed in a few tubules of testes from passive smoking and alcohol groups. Degenerative changes were more severe in the group exposed to both alcohol and cigarette smoke. Conclusion: In the present study, it was observed that alcohol, passive smoking and alcohol + passive smoking caused injury in testis tissue of Swiss albino mice and that these changes were more severe in alcohol + passive smoking group.
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Abstract (Original Language): 
Amaç: Sunulan araştırma, erişkin erkek Swiss albino farelerde uzun süreli alkol, pasif sigara, alkol+pasif sigara kombinasyonunun testis dokusuna etkilerini ortaya koymak amacıyla yapılmıştır. Gereç ve Yöntem: Çalışmada 32 adet erişkin erkek Swiss albino fare kullanıldı. Fareler dört eşit gruba ayrıldı (n1=...n4=8). Kontrol grubuna herhangi bir işlem uygulanmazken deney gruplarındaki hayvanlar altı hafta boyunca alkol, pasif sigara ve alkol+pasif sigaraya maruz bırakıldı. Bulgular: Gruplar arasında total veya nisbi testis ağırlıklarında fark gözlenmedi. Ortalama seminifer tübül çaplarının kontrol grubu ile karşılaştırıldığında pasif sigara, alkol ve alkol+pasif sigara gruplarında giderek azaldığı görüldü. Bu azalma kontrol ile alkol grupları arasında (p=0,02); kontrol ile alkol+pasif sigara grupları arasında (p=0,006); alkol ile pasif sigara grupları arasında (p=0,005); pasif sigara ile alkol+pasif sigara grupları arasında (p=0,004) istatistiksel olarak anlamlı bulundu. Kesitler mikroskopik olarak incelendiğinde pasif sigara ve alkol grubundaki bazı kesitlerde seminifer tübül epitelinde yer yer dejenerasyon ve Leydig hücrelerinde artma gözlendi. Alkol+pasif sigara grubunda seminifer tübül duvarındaki dejeneratif değişikliklerin daha fazla olduğu gözlendi. Sonuç: Sunulan araştırmada alkol, pasif sigara ve alkol+pasif sigara uygulamasının farelerin testis dokusunda hasara neden olduğu ve alkol+pasif sigara uygulaması yapılan grupta bu değişikliklerin daha belirgin olduğu tespit edildi.
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