Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
Key Words:
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Abstract (2. Language):
Objectives:
To evaluate the anti-asthmatic activity Hiptage benghalensis (L) Kurzz leaves on early and late phase of asthma in various experimental animal models.
An Anti-asthmatic activity of Hiptage benghalensis (L) Kurzz leaves was studied on Total leukocytes Counts (TLC) and Differential Leukocyte Counts (DLC) using bronchoalveolar lavaged (BAL) fluid of guinea pigs sensitized by egg albumin and PAF acether. Study was also conducted for same in ketotifen treated group which was taken as standard for comparison of anti-asthmatic activity.
Treatment with Hiptage benghalensis for 15 days resulted in significant decrease in Total Leukocytes Count (TLC) as well as Differential Leukocytes Count (DLC) in BAL fluid of guinea pigs sensitized by egg albumin and PAF acether. It was comparable to standard drug ketotifen Fumarate.
Hiptage benghalensis (L) Kurzz inhibits the migration of leukocytes on exposure to antigens in early stage (Egg albumin sensitized, by I.V. route) as well as in late phase (PAF acether sensitized, by aerosol route) of asthma, thus conforming its anti-allergic activity in actively as well as passively se nsitized condition. So it was concluded that Hiptage benghalensis (L) Kurzz have anti-asthmatic ac tivity on both early as well as late stage of asthma.
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