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A REVIEW ON LATEST DEVELOPMENTS IN THE STANDARDIZATION OF AYURVEDIC DRUGS

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Abstract (2. Language): 
Standardization of Ayurvedic formulations is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. WHO specific guidelines for the assessment of the safety, efficacy and quality of herbal medicines as a prerequisite for global harmonization are of utmost importance. An overview covering various techniques employed in extraction and characterization of herbal medicines as well as herbal Nano medicines standardization is reported. In addition, phytosomes increased bioavailability, bhasma as a metal Nano carrier drug delivery system, potential of metabolomics in the development of improved phytotherapeutic agents, DNA based molecular markers in distinguishing adulterants, and SCAR markers for authentication and discrimination of herbs from their adulterants are reported. Processed metals including Mercury, Gold, Silver, Lead, Zi nc, Copper etc. were used very frequently by seers of the Indian tradition in different disease conditions with great authority. Recent advances in the study of minerals include petrological studies to analyze the physical and chemical changes in particular

REFERENCES

References: 

1. Gautam V, Raman RM, Ashish K: Exporting Indian healthcare (Export potential of Ayurveda and Siddha products and services) Road beyond boundaries (The case of selected Indian healthcare systems).Gautam V, Raman RMV, Ashish K. (eds.) Export-Import Bank of India 2003:
4-54.
2. Sagar Bhanu PS, Zafar R and Panwar R: Herbal drug standardization. The Indian
Pharmacist 2005; 4(35):19-22.
3. P.S.Mukherjee: Quality control of herbal drugs, second edition. 455- 456.
4.http://www.reddybams.page.tl/MALLASI NDHUR.htm (Accessed 12th April 2012).
5. Krishna gopal shastri, Rasendrasara sangraha, 1/157-158, Ajmer: Krishna gopal ayurved bhavan, kaleda. 2006: 59.
6. Kokate CK and Purohit AP: Nirali
Prakashan, text book of pharmacognosy, 34th edition: 97-132.7. Dixit Renu and Reddy Vijay: Rasaushadha standardization and analysis-ancient and recent approach. International conference on recent advances in safety and efficacy of ayurvedic formulation 2011: 134.
8. Achrya Daulat Ram Shastri, Rasa Hardiya Tantra, Chaukhamba publishers Varanasi.2001
9.Sachan V, Kohli Y and Gautam R: Regulatory issues for herbal products - a review. Pharmainfo.net, http://www.pharmainfo.net/justvishal/public ations/regulatoryissues-herbal-products-review. (Accessed 12th April 2012).
10. Ray A and Gulati K: Recent advances in herbal drug research and therapy. I K International. 2010: 23-25.
11. Agarwal SS and Paridhavi M: Herbal drug technology, Universities Press India
Pvt Ltd, 2007.
12. Zafar R, Panwar R and Sagar Bhanu PS: Herbal drug standardization: The Indian
Pharmacist 2005; 4: 21-25.
13. Patra KC, Pareta SK, Harwansh RK and Jayaram Kumar K: Traditional approaches towards standardization of herbal medicines -A review. J Pharm Sci Technol. 2010; 2:
372-379.
14. Straus SE. Herbal remedies. New Engl J
Med 2002; 347: 2046-2056.
15. Sharma AK, Gaurav SS and Balkrishna A: A rapid and simple scheme for the standardization of polyherbal drugs. Int J
Green Pharm 2009; 3:134-140.
16. Satheesh Madhav NV, Kumud
Upadhyaya and Bisht A: Phytochemical screening and standardization of polyherbal formulation for dyslipidemia. Int J Pharm Pharmaceut Sci. 2011; 3: 56-59.
17. Patwardhan B. A method of treating musculoskeletal disease and a novel composition there of US Patent 5494668,
1996.
18. Chandel HS, Pathak AK and Tailang M:
Standardization of some herbal antidiabetic drugs in polyherbal formulation. J
Pharmacog Res 2011; 3:49-56.
19. Sanjay J, Sweta S, Rakesh B and Praveen K: Standardization of 'Dashamularishta' A polyherbal formulation. Pharmacog J. 2009; 1(3): 54¬57.
20. Kumar T, Chandrashekar KS, Tripathi DK, Nagori K, Pure S and Agrawal S: Standardization of "Gokshuradi Churna" Anayurvedic polyherbal formulation. J Chem
Pharm Res 2011; 3(3): 742-749.
21. Rajani M and Kanaki NS: Phytochemical standardization of herbal drugs and polyherbal formulations. Bioactive Molecules and Medicinal Plants, (Ramawat KG, Merillon JM (Eds.) Springer
2008; 349-369.
22. Ahmad I, Aqil F and Owais M: Turning medicinal plants into drugs. Modern
Phytomed 2006; 384:67-72.
23. Rajurker S, Rekhe DS, Maini S and Ravikanth K: Acute toxicity studies of polyherbal formulation (Methiorep Premix). Vet World 2009; 2(2): 58-59.
24. Pattanaya P, Jena RK and Panda SK: HPTLC fingerprinting in the standardization of sulaharan yoga: An ayurvedic tablet formulation. Int J Pharm Sci Rev Res 2010;
3(2): 33-36.
25. Shikha S and Mishra N: Genetic markers - a cutting-edge technology in herbal drug research. J Chem Pharm Res 2009; 1:1-18.
26. Lazarowych NJ and Pekos P: The use of fingerprint and marker compounds for identification and standardization of botanical drugs. J Drug Inform 1998; 32:
497-512.
27. Kalpana J, Preeti C, Dnyaneshwar W and Bhushan P: Molecular markers in herbal drug technology. Curr Sci 2004; 87: 159¬165.
28. Jayvant K, Vaibhav S and Abhay H: Application of ISSR marker in pharmacognosy. Curr Sci 2009; 3: 216-228.
29. Chandrakant K., Dere Pravin J., Honde Bharat S,.Kothule Sachin and Kote Amol P: An overview of supercritical fluid extraction for herbal drugs, Pharmacologyonline 2011;
2: 575-596.
30. VyasN , Khan MY, Panchal S, Butani A,
Kumar V. Supercritical fluid technology-An unlimited frontier in herbal research. Int J
Pharm Sci Nanotechnol 2009; 1(4): 303¬307.
31. Bertucco A, Franceschin G. Supercritical fluid extraction of medicinal and aromatic plants: Fundamentals and applications. In: Extraction technologies for medicinal and aromatic plants. International Centre for Science and High Technology. Trieste,
2008.
32. Wang Y, Xi GS, Zheng YC and Miao FS: Microwave-assisted extraction of flavonoids from Chinese herb Radix puerariae. J Med Plant Res 2010; 4(4): 304¬308.
33. Be'atrice K and Philippe C: Recent extraction techniques for natural products: Microwave-assisted extraction and pressurised solvent extraction. Phytochem Anal 2002; 13:105-113. Vivekananda M, Yogesh M, Hemalatha S. Microwave assisted extraction - An innovative and promising extraction tool for medicinal plant research. J Pharmacog Rev 2007; 1(1): 78¬84.
34. Yan Z, Feng D, Li S, Zhao Y and Yang H: Determination of organ chlorine pesticide residues in nine herbs by solidphase extraction and capillary gas
chromatography. Se Pu. 2005; 23(3):308-311.
35. Lee MC, Tsao CH, Iou SC, Chuang WC
and Sheu SJ: Analysis of aristolochic acids in herbal medicines by LC/UV and LC/MS.
J Sep Sci 2003; 26:818-822.
36. Shalini S and Roy RK: Phytosomes: an emerging technology. Int J Pharm Res Dev
2010; 2:14 15
37. Bhattacharya S and Ghosh A: Phytosomes: the emerging technology for enhancement of bioavailability of botanicals
and nutraceuticals. Int J Aesthetic &
Antiaging Med 2009; 2 (1):87-91.
38. Bhattacharya S and Ghosh A: Phytosomes: the emerging technology for enhancement of bioavailability of botanicals and nutraceuticals. Int J Aesthetic &
Antiaging Med 2009; 2 (1):87-91.
39. Jagruti P, Rakesh P, Kapil K and Nirav P: An overview of phytosomes as an advanced herbal drug delivery system Asian J Pharma Sci 2009; 4(6): 363-371.
40. Kidd PM: Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Alternative
Med Rev 2009; 14(3): 226-46.
41. Chimezie A, Ibukun A, Teddy E and Francis O: HPLC analysis of nicotinamide, pyridoxine, riboflavin and thiamin in some selected food products in Nigeria. Afr J
Pharm Pharmacol 2008; 2(2): 29-36.
42. Rao Udaykumar B and Anna NP: Stability- indicating HPLC method for the determination of efavirenz in bulk drug and in pharmaceutical dosage form. Afr J Pharm
Pharmacol 2009; 3(12): 643-650.
43. Anupam S, Krishan L, Handa SS. Standardization: HPLC determination of vasicine in polyherbal formulations. Pharm
Biol 1992; 30(3): 205-208.
44. Demirezer O, Karahan N, Ucakturk E, Kuruuzum-Uz A, Guvenalp Z and Kazaz C: HPLC fingerprinting of sennosides in laxative drugs with isolation of standard substances from senna leaves. J Nat Prod
2011; 5(4): 261-270.
45. Singh DP, Govindarajan R and Rawat AKS: High-performance liquid chromatography as a tool for the chemical standardization of Triphala an ayurvedic formulation Phytochem Anal 2007;
19(2):164-168.
46. Zhang Q and Ye M: Chemical analysis of the Chinese herbal medicine Gan-Cao
(licorice). J Chromatogr A 2009; 1216(11): 1954-1969.
47. Mike Lee S and Edward Kerns H: LC/MS applications in drug development. Milestone Development Services, Pennington, New Jersey, 24 July 1999.
48. Ip SP, Zhao M, Xian Y, Chen M, Zong
Y and Tjong YW: Quality assurance for Chinese herbal formulae: Standardization of IBS-20, a 20-herb preparation. J Chin Med
2010; 5:8-9
49. Shen AQ, Morgan L, Barroso ML and
Zhang X: Tandem Method development of LC-MS analysis of aminoglycoside drugs: Challenges and solutions. Answering Pharmaceutical Questions with Discipline and Ingenuity; 5(2):567-569. ; tandemlabs.com/documents/ ASMS08-
Angela-Web.pdf 2010
50. Matthew C and Henry R: Supercritical fluid chromatography, Pressurized liquid extraction, and supercritical fluid extraction.
Anal Chem 2006; 78: 3909.
51. Agrawal H, Kaul N, Paradkar AR and Mahadik KR: Standardization of crude extract of neem seed kernels (Azadirachta Indica A. Juss) and commercial neem based formulations using HPTLC and extended length packedcolumns SFC Method.
Chromatographia 2009; 62(3):183-195.
52. Ganzera M: Quality control of herbal medicines by capillary electrophoresis: Potential, requirements and applications.
Electrophoresis 2008; 29:3489-3503.
53. Wen HG, Lin SY, Jia L, Guo XK, Chen
XG and Hu ZD: Analysis of protoberberine alkaloids in several herbal drugs and related medicinal preparations by non-aqueous capillary electrophoresis J Sep Sci. 2005;
28(1): 92-97.
54. Sombra LL, Gomez MR, Olsina R, Martinez LD and Silva MF: Comparative study between capillary electrophoresis and high performance liquid chromatography in 'guarana' based phytopharmaceuticals. J
Pharm Biomed Anal. 2005; 36: 989-994.
55. Sun Y, Guo T, Sui Y and Li F: Fingerprint analysis of Flos Carthami by capillary electrophoresis. J Chromatogr B.
2003; 792: 147-152.
56. Wang LC, Cao YH., Xing XP and Ye
JN: Fingerprint Studies of Radix Scutellariae by Capillary Electrophoresis and High Performance Liquid chromatography. Chromatographia 2005;
62: 283-288.
57. Tistaert C, Dejaegher B and Heyden YV: Chromatographic separation techniques and data handling methods for herbal fingerprints: A review. Anal Chim Acta 2011; 690:148-161.
58. Silva Juinior JOC, Costa RMR, Teixeira FM and Barbosa WL: Processing and quality control of herbal drugs and their derivatives. J Herbal Medicine 2011;
14(1):115-114.
59. Yongyu Z, Shujun S, Jianye D, Wenyu W, Huijuan C and Jianbing W: Quality
control method for herbal medicine -Chemical fingerprint analysis. Chapter 10, pp 171-194. In: Quality control of herbal medicines and related areas, Shoyama Y (ed.), InTech, 2011.
60. Singh SK, Chaudhary A, Rai DK and Rai SK: Prepration and characterization of a mercury based Indian traditional drug -Ras sindoor. Int J Tradition Knowledge. 2009; 8(3): 346-351.
61. Di L, Zhang Y and Pan H: Study on the extraction of volatile oil in dry ginger and the preparation of its beta-cyclodextrin inclusion compound. J Chin Herbal Medicine. 2000; 23(2): 99-101.
62. Singh D, Rawat MSM, Semalty A and Semalty M: Emodin- phospholipid complex: A potential of herbal drug in the novel drug delivery system. J Therm Anal Calorim published online 03 July, 2011; DOI 10.1007/s10973-011-1759-3.
63. Semalty A, Semalty M, Singh D and Rawat MS: Preparation and characterization of phospholipid complexes of naringenin for effective drug delivery. J Inclusion
Phenomen Mac Chem. 2010; 67(3): 253¬260.64. Rai V, Kakkar P, Khatoon S, Rawat
AKS and Mehrotra S: Heavy metal accumulation in some herbal drugs. Pharmaceut Biol 2001; 39(5):384-387. Yuan X, Chapman RL, Wu Z. Analytical methods for heavy metals in herbal medicines.
Phytochem Anal 2011; 22:189-198.
65. Taijun H, Zhengxing Z, Shanshi D and Yu Z: The determination of trace levels of selenium contained in Chinese herbal drugs by differential pulse polarography. J Chinese
Herbal Med 1992; 39(10): 1277-1280.
66. Baranowska I, Srogi K, Wochowicz A, Szczepanik K .Determination of heavy metal contents in samples of medicinal herbs. J
Environ Studies. 2002; 11(5):467-471.
67. Bao XYX: Determination of total flavonoids in Epimedium brevicornum maxim by differential pulse polarography.
Phytochem Anal 2005; 24(8): 606-610.
68. Michelitsch A, Biza B, Wurglics M,
Schubert-Zsilavecz M, Baumeister, A and Likussar W: Determination of hypericin in herbal medicine products by differential pulse polarography. Phytochem Anal 2000;
11: 41-44.
69. Huang S and Chang WH: Advantages of nanotechnology based Chinese herb drugs
on biological activities. Curr Drug Metabol
2009; 10: 905-13.
70. Prabhu N, Divya Raj T, Gowri Yamuna K, Siddiqua Ayisha S and Joseph N: Synthesis of silver phyto nanoparticles and their antibacterial efficacy. J Nanomater Biostruct. 2010; 5(1):185 - 189.
71. Dong TP and Sung CH: Exuberence or bubble? Study of nanobased herbal medicines patients in the PR China. J Intell
Prop Rig 2011; 16:225-234.
72. Regulatory Issues for Traditional Medicine - Herbal Research. Dr Arun Bhatt MD (Med) FICP (Ind). Member Faculty of Pharmaceutical Medicine (Royal College UK) President Clinical Development. Chembiotek Research International Pvt. Ltd.
73. International Conference On Recent Advances in and Efficacy of Ayurvedic Formulation, Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, U.P,
INDIA.

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