Buradasınız

Anasayfa » Content

HORMON REPLASMAN TEDAVİSİNİN RENAL FONKSİYONLAR ÜZERİNE ETKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The effect of hormone replacement therapy on renal functions. To study the effects of HRT on kidney functions in postmenopausal women, renal functions have been studied in 55 patients. 15 Cases were take as control and the remaining 40 cases were included in thestudy group. In the study group transdermal 17-b -estradiol 50mgr/day have been used cyclically for three months. Didrogesteıon lOmg/day has been added to therapy for the last 2 \veeks of cyclic therapy. Glomerular function rate (GFR), clearence of urea and urinary volume (min) have been determined before and after treatment. GFR has been found to increase significantly from 114.9+0.4 ml/min to 134+0.4 ml/min and ciearance of urea from 72.2+0.5 to 84.0±0,4 ml. And lirine volume from 4.2±0.2ml to 11.2+0.01 ml. no changes has been seen in control group
Bookmark/Search this post with
Abstract (Original Language): 
Menopozda kullanılan hormon replasman (HRT) tedavisinin böbrek fonksiyonları üzerine olan etkilerini incelemek amacıyla 15' i kontrol, 40' ı da tedavi uygulanan grup olmak üzere toplam 55 hastada böbrek fonksiyonları incelenmiştir. Hastalara 3 ay boyunca, her ay transdermal 17-b-estradiol 50 mgr/gün ve 10 mg didrogstcron bir aylık östrojen tedavisinin son iki haftasına eklenmesi suretiyle HRT uygulanmıştır. Tedavi öncesi ve sonrası hastalarda GFR, üre klirensi ve idrar hacim/dak. ölçülmüştür. GFR' nin HRT ile anlamlı ortalama % 114.9±0.4 cm3/dak.'dan 134.O+0.4 cm3/dak.' ya, aynı şekilde üre klirensinin % 72.2+0.5 ml/dak.' dan 84.010.4 ml/dak.' ya çıktığı, idrar miktarının da (dak.' da) 4.2±0.2 ml'den 11.2+0.01 ml'ye çıktığı saptanmıştır. Kontrol grubunda ise bu değerlerde herhangi bir farklılık saptanmamıştır. Sonuç olarak HRT' nin renal Perfüzyonu arttırdığı bunun da GFR, üre klirensi ve idrar hacminde artmaya sebep olduğu saptanmıştır. HRT' nin böbrek fonksiyonlarını olumlu yönde etkilediği sonucuna varılmıştır.
FULL TEXT (PDF): 
PDF icon arastirmax-hormon-replasman-tedavisinin-renal-fonksiyonlar-uzerine-etkisi.pdf
  • 4
456-162
  • Turkish

REFERENCES

References: 

1. Clarkson T.A, Washburn S.A, Klein K.P.: Sex steroid and atherosclerosi.s in animal model. Safety aspects of HRT. Novo Nordisk proceedings (Wello medical limited), Copenhagen page 101,1992.
2. Colins Pand Beale C.M.:Cardioprotective role of HRT, a clinical update, parthenon publishing group, New York p.27, 1996.
3. Dagher F.J, Lyons J.H, Ball M.R, Moore F.D.;
• Hemorrhage in normal man: II.Effectsof mannitol on plasma volume and body water dynamics follv/ing acute blood loss. Ann. Surg. 163:505, 1966.
4. De Ziegler D, Benis R, Frydman R.: Vascular resistance of uterine arteries. Fertility and sterility 55:775-9, 1991.
5. Faik R.J, Jenette C.J.: Glomerular disease in the eldeıiyin nephrology, Ed.Jacobson H, Striker G, Klahrs, mosby.St Louis p:518, 1995.
6. Gangar K.F, Vyas S, Whitehead M.: PI in the internal carotid artery is influenced by transdermal estradiol and time since menopause. Lancet 338, 839-42, 1991.
7. Geer J.C, McGill H.C, Strong J.P.: The fine structure of human atherosclerotic lesions. Am J Pathol 38:263, 1963.
8. Gennari FJ, and Kassirer J.P: Osmotic diuresis, N.engle, J Med. 291:714, 1974.
9 Gilbert H.M, William J.C. and VVilliam O.B.: Electrolyte excretion and free water production during onset of acute diuresis. Am J.Physiol. 228:1304, (1975).
10. Hamburger J, Richer G, Crosnier J.: Nephrologie. Editions Medicales Flammarion, Paris, Tome: 1, 1966.
11. Han S.Z, Karahi H, Ouchi Y.: 17 Beta estradiol inhibitis calcium influx and calcium relase circulation 91, 2619, 1995.
12. Hollenberg N.K, Epstein M, Bash R.I, Merril J.P: "No man's land" of the renal vasculature. An arteriographic and hemodinamic assesment of the interlobar and arcuate arteries in essential and accelarated hypertension. Am J.Med. 47:845, 1969.
13. Jiang C, Wilson P.A, Sarrel P.M.: Effects of 17 beta estradiol on contraction calcium current and intracellular free calcium in cardiac myocytes.Br J. Pharmacol. 106. 739, 1992.
14. Lassiter W.E. Gotischalk C.W, Mylle M.: Microptıncuıu' study of net transtubular movement of watcr and urea ın non diuretic mammalian kidney. Anı.J. Physiol. 200:1139, 1961.
15. Lillien O.M.Jomes S.C. and Mueller C.B.: The mechanism of mannitol diuresis. Gynec. Obstet. 117:221, 1963.
16. Magnen R.R, and Rosenfeld C.D.: Local and systemic estradiol 17 beta on uterine and systemic vasodilation. Am.J. Physiol, 256:536, 1989.
17. Myers P.R, Guerra R.J, harrison O.G.: Relase of No and EDRF from cultured bovine aortic
HORMON REPLASMAN TEDAVİSİNİN RENAL
FONKSİYONLAR ÜZERİNE ETKİSİ
endothelial cells. am.J.Physiol. 256, H 1030 7, 1989.
18. Khuri R.N, Wiederholt M.Strieder N. and Giebish G.: effects of graded solute diuresis on renal tubular sodium transport in the rat. Am.J. Physiol. 228:1262, 1975.
19. Kobrin S, Madaio M.P.:Renal biopsy in nephrology. Ed Jacobson H. Striker G. Klar S. Mosby St. Louis P:65, 1995.
20. Palmer R.M, Ferrige A.G.: Nitric oxyde relase accounts for biological activity of endothelial derived relaxing factor nature. (London) 327:524¬6, 1987.
21. Pines A, Fisman E, Levo Y.: The effects of HRT in normal postmenopousal vvomenş: measurements of Doppler derived parameters of aortic flow. Am. J. Obs. Gynecol 164:806-12, 1991.
22. Polderman K.H, Stehonwer C.D, Van Kamp G.J.: Influence of sex hormones on plasma endothelin levels. Ann. Intern Med, 118:429, 1993.
23. Seely J.F, Dirks J.H.: Micropuncture study of hypertonic mannitol diuresisin the proximal and distal tubule of the dog kidney.J.Clin. Invest. 48:2330, 1969.
24. Stice S.L, Ford S.P, Rosazzo: Role of 4 hydroxyladted estradiol in reducing calcium uptake of uterine smooth muscle cells through potential sensitive channels. Biol. Reprod. 36, 361¬8, 1987.
25. Stice S.L, Ford S.P,Rozassa: Interaction of 4 hydroxylated estradiol and potential sensitive calcium channels in altering uterine blood flow.Biol. Reprod. 36,369-75, 1987.
26. Steinberg D, Parthasarathy S, Carew T.E.:Beyond chlosterol.N. England J.Med. 320, 915, 1989.
27. Svarstad E, iversen B.M, Ofstad J.: Extended measurement of glomerular filtration rate and effective renal plasma flow in ambulatory patients. Scand. J.Urol.Nephrol. 29(4):375, 1995.
28. Stochendfeld N.S, Gleim G.W, Zabetakis P.M, Nicholas J.A.: Fluid balance and renal response follovving dehydrating exercise in well-trained men and women.Eur.J. Physiol. 72 (5-6); 468-77,1996.
29. Zappe DH, Bell G.W, Swartzentruber H,Wideman R.F, Kenney W.L.: Age and regulation of fluid and electrolyte balance during repeated exercise session. Am.J. Physiol. 270 (1 pt2); p:71-9, 1996.

Thank you for copying data from http://www.arastirmax.com