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OKSİDATİF STRES GÖSTERGESİ OLARAK SERUMDA TOTAL SÜLFİDRİL DÜZEYLERİ VE GLUTATYON PEROKSİDAZ AKTİVİTESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

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Abstract (2. Language): 
Total thiol levels and glutathione pcroxidase activity as parameters of axidative stress. Free radicals play an important role in the pathogenesis of severai diseases. We invcstigated prooxi-dant-antioxidant balance İn serum of oid men and of patients with coronary artery diseases, coloreetal and prostat cancer. For fhis reason, malondialdehyde (MDA), antioxidant activity (AOA), total thiol groups and glutathione peroxidasc (GSH-Px) activity were measurcd in serum. Although serum MDA levels and AOA did not change, total thiol groups and GSH-Px activity were found to decrease in ali patients. These results m ay indicate that the determinati-on of total thiol groups and GSH- Px activity may be used as markers to investigate prooxi-dant-antioxidant balance in serum.
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Abstract (Original Language): 
Serbest radikaller birçok hastalığın etyopatojenezinde etkin bir rol oynamaktadır. Çalışmamızda yaşlı kişilerde, koroner arter hastalarında, kolon ve prostat kanserli hastalarda prooksidan-antioksidan denge incelendi. Bu amaçla serumda malondİaldehit (MDA) düzeyleri, antioksi-dan aktivite (AOA), total sülfidrİI içeriği (t-SH) ve glutatyon peroksidaz aktivitesi (GSH-Px) ölçüldü. Serum MDA ve AOA incelediğimiz hasta gruplarında değinmemekle birlikte, tüm gruplarda serum GSH-Px aktivitesi ve t-SH içeriğinde anlamlı bir azalma saptandı. Sonuçlarımıza göre, serumda GSH-Px aktivitesi ve t-SH içeriğini belirlemenin prooksidan-antioksidan dengeyi incelemede yararlı bir gösterge olabileceği ileri sürülebilir
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  • 3
264-267
  • Turkish

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