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T HÜCRE KLONALITESI GÖSTEREN PRIMER SAF ERİTROSİT APLAZİLİ İKİ OLGU: İMMUNSUPRESSİF TEDAVİ YANITI

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Clonality of acquired primary pure red celi aplasia in two cases: Effectiveness of immuno-suppressive treatment. Primary pure red celi aplasia (PRCA) was diagnosed in two male pati-ents, 65 and 69 years old respeetively. In both, surface markers of pcripheral blood nuclear cells revealed the presence of TCR afi+ phenotype. Clonality of T cells was confİrmed by the polymerase chain reaction in both patients, in whom, prednisone at a dose of 1 mg/kg/day cor-reeted the anemia and lower doses caused its renev/al, whereas horse antithymocyte globulin (ATG) (20 mg/kg/day 1 to 8 +) seems to have treated it as if permanently (second case) since hemoglobin values are about 15 g/dl at the time of writing. We, therefore, suggest that, patientş. w_ith_acquired primary PRCA should be sereened to detect the presence of a T-cell döne and recommend that, treatment should start earlier with ATG, if PRCA is due to a T-cell clonal dİsorder.
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Abstract (Original Language): 
Primer saf eritrosit aplazİsİ (SEA) 65 ve 69 yaşlarında İki erkek hastada teşhis edildi. Her iki olguda çevre kanı mononükleer hücrelerinin yüzey marktr incelemeleriyle T hücre reseptörünün (TCR) ccji+ fenotiphıde olduğu saptandı. PCR ile T hücre klonaütesi gösterildi. Her iki olguda aneminin 1 nıg/kg/gün prednisoîon ile düzeldiği, İlaç dozu azaltılınca tekrarladığı, at kaynaklı antitimoMt globulinle (ATG) (20 mg/kg/gün, 8 gün süreyle) tekrar düzeldiği ve ikinci olguda makalenin yazıldığı tarihte hemoglobinin 15 g/dl'yi bulduğu tesbit edildi. Bu iki olgu_nçdçniyle..edinsel primer SEA'Hlerde T hücre klonalitesinin aranmasının ve klonâ-litcrgosterenlerin tedavisinde ÂTG'ye öncelik verilmesinin uygun olacağı kanısına varıldı.
FULL TEXT (PDF): 
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  • 4
444-448
  • Turkish

REFERENCES

References: 

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