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MYELODİSPLASTİK SENDROMDA SERUM BETA 2-MİKROGLOBULİN DÜZEYLERİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Serum beta 2- microglobulin levels in myelodisplastic syndrome. Elevated serum P2-microg-lobuin (P2-m) levels are associated with poor prognosis in several lymphoproliferative and myeloproliferative disorders. Twenty three patients with myelodisplastic syndrome (MDS) had P2-m estimated at presentation. A significant association was found betvveen P2-m and MDS, although the difference betvveen the MDS FAB subtypes was not statistically significant. These raised serum levels are probably derived from increased celi turnover and/or inef-fective eritro/myelopoiesis. Monitoring serum P2-m levels may provide significant diagnostic, not prognostic, information. Its prognostic importance in MDS requires investigation in much more cases of MDS subtypes
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Abstract (Original Language): 
Lenfoproliferatif ve myeloproliferative hastalıklarda serum (32-m (beta 2-mikroglobulin) düzeylerindeki yükseklik kötü prognozla birlikte görülmektedir. Bu çalışmada MDS li (myelo-displastik sendromlu) yirmi üç hastada (32-m düzeylerine bakıldı. Serum (32-m düzeyleri ile MDS arasında anlamlı ilişki bulunurken, MDS nin alt tipleri arasında istatistiksel olarak anlamlılık yoktu. MDS de yükselmiş olan serum |32-m düzeylerinin hücre turnoverındaki artış-dan ve/veya inefektif eritro/myelopoezden kaynaklanması olasıdır. (32-m düzeylerinin MDS nin prognostik olarak değerlendirilmesinde değil, fakat tanıda yardımcı olabileceği söylenebilir. Prognostik önemi için daha fazla sayıda MDS alt gruplarının yer alacağı çalışmalara gerek vardır.
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  • 1-2
66-73
  • Turkish

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