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ODONTOJENIK KİSTLERDE CEA (KARSİNOEMBRYONİK ANTİJEN) VE EMA (EPİTELYAL MEMBRAN ANTİJEN) İMMUNO-REAKTİVİTESİ

CEA (CARCINOEMBRYONIC ANTIGEN) AND EMA (EPITHELIAL MEMBRANE ANTIGEN) IMMUNO-REACTIVITIES IN ODONTOGENIC CYSTS

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1994

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this research, the patients who were referred to Dental Faculty of Istanbul University, Department of Oral Surgery were evaluated and 30 cases who were diagnosed as keratocyst, radicular and follicular cysts having investigated according to the presence of carcinoembryonic antigen (CEA) and epithelial emmbrane antigen (EMA). The histopathological diagnosis of the cysts have been carried out at the Institute of Oncology of Istanbul University while the immunohistochemical examinations were done at the Pathology Department of Cerrahpaşa Medical Faculty of Istanbul University. The sections ofSfAm. thickness were subjected to both the CEA and EMA by the method of peroxidase-antiperoxidase (PAP). The CEA immunoreac-tivity was observed in all the keratocysts (%100), and in follicular (%60) and radicular (%20) cysts, respectively. Based on the results, we would like to emphasise that the CEA has a chracteristic of being a spesific marker in the determination of aggressive property of odotogenic cysts.
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Abstract (Original Language): 
Bu çalışmada, İ.Ü. Diş Hek. Fak. Ağız Diş Çene Hast. ve Cerrahisi Anabilim Dalı'na başvuran ve yapılan klinik, radyolojik ve patolojik tetkikleri sonucu keratokist, radiküler kist ve foliküler kist tanısı konan, toplam 30 vak'a immuno-histokimyasal yöntemle çalışarak, karsinoembriyonİk antijen (CEA) ve epitelyal membran antijen (EMA) varlığı açılarından değerlendirildi. Enükle edilen kistlerin histo-patolojik teşhisi İ.Ü. Onkoloji Enstitüsü'nde, immunohis-tokimyasal yöntemle değerlendirilmeleri ise İ.Ü. Cerrahpaşa Tıp Fak. Patoloji Anabilim Dalı'nda yapıldı 5[im kalınlığında hazırlanan kesitlere peroksidaz-antiperoksidaz (PAP) yöntemiyle hem CEA hem de EMA uygulandı. Ke-ratokistlerin tümünde (%100) olmak üzere, sırasıyla foliküler kistler (%60) ve radiküler kistlerde (%20) CEA im-munoreaktivitesi gözlendi. Bu sonuçlara dayanarak, CEA'in kistlerin aggresivliğinin belirlenmesinde, odonto-jenik kistlerde spesifik bir marker olma özelliğine sahip olduğunu vurgulamak istiyoruz.
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  • 4
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  • Turkish

REFERENCES

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