Buradasınız

Anasayfa » Content

FARKLI ENDODONTIK YIKAMA SOLÜSYONLARININ TOKSİK VE NEKROTİK DOKU ÇÖZÜCÜ ETKİLERİNİN KARŞILAŞTIRMALI OLARAK İNCELENMESİ

COMPARATIVE INVESTIGATION OF THE TOXIC AND NECROTIC TISSUE-DISSOLVING EFFECTS OF DIFFERENT ENDODONTIC IRRIGANTS

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The purpose of this study was to compare the necrotic tissue-dissolving and toxic effects of Cetrexidin and chlorhexidine gluconate with those of two different dilutions (5.25% and 0.5%) of sodium hypochlorite (NaOCI). 5.25% NaOCI and sterile saline were used as positive and negative controls, respectively. In the first part of the study, 0.1 ml of each test solution was injected subcutaneously into predetermined areas on the rabbit dorsum. Test areas were histologically examined 2 hours, 48 hours and 2 weeks after the injections. In the second part, dissolving effect of the inrigants was studied on the necrotic bovine muscular tissue. The results of this study showed that all test solutions exhibited mild inflamation at 2 hours. While 5.25% NaOCI caused the severe inflamatory tissue reactions at 48 hours and 2 weeks, other solutions exhibited moderate inflamation at 48 hours; after 2 weeks, the severity of inflamation was decreased to the mild rate. The fibrosis was observed in all experimental groups except for negative control. 5.25% NaOCI was significantly more effective than 0.5 % NaOCI as a necrotic tissue solvent Necrotic tissue-dissolving effect of Cetrexidin and chlorhexidine gluconate was less effective than 0.5% NaOCI.
Bookmark/Search this post with
Abstract (Original Language): 
Bu çalışmanın amacı Cetrexidin ve klorheksidin gluko-nat'ı, toksik ve nekrotik doku çözücü etkileri bakımından iki farklı konsantrasyondaki (% 5.25 ve %0.5) sodyum hipoklorit (NaOCI) ile karşılaşürmah olarak incelemektir. Çalışmada %5.25'lik NaOCI pozitif kontrol, serum fizyolojik ise negatif kontrol olarak kullanılmıştır. Çalışmanın birinci bölümünde herbir yıkama solüsyonunun 0.1 ml'si tavşanın sırt bölgesinde daha önce belirlenen bölgelere cilt altı bağ dokusuna enjekte edildi. Enjeksiyon bölgeleri 2 saat, 48 saat ve 2 hafta sonra histopatolojik olarak incelendi ve oluşan doku reaksiyonları değerlendirildi. İkinci bölümde yıkama solüsyonlarının nekrotik sığır kas dokusu üzerindeki çözücü etkileri incelendi. Çalışma sonunda; iki saatlik periyotta tüm solüsyonların hafif yangı oluşturduğu gözlendi. %5.25'lik NaOCI 48 saat ve 2 haftada şiddetli yangısal doku reaksiyonlarına sebeb olurken; diğer test solüsyonlarının 48 saatte orta şiddette yangı oluşturduğu; 2 hafta sonra oluşan yangının en az düzeye gerilediği saptandı, iki haftalık periyotta negatif kontrol dışında tüm deney gruplarında fibrozis gözlendi, %5.25'lik NaOCI'in, %0.5iik NaOCI'e oranla daha etkili bir nekrotik doku çözücü olduğu, Cetrexidin ve klorheksidin glukonaün nekrotik doku çözücü etkisinin %0.5'lik NaOCI'den bile düşük olduğu saptandı.
FULL TEXT (PDF): 
PDF icon arastirmax-farkli-endodontik-yikama-solusyonlarinin-toksik-nekrotik-doku-cozucu-etkilerinin-karsilastirmali-olarak-incelenmesi.pdf
  • 2
87
94
  • Turkish

REFERENCES

References: 

1. Becker GL, Cohen S, Borer R. The sequelae of accidentally injeting sodium hypochlorite beyond the root apex. Report of a case. Oral Surg 1974;38:633-8.
2. Becking AG. Complications in the use of sodium hypochlorite during endodontic treatment: report of three cases. Oral Surg 1991;71:346-8.
3. Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease. Chapter 3: Inflamation and repair. 5 th edn. Philadephia: WB Saunders Co, 1996;51-92.
4. Ehrich GD, Brian D, Walker WA. Sodium hypochlorite accident: inadverfent injection into the maxillary sinus./ Endodon 1993;19:180-2.
5. Giulietti MP, Rotondo E. Cetrexidin: un valido ausilio per la terapia endodontica sul paziente poco o non collaborate. Estratto da Odontostomatologia 1996;6:1-4.
6. Grossman LI, Meiman BW. Solution of pulp tissue by chemical agent. JADA 1941;28:223-5.
7. Hand RE, Smith ML, Harrison W. Analysis of the of dilution on the necrotic tissue dissolution property of sodium hypochlorite./fiuiotioM 1978;4:60-4.
8. Harrison JW, Hand RE. The effect of dilution and organic matter on the antibacterial property of 5.25% sodium hypochlorite.,/ Endodon 1981;7:128-32.
9. Harrison JW. Irrigation of the root canal system. Dent Om North Am 1984;28:797-808.
10. Harry F. Endodontics in clinical practice. London: Wright, 1990;140-3.
31. Herrmann JW, Heicht RC,Jackson F, Complications in therapeutic use of sodium hypochlorite. J Endodon 1979;5:160.
12. Ingle JI, MullaneyTA, Grandich RA, TaintorJF, Fa-hid A. Endodontic cavity preparation. In: Ingle JI, TaintorJF, Eds. Endodontics. 3 rd. edn. Philadelphia: Lea&Febiger, 1985:178-85.
13. Ingram TA. Response of the human eye to accidental exposure to sodium hypochlorite. J Endodon 1990;16:235-8.
14. Klimm W- Krause L, Krause P, Wenzel J. Toxicity of different endodontic antiseptics. Stomatol DDR1989;$9:153-5.
15. Lamers AC, Van Mullem PJ, Simon M. Tissue reactions to sodium hypochlorite and iodine potassium iodide un-
ver clinical conditions in monkey teeth. J Endodon
1980;6:788-92.
16. Loe H, Rindom Schiott C. The effect of mouth rinses and topical application of chlorhexidine on the development of dental plaque and gingicitis in man. /Periodont Res 1970;5:79-83.
17. Moorer WR, Wesselink PR. Factor promoting the tissue dissolving capability of sodium hypochlorite, ftıfc EndodJ 1982;15:187-96.
18. Morgan RW, Carnes DL, Montgomery S. The solvent effects of calcium hydroxide irrigating solution on bovine pulp tissue./EndWon 1991;17:165-8.
19. Osetek Em. Endodontic medicaments and irrigating solutions. In: Holroyd SV, Wynn RL, Reque-Clark B, eds. Clinical pharmacolgy İn dental practice, 4 th edn. St Louis: CF Mosby Co, 1988:505-19.
20. Pashley El, Birdsong NL, Bowman K, Pashley DH. Cytotoxic effects of NaOCI on vital tissue. J Endodon 1985;11:525-28.
21. Reeh Es, Messer HH, Long-term paresthesia followi-ung inadvertent forcing of sodium hypochorite through perforation in maxillary incisor. Endod Dent Traumatol 1989;5:200-3.
22. Sabala Gl, Powell SE. Sodium hypochlorite injection into periapical tissues. J Endodon 1989;15:490-2.
23. Salzgeber RM, Brilliant JD. An in vivo evaluation of the penetration of an irrigating solution in root canals.yi&i-dodon 1977;3:394-9.
24. Southard SR, Drİsko CL, Killoy WJ, Cobb CM, Tria DE. The effect of 2.0% chlorhexidine digluconate irrigation on clinical parameters and the level of Bacteroides gingivalis in preiodontal pockets. J Periodontal 1989;60:302-9.
25. Spangber L, Engstörm B, Langeland K. Biologic efect of dental materials. 3. Toxicity and antimicrobial eHect of endodontic antiseptics in vitro. Oral Surg 1973;36:856-71.
26. Spangberg L, Safavi KE; Kaufman A, Pascon EA. Anti-bicrobial and toxic effect in vitro of a Bisdequalinium acetate solution for endodontic use. Endodon 1988;14:175-8.
27. The SD. The solvent action of sodium hypochlorite on fixed and unfixed necrotic tissue. Oral Surg 1979;47:558¬61.
94
Türkün M Gökay N Özdemİr N
28. The SD, Maltha JC, Plasschaert AJM. Reactions of guinea pig subcutaneous connective tissue following exposure to sodium hypochlarite. Oral Surg 1980;49:460-5.
29. Türk Standartları TS 3464/Temmuz 1980: Sodyum hipoklorit deney metodlan, Ankara: İkbal Matbaası, 1980:1¬2.
30. Türkün M, Cengiz T. The effects of sodium hypochlorite and calcium hydroxide on tissue dissolution and root canal cleanliness. Ini Endod/1997;30:33S42.
31.
Türkün M, Eltem R, Ateş M. Farklı irrigasyon solüsyonlarının antibakteriyal etkilerinin karşılaştırmalı olarak
incelenmesi. İÜ Diş Hek Der'de yayınlanmak üzere kabul edildi.
32. Wayman BE, Kopp WM, Pinero GJ, Lazari EP. Citric and lactic acids as root canal irrigants in vitro. J Endodon 1979;5:258-65.
33. Wennberg A. Biological evaluation of root canal antiseptics using in vitro and in vivo methods. Scand J Dent Res 1980;88:46-52.
34. Yeşilsoy C, Whitaker E, Cleveland D, Philips E, Trope M. Antimicrobial and toxic effects of established and potential root canal irrigant. J Endodon 1995;21:513-5.

Thank you for copying data from http://www.arastirmax.com