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NORAL KREST KÖKENLİ HÜCRELERİN AĞIZ VE ÇENE-YUZ OLUŞUMUNA KATKILARI VE NEDEN OLDUKLARI ANOMALİLER

CONTRIBUTIONS OF NEURAL CREST-DERIVED CELLS TO THE DEVELOPMENT OF ORAL AND MAXILLOFACIAL REGION AND THE ANOMALIES CAUSED BY THESE CELLS

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Neural crest cells are derived from the neuroectodermal cells which occur in course of the separation of surface ectoderm and neural tube during the embryogenesis. These cells have ability to develop many different cells and tissues in the human and have also ability to differentiate. Neural crest cells are important for dentistry because of oral and maxillofacial tissues including teeth are formed by migration and differentiation of these cells. During development, any malformation either migration or differentiation of these cells cause craniofacial anomalies. In this study, formation of the neural crest cells, formation of structures which derived from neural crest cells and the anomalies that is caused by neural crest cells which participate in formation of head, neck, face and oral cavity region were explained. It is learned that healthy formation, differantiation and migration of neural crest cells are necessary for development of structure in the oral and maxillofacial region.
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Abstract (Original Language): 
Nöral krest hücreleri embriyonal dönemde nöral tüpün yüzey ektoderminden ayrışması sürecinde oluşan nöroektodermal hücrelerdir. Bu hücreler insanda çok değişik hücre ve doku tiplerini oluşturabilme kapasitesine ve farklılaşma yeteneğine sahiptirler. Ağız, çene-yüz ve diş dokularının, nöral krest kökenli hücrelerin göç edip farklılaşmalarının katkısı ile oluşması nedeniyle bu hücreler diş hekimliği araştırmaları açısından önemlidir. Gelişim sırasında bu hücrelerin göçünde ya da farklılaşmasındaki herhangi bir bozukluk ağız ve çene-yüz bölgesinde çeşitli anomalilere neden olur. Bu çalışmada, nöral krest hücrelerinin oluşumu, bu hücrelerden köken alan oluşumlar ve baş, boyun, yüz ve ağız boşluğu oluşumuna katılan nöral krest kökenli hücrelerden kaynaklanan anomaliler anlatılmıştır. Ağız ve çene-yüz bölgesindeki birçok yapının oluşumu ve normal gelişmesi için nöral krest hücrelerinin sağlıklı bir şekilde oluşması, göç etmesi ve farklılaşmasının gerektiği anlaşılmaktadır
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