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E S ANSİ YEL HİPERTANSİYONLU HASTALARDA TÜKÜRÜK SODYUM VE POTASYUM DEĞERLERİNDE MEYDANA GELEN DEĞİŞİKLİKLER

CHANGES IN THE LEVELS OF SALIVARY SODIUM AND POTASSIUM IN PATIENTS WITH ESSENTIAL HYPERTENSION

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
It has been known that the metabolism of some elements in the body is affected by essential hypertension. However the interaction between essential hypertension and electrolytes in blood and urine samples has been investigated in several studies, this interaction in saliva still requires further studies. The aim of this study is to examine the changes in concentration of some trace elements like sodium, potassium of saliva in patients who have essential hypertension. It is also aimed to search if laboratory findings associated with salivary elements have diagnostic importance. 20 patients with essential hypertension, 20 patients undergoing antihypertensive treatment for 10 years and 20 normotensive patients were included in this study. Mixed saliva secretion samples from all patients were collected for determining concentrations of sodium and potassium. In addition to conventional laboratory techniques, neutron activation analysis and multi-element discriminating techniques were used. As a result sodium levels in patients with hypertension, undergoing antihypertensive treatment and in normotensive patients were found higher than the levels in patients with hypertension who do not undergo any treatment. Potassium level in first two group patients was found statistically less than the last group.
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Abstract (Original Language): 
Esansiyel hipertansiyonun vücutta elektrolit dengelerini etkilediği bilinmektedir. Hipertansiyon ve elektrolit ilişkisinin tükürükte incelenmesi, tükürüğün tanı amaçlı kullanımının değerlendirilmesi açısından önem taşımaktadır. Bu çalışmanın amacı, esansiyel hipertansiyonlu hastaların tükürüğündeki sodyum (Na), potasyum F(K) miktarlanndaki sapmaları inceleyerek, diagnostik açıdan laboratuar bulgularının önemini araştırmaktır. Çalışmaya esansiyel hipertansiyon teşhisi konulmuş 20, 10 yıldır antihipertansif ilaç tedavisi gören 20 ve normotansif 20 olmak üzere toplam 60 birey dahil edilmiştir. Her gruptaki bireylerin mikst tükürük salgıları alınarak sodyum, potasyum konsantrasyonları ölçülmüştür. Çalışmada esansiyel hipertansiyonlu hastalarda geleneksel laboratuar teknikleri, kan ve serum ölçümleri yanında tükürük salgısı ve tükürük elementleri incelenerek, nötron aktivasyon analiz tekniği ile multi-element ayırma tekniği kullanılmıştır. Sonuç olarak esansiyel hipertansiyon nedeniyle antihipertansif ilaç kullanan hastalarda ve normotansif bireylerde sodyum değerleri, henüz ilaç kullanmaya başlamamış esansiyel hipertansiyonlu hastalara göre istatistiksel olarak anlamlı derecede yüksek, potasyum değerleri ise anlamlı derecede düşük olarak saptanmıştır.
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