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Antibiyotik Dirençli Enterobacteriaceae’lerin Hayvan ve İnsan Sindirim Sistemi Arasında in vivo Plazmit Transferinden Kaynaklı Geçişi

Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer

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Abstract (2. Language): 
Recently, the main point of discussion is being undertaken whether the resistance of bacteria and plasmids could have been transmitted to humans from animals. Using antimicrobials in livestock production was previously shown to be followed by the occurrence of the resistant bacteria in the treated animals as well as in humans (caretakers, their family members etc.). Evidences exist that the transmission of resistance might have taken place from animals to humans. Many of these evidences were not direct and were based on the similarities between the resistance profiles of bacteria (among others indicatory E. coli) isolated from animals (poultry, pigs, cattle) and from humans having contact with these animals (farm workers, animal caretakers, their family members). Direct evidences have been based on the molecular methods allowing the detection of either clonally related, resistant zoonotic bacteria in humans and animals or related to resistance of plasmids isolated from humans and animals.
Abstract (Original Language): 
Esas tartışma konusu olan nokta, bakteri ve plazmit kaynaklı bakteri direncinin hayvanlardan insanlara nasıl geçebileceğidir. Antibiyotiklerin çiftlik hayvanlarında kullanımı daha önceleri dirençli bakterilerin tedavi görmüş hayvanlarda ve insanlarda varlığını göstermiştir (hayvan bakıcıları ve çiftlik çalışanları). Direncin geçişinin hayvanlardan insanlara doğru olabileceği şeklinde kanıtlar bulunmaktadır. Bu kanıtların çoğu, direkt olmamakla birlikte hayvanlardan (çiftlik hayvanları) ve bunlarla temas halindeki insanlardan (hayvan bakıcıları ve çiftlik çalışanları) izole edilen bakteriler arasındaki direnç profillerinin benzerliklerine dayanmaktadır. Direkt kanıtlar, birbirleriyle klonal ilişkili insan ve hayvan kaynaklı dirençli zoonotik bakterilerin veya yine bunlardaki dirençle ilgili plazmitlerin moleküler metotlara dayalı olarak saptanması ile olmuştur.

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