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DOĞAL İZOLATLARDA İMİPENEM (TİENAM) DİRENÇLİLİĞİ VE DAĞILIMI

RESISTANCE TO IMIPENEM (TIENAM) ANDDISTRIBUTION OF NATURAL ISOLATES

Journal Name:

  • Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi

Publication Year:

  • 2000
Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this study in which the imipenem resistance in natural isolates was searched, totally 1279 bacteria were studied and among the isolates 168 of tem (13.13%) were found to have imipenem resistance. The distribution of resistance in species are 22.98% in Pseudomonas sp., 16.6% in Acinetobacter sp., 2.21% in Klebsiella sp., 1.15 % in E.coli and 2.83% coliforms (Unidentified) respectively. Among the sewage isolates; the highest resistance was found to be in Acinetobacter sp., (100%) and no resistance in Enterobacter sp., was detected. The highest β-lactamase production was detected in Pseudomonas sp., (100%) isolated from soil and lowest was found to be E.coli (4.6%) isolated from sewage.
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Abstract (Original Language): 
Doğal izolatlarda imipenem (Tienam) dirençliliğinin araştırıldığı bu çalışmada toplam 1279 bakteri ile çalışılmış ve izolatlardan 168’inin (%13.13) imipeneme dirençli oldukları belirlenmiştir. Dirençliliğin cinslere göre dağılımı ise Pseudomonas sp.,’de %22.98, Acinetobacter sp.,’de %16.6, Klebsiella sp.,’de %2.21, Escherichia coli’de (E.coli) %1.15 ve koliformlarda (tiplendirilemeyen) %2.83 şeklindedir. Kanalizasyon izolatlarında en yüksek sıklıkta dirençlilik Acinetobacter sp.,de (%100) gözlenirken Enterobacter sp.,de dirençlilik saptanamamıştır (%100 hassas). Toprak izolatlarında sadece Pseudomonas sp.,de dirençlilik (%9.55) saptanmış diğer izolatlarda ise (Acinetobacter sp., Klebsiella sp., ve Proteus mirabilis) dirençlilik saptanamamıştır. İzolatlar arasında β-laktamaz üretimi en yüksek düzeyde topraktan izole edilen Pseudomonas sp.,de (%100) saptanırken en düşük oran kanalizasyondan izole edilen E.coli’de (%4.6) bulunmuştur.
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REFERENCES

References: 

1. SHIMADA, J. AND KAWAHARA, Y., 1994. Overviev of a new carbapenem,
panipenem/betamipron. Drugs. Exp. Clin. Res. 20 (6):241-5.
2. ÜNAL, S., 1994. Klinik Uygulamada Antibiyotikler ve Diğer Mikrobiyal İlaçlar.
Akalın, H.E., I. Baskı, Güneş Kitabevi Ltd. Şti. ANKARA. 132-43.
3. JONER, R.N., AND MARSHALL, S.A., 1994. Antimicrobial activity of cefepime
tested against Bush group I beta-lactamase-producing strains resistant to
ceftazidime.A Multilaboratory National and International Clinical Isolate Study.
Diagn. Microbiol. Infect. Dis. 19(1):33-38.
4. NGUYEN, V.J.C. AND GUTMANN,L., 1994. Resistance to antibiotics caused by
decrease of the permiability in gram-negative bacteria. Press. Med.
19:23(11):522, 527-31.
5. GOSPODAREK,M., 1993. Susceptibility to antibiotics and biochemical activity of
strains of Acinetobacter sp., isolated from various sources. Med. Dosw.
Microbiol. 45 (3): 331-7.
6. KUCZKOWSKA, J. AND DOLNA,I., 1992. Sensitivity of multiresistant bacterial
strains to imipenem (Tienam). Przeg.Lek. 49(5):151-3.
7. LEE, E.H., NİCOLAS, M.H., KİTZİS, M.D., PİALOUX, G., COLLATZ, E. AND
GUTMANN, L., 1991. Association of two resistance mechanisms in a clinical
isolate of Enterobacter cloacae with high-level resistance to imipenem.
Antimicrob. Agents and Chemother. 35(6):1093-98.
8. RAİMONDİ,A., TRAVERSO,A. AND NİKAİDO,H., 1991. Imipenem- and
Meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack
porins. Antimicrob. Agents and Chemother. 35(6):1174-80.
9. QUİNN, J.P., DARZİNS, A., MİYASHİRO, D., RİPP, S. AND MİLLER, R.V.,
1991. Imipenem resistance in Pseudomonas aeruginosa PAO:Mapping of the
OprD2 gene. Antimicrob. Agents and Chemother. 35(4): 753-5.
10. ARAKAWA, Y., MURAKAMİ, M., SUZİKİ, K., ITO, H., WAKHAROTAYANKUN,
R., OHSUKA, S., KATO, N. AND OHTA, M., 1995. A nowel integronlike
element carrying the metallo-beta-lactamase gene blaIMP. Antimicrob.
Agents and Chemother. 39(7):1612-5.
11.BLAHOVA,J., HUBKOVA, M. AND KRCMERY, V.SR., 1994 Phage F-116
transduction of antibiotic resistance from a clinical isolate of Pseodumonas
aeruginosa. J. Chemother. 6(3):184-8..
12.ANONYMOUS., 1978. Microbiologischen Handbuch, E. Merck, Darmstadt.
13.ÇOLAK, Ö. VE ARIKAN,B., 1990. Laktoz pozitif Enterobacteriaceae üyelerinin
teşhisi için geliştirilmiş yeni bir selektif agar besiyeri. KÜKEM Dergisi, 13
(12):15-21.
14.KİLBEY,B.J., LEGATOR,M., NİCOLAS,W., AND RAMEL,C., 1984. Handbook of
Mutagenicty Test Procedures. Second Edition., Amsterdam. Page 15-21.
15.ELMER, W.K., ALLEN, S.D., DOWEL, V.R. JR., JANDA, W.M., SOMMERS,
H.M. AND WİNN, W.L., 1988. Colar Atlas and Textbook of Diagnostic
Microbiology . Third Edition.
16.GİAMARELLUS, B.E.J., GRECKA,P. AND GİAMARELLOU,H.,
1995.Comparative in vitro killing activity of meropenem versus imipenem
against multiresistant nosocomial Pseudomonas aeruginosa. J. Chemother.
7(3):179-83.
17.BERGOGNE, B.E., 1995. The increasing significance of outbreaks of Acinetobacter
spp. : The need for control and new agents. J. Hosp. Infect. 30 suppl:441-52.
18.IAKOVLEV, V.P., BLATUN, L.A., KHLEBNİKOV, E.P., SAMYKİNA, T.D.
AND ELAGİNA, L.V., 1995. Use of imipenem in treatment of patients with
surgical infection. Antibioth. Chemother. 40 (4):40-4.
19.FASS, R.J., BARNİSHAN, J. AND AYERS, L.W., 1995. Emergence of bacterial
resistance to imipenem and Ciprofloxacin in a university hospital. J. Antimicrob.
Chemother. 36 (2): 343-353.
20.RAMADAN, M.A., TAWFİK, A.F. AND SHİBL, A.M., 1995. Effect of betalactamase
expression on susceptibility of local isolates of Enterobacter cloacae,
Serratia marcescens and Pseudomonas aeruginosa to beta-lactam antibiotics.
Chemotheraphy. 41 (3):193-9.
21.GÜR,D., 1994. Antibiyotiklere Direnç Gelişmesi; Klınik Uygulamada Antibiyotikler
ve Diğer Antimikrobiyal İlaçlar., Akalın,H.E., 1. Baskı, Güneş Kitabevi Ltd.Şti.,
Ankara, 19-37.

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