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Midenin Kötü Differansiye Medüller Karsinomu: Olgu Sunumu

Poorly Differenciated Medullary Carcinoma of the Stomach; Case Report

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Abstract (2. Language): 
Medullary carcinoma of the stomach is a rare tumor with an appearance similar to a poorly differentiated carcinoma but its behavior is similar to well differenti-ated gastric carcinoma. Our case is 82 years old male patient. Endoscopic biopsy was reported as an intes-tinal type adenocarcinoma. In the subtotal gastrec-tomy specimen at the posterior wall of the antrum and small curvature localizations an ulceroinfiltrative tumor with 6.5 cm diameter in size was found. His-topathological examinations showed that the tumor composed of thicker trabecular structure. The tumor cells were monomorphic with atypical appearance having bigger lymphocytes, indistinct cytoplasm and partially distinct nucleolus. Case was presented be-cause of medullary carcinoma of the stomach is a rare tumor and endoscopic biopsies constitute diag-nostic difficulty.
Abstract (Original Language): 
Midenin medüller karsinomu morfolojik açıdan kötü farklılaşma gösteren mide karsinomları arasında in¬celenmesine karşın biyolojik davranışı midenin iyi farklılaşma gösteren karsinomlarına benzeyen nadir görülen bir tümördür. Olgumuz 82 yaşında erkek hastadır. Endoskopik bi¬yopsisi intestinal tip adenokarsinom tanısı almıştır. Subtotal gastrektomi spesmeninde antrumda pos-terior duvar, küçük kurvatur yerleşimli 6.5 cm çapta ülseroinfiltratif tümör saptanmıştır. Histopatolojik incelemede kalın trabeküler yapılar oluşturan len¬fositten iri, yer yer belirgin nükleollü, sitoplâzmaları net olarak seçilemeyen, monomorfik, atipik hücrel¬erin oluşturduğu tümör izlenmiştir. Olgu mide medül-ler karsinomunun nadir görülmesi ve endoskopik biyopsilerde tanı güçlüğü oluşturması nedeniyle sunulmuştur.
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REFERENCES

References: 

1. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carci-noma. Acta Pathol Microbiol Scand 1965; 64:31-49.
2- Ming SC. Gastric carcinoma: a pathological clas-sification. Cancer 1977; 39: 2475-85.
3- Sugano H, Nakamura K, Kato Y. Pathological stu-dies of human gastric cancer.Acta PatholJpn. I982;32
Suppl 2:329-47.
4- Adachi Y, Yasuda K, inomata M, Sato K, Shiraishi N, Kitano S. Pathology and prognosis of the gastric carcinoma well versus poorly differantiated type. Cancer
2000; 89:I4I8-24.
5- Rodriguez A, Cejas HA, Martnez M, Cabral C. [Medullary carcinoma of the stomach]
Rev Fac Cien Med Univ Nac Cordoba. 2000;57: 59¬65
6- Takano Y, Kato Y. Epstein- Barr virus association with early cancers found together with gastric medul-lary carcinomas demonstrating lymphoid infiltration. J
Pathol I995; I75:39-44.
7- Takano Y, Kato Y, Sugano H. Epstein- Barr virus-associated medullary carcinoma with lymphoid infil-tration of the stomach. J Cancer Res Clin Oncol 1994;
I20:303-308.
8- Umedo T,SakamotoJ, Watanabe T, Ito K, Akimaya S, Yasue M, Takagi H. immunohistocemical analysis of the poorly differantiated stomach adenocarcinoma with medullary growth pattern. J Surg Oncol I996;
62:34-39.
9- Otsuji E, Kuriu Y, Ichikawa D, Ochiai T, Okamoto K, Hagiwara A, Yamagishi H. Clinicopathologic and prognostic characterization of poorly differentiated medullary-type gastric adenocarcinoma. World J Surg.
2004; 28:862-865.

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