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Boyun Yerleşimli Castleman Hastalığı

Castleman’s Dısease in The Neck

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Castleman’s disease is a rare lymphoproliferative disorder of unknown etiology exactly. Although the disease most commonly appears in the mediastinal lymph nodes, it can be occur in cervical, retroperitoneal, axillary and other regions lymph nodes. There is no gender predominance and often occurs in young adults. Two histological variants as hyaline-vascular and plasma cell type have been described. Clinically it is also divided in two types: a localized type, which is usually asymtomatic and presented as a mass or swelling. Systemic (multicentric) type is characterized nonspecific symptoms such as fever, anaemia, generalized lymphadenopathy and hepatosplenomegaly Complete surgical excision is curative for localized form. Although systemic type is usually treated with radiation therapy, corticosteroids and chemotherapy, there is no certain treatment. We herein reported a neck mass diagnosed as hyaline vascular type Castleman’s disease.
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Abstract (Original Language): 
Castleman hastalığı nadir görülen etiyolojisi tam olarak bilinmeyen lenfoprolifetif bir hastalıktır. En sık mediastinal lenf nodu tutulumu görülmekle birlikte servikal, retroperitoneal, aksiller ve diğer bölgelerdeki lenf nodları da tutulabilir. Sıklıkla genç erişkinlerde görülür ve cinsiyet ayırımı göstermez. Histopatolojik olarak hiyalin vasküler ve plazma hücreli olmak üzere iki tipi bulunmaktadır. Kliniğine göre de lokalize ve sistemik (multisentrik) formları bulunmaktadır. Lokalize tip genellikle asemptomatiktir ve kitle veya şişlik ile kendini gösterir. Sistemik (multisentrik) tipte ise ateş, anemi, yaygın lenfadenopati ve hepatosplenomegali gibi nonspesifik semptomlar görülür. Lokalize tip hastalığın tedavisi kitlenin cerrahi olarak eksizyonudur. Sistemik tip hastalığın tedavisinde genellikle steroid tedavisi, kemoterapi ve radyoterapi kullanılmasına rağmen kesin tedavisi yoktur. Bu çalışmada boyunda kitle şikâyeti ile gelen ve hiyalin vasküler tip Castleman hastalığı tanısı konulan bir olgu sunuldu.
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  • 4
153-155
  • Turkish

REFERENCES

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