Buradasınız

Anasayfa » Content

Helicobacter Pylori Eradikasyonunda Kıs a Süreli Uygulanan Dörtlü Tedavinin Etkinliği

Efficacy Of A Two Day Quadruple Therapy For Eradication Of Helicobacter Pylori

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
AIM: To find on effective short therapy regimen for eradication of Helicobacter pylori. MATERIALS AND METHODS: Patients who had upper gastrointestinal system complaints were evaluated by physical examination, laboratory, endoscopy and histopathological findings before and I month after treatment. Patients were given lansoprazole for 5 days and then tribismuthsubcitrate, ornida-z.ole and amoxicillin were added for two days. RESULTS: We obtained the eradication rate as 86.3 % in all patients. Eradication rates were determined as 100 % in patients with ulcer and 80 % in non-ulcer patients. Side effects were seen in only 3 patients (7.1 %). DISCUSSION: Many studies were he Id for eradication of Helicobacter pylori. Nowadays, short therapy regimens are preferable because of lesser side effects. If eradication rate is the same with the long term therapy, why do patients get drags for a long time? We found our eradication rate was similar so many of the studies. So, this therapy regimen can be used as it was an effective treatment.
Bookmark/Search this post with
Abstract (Original Language): 
AMAÇ: İki günlük dörtlü tedavinin Helicobacter pylori eradikasyonandaki etkinliğinin araştırılması. MATERYAL VE METOD: Aralık 1998-Temmuz 1999 tarihleri arasında Ankara Numune Hastanesi Gastroenteroloji Polikliniği'ne başvurup endoskopi endikasyonu konan hastalar, anamnez, fizik muayene, laboratuar bulguları, endoskopi ve lüstopatoloji sonuçları tedavi öncesi ve tedavi sonrası I. ayda değerlendirildi. Her hastaya beş gün 2*30mg/gün lansoprazol (Lansor, Sanovel) tedavisinden sonra, iki gün lansoprazolle birlikte tribizmutsubsitrat (De-Nol, Eczacibaşi) 4*300mg/gün, amoksisilin (Largopen, Bilim) 2*J000mg/gün ve ornidazol (Biteral, Roche) 2*500mg/gün uygulandı. SONUÇLAR: 36 hastanın 31 'inde (% 86.1) eradikasyon sağlandı. Eradikasyon oranı, tedavi öncesi endoskopik tanısı ülser olan II hastada % 100, gastrit olan 24 hastada % 83.3 olarak saptandı. Yan etki nedeniyle sadece 3 hastada (% 7.1) tedavi devam ettirilemedi. TARTIŞMA: Bu çalışmada saptanan eradikasyon oranları, diğer uzun ve kısa süreli tedavi yöntemlerine benzerlik göstermektedir. Bu nedenle, peptik ülser tedavisi ve Helicobacter pylori eradikasyonunda kolay uygulanabilen ve tedavi başarısı yüksek bir yöntem olarak kabul edilebilir.
FULL TEXT (PDF): 
PDF icon arastirmax-helicobacter-pylori-eradikasyonunda-kis-sureli-uygulanan-dortlu-tedavinin-etkinligi.pdf
  • 4
14-18
  • Turkish

REFERENCES

References: 

1. Kuipers EJ. Helicobacter pylori and the risk of management of associated diseases; gastritis, ulcer disease, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 1997; I(suppl) •Jl-88
2. Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroent 1989; 96: 6/5-625
3. Goodwin CS. Duodenal ulcer, Campylobacter pylori and the "leaking roof^ concept. Lancet 1988; 2: 1467-1469
4. Labenz J, Borsch G. Evidence for the essential role of Helicobacter pylori in gastric ulcer disease. Gut 1994; 35: 19-22
5. Sipponen P Kosunen TV, Valle J, et al. Helicobacter pylori infection and chronic gastritis in gastric cancer. J Clin Pathol 1992; 45: 319-323
6. Hogan RPH, Gummet PA, Schaufelberger HD, et al. Eradication of Helicobacter pylori with clarithromycin and omeprazole. Gut 1994; 35: 323-326
7. Rauws EAJ, Tytgat GNJ. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990; 335: 1233-1235
8. Glupczynski Y, Burette A, Labbe M, Deprez C, De Reuck M, Deltenre M. Campylobacter pylori-associated gastritis: A double blind placebo controlled trial with amoxycillin. Am J Gastroent 1988; 83: 365-372
9. Gilman R, Leon-Barva R, Ramirez-Ramos A, Morgan D, et al. Efficacy of nitrofurants in the treatment of antral gastritis with Campylobacter pyloridis. Gastroent 1987(abstract); 92: 1405
10. Bayerdorffer E, Simon TH, Bastlein CH, Ot-tenjann R, Kasper G. Bismuth! Ofloxacin combination for duodenal ulcer. Lancet 1987; 2: 1467-1468
11. Rauws EAJ, Tytgat GNJ. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990; 1: 1233-1235
12. Chiba N, Rao BV, Rademaker JW, et al. Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori. Am J Gastroent 1992; 87: 1716-1727
13. Labenz J, Gyen.es E, Peitz U, Borsch G. Ciprofloxacin-omeprazole treatment for eradication of Helicobacter pylori. Enferm Dig 1990(abstract); 78: 104
14. Logan RPH, Gummet PA, Misiewicz JJ, Karim QN, et al. One week eradication regimen for Helicobacter pylori. Lancet 1991; 2: 1249-1252
15. Rauws EAJ. Theraupetic attempts at eradication of Campylobacter pylori. Eur J Gastroenterol Hepatol 1992; 1: 34-41
17
Helicobacter Pylori Eradikasyonunda Kısa Süreli I Aydın, Köseoğlıı, Çetin
16. Mclaren A, McColm AA; Bangs/law J, et al. Eradication of Helicobacter pylori without antibiotics. Gut 1995(abstract); 37: A 63
17. Nagata K, Takagi E, Tsuda M, et al. Inhibitory action of lansoprazole and. its analogs against Helicobacter pylori: Inhibition of growth is not related to inhibition of urease. Antimicrob Agents Chemother 1995; 39: 567 570
18. Ripke H, Fuder H, Kleistl P, et al. Intragastric pH under various dosage regimens of lansoprazole as compared to a reference treatment with omeprazole. Gut 1995(abstract); 37: A 23
19. Soil AH. Parameters Committee of the American College of Gastroenterology. Medical treatment of peptic ulcer disease: Practice guidelines. JAMA 1996; 275: 622-629
20. de Boer WA, Driessen WMM, et al. Randomized study comparing I with 2 weeks of quadruple therapy for eradicating H.pylori. Am J Gastroent 1994; 89: 1993-/997
21. Rodionoff P, Hyland L, Ostapowicz N, et al. Triple therapy for H.pylori eradication- I, 2, 4 weeks? W Cong Gastroent 1990; Abstract p 938
22. Bayerdorffer E, Marines GA, Sommer A, et al. High dose omeprazole treatment combined with amoxicillin eradicates H pylori. Eur J Gastroenterol Hepatol 1992; 4: 697-702
23. de Boer WA. Treatment for Helicobacter pylori infection. J Clin Gastroent 1994; 19: 347-350
24. Tucci A, Poli L, et al. Weekend therapy for the treatment of helicobacter pylori infection. Am J Gastroent 1998; 93: 737-742
25. de Boer WA, Driessen WMM, Tytgat NJ. Only four days quadruple therapy can effectively cure Helicobacter pylori infection. Aliment Pharmacol Titer J 995; 9: 633-638
26. Hoben MHMG, van de Beek D, et al. Helicobacter pylori eradication therapy in Netherlands. Scand J Gastroenterol 1999; supp 230: 17-22
27. de Boer WA, va Etten. RJXM, Scliade RWB, et al. 4-Day lansoprazole quadruple therapy: A highly effective cure for Helicobacter pylori infection.'Am J Gastroent 1996; 91: 1778-1781
28. Whitaker CJ, Duhrel AJ, Galpin OP. Social and geographical risk factors in Helicobacter infection. Epidemiol Infec 1993; 111: 63-70
29. Blaser MJ. Role of vac A and the cag A locus of Helicobacter pylori in human disease. Aliment Pharmacol Titer 1996; 10: 73-77

Thank you for copying data from http://www.arastirmax.com