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AMANITA PHALLOİDES ZEHİRLENMESİNDE HEMOPERFÜZYON: İKİ OLGU TAKDİMİ

HEMOPERFUSION IN AMANITA PHALLOİDES POISONING: REPORT OF TWO CASES

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Abstract (2. Language): 
Amanita phalloides mushrooms are extremely toxic. Alpha-amanitin is an amatoxin known to produce deleterious effects on the liver and the kidneys, when circulating in the blood. Different therapeutic approaches are employed to treat mushrooms intoxication such as hemoperfusion, high doses of penicillin G, oral charcoal, force diuresis and liver transplantation. Two brothers with Amanita phalloides poisoning were admitted with gastrointestinal symptoms beginning ten hours following the ingestion. Neither of patients had hepatomegaly. Liver function tests were foundts be high in both of them. Hemoperfusion and supportive therapy were performed. Liver enzymes returned to the normal level after 20 days. Both children recovered from this fatal condition. The life saving role of early hemoperfusion in amanita phalloides is emphasized.
Abstract (Original Language): 
Amanita phalloides son derece toksik olan bir mantar türüdür. Amatoksin olarak bilinen toksini, zararlı etkilerini başlıca karaciğer ve böbrekler üzerinde oluşturmaktadır. Zehirlenen hastalarda hemoperfüzyon, hemodiyaliz, yüksek dozlarda penisilin, aktif karbon, zorlu diürez ve karaciğer transplantasyonu gibi tedavi yaklaşımları önerilmektedir. Mantar yenilmesinden yaklaşık on saat sonra gastrointestinal semptomlarla iki kardeş amanita phalloides entoksikasyonu tanısıyla kliniğimize yatırıldı. Vakalarımızda sanlık ve hepatomegali saptanmadı. Karaciğer fonksiyon testleri ve alkalen fosfataz yüksekti. Hastalarımıza destek tedavi ve hemoperfüzyon uygulandı. Karaciğer enzimleri 20. günde normale döndü. Amanita phalloides zehirlenmelerinde erken dönemde yapılan hemoperfüzyon hayat kurtarıcı olabilir.
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REFERENCES

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