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KRONİK HEMODİYALİZ HASTALARINDA NEOPTERİN SEVİYELERİ

NEOPTERIN LEVELS IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Both uremia and bioincompatibility of hemodialysis result in a chronic systemic inflammatory syndrome. There is evidence for the activation of monocytes and subsequent release of several proinflammatory cytokines in uremic patients. Neopterin is a low molecular weight product released by human macrophages upon stimulation with interferon gamma. It permits the quantification of the level of cellular immune activation in vivo. The aim of our investigation was to characterize neopterin levels in patients without systemic infection undergoing chronic dialysis therapy. Forty-six patients on chronic hemodialysis and 40 healthy controls were selected for the study on the basis of absence of any clinical evidence for infections during the last 3 weeks prior to the study. Our data show the presence of higher serum levels of neopterin in hemodialysed subjects with respect to the controls ( 53.9±17.8 vs 12.3±3.8 nmol/l; p<0.0001). On average the neopterin levels decreased from 53.9±17.8 nmol/l at baseline to 40.0±15.6 nmol/l at the end of hemodialysis (p<0.001). According to our results, raised neopterin levels before and after hemodialysis therapy confirm the presence of a chronic systemic inflammatory state in hemodialysis patients.
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Abstract (Original Language): 
ÖZET Üremik ortam ve hemodiyalizdeki biyouyumsuzluk kronik bir inflamasyona neden olmaktadır. Üremik hastalarda monosit aktivasyonu ve ardından çok sayıda proinflamatuar sitokinin salgılandığım gösteren deliller vardır. Neopterin interferon gama'nın stimülasyonu ile makrofajlardan salınan düşük molekül ağırlıklı bir üründür, in vivo olarak hücresel aktivasyon derecesi hakkında fikir verir. Bu çalışmada infeksiyon bulguları olmayan hemodiyaliz (HD) hastalarında serum neopterin seviyeleri araştırıldı. Kırk altı HD hastası ve 40 sağlıklı kontrol çalışmaya alındı. HD hastalarında neopterin seviyeleri kontrol grubuna göre daha yüksekti (53.9±17.8-12.3±3.8 nmol/l;p<0.0001). HD öncesi seviyelerde HD'den sonra kontrol grubuna göre yine yüksek olmakla birlikte (p<0.0001) anlamlı düşme oldu (53.9±17.8- 40.0±15.6nmol/l, p<0.001). Sonuçlarımıza göre, HD hastalarında neopterin seviyeleri diyaliz öncesi ve sonrası normalin üstündedir ve bu bulgular HD hastalarında kronik bir inflamasyon olduğunu destekler.
FULL TEXT (PDF): 
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  • 1
18-21
  • Turkish

REFERENCES

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