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Malign Hastalıkları n Seyrinde Böbreğin Etkilenmesi ve Kemoterapiye Bağlı ABY

Renal Abnormalities During Malignancies and Chemotherapy Related ARF

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Abstract (Original Language): 
Malign hastalıkları n seyrinde böbrek fonksiyonları çok çeşitli nedenlere bağlı olarak bozulabilir. Kemoterapi bu nedenlerden en sık rastlananıdır. Bu yazı, daha çok, kemoterapiye bağlı gelişen akut böbrek yetmezliği üzerine odaklanacaktır. Bununla beraber, kemoterapi, malign hastalıkların seyri esna¬sında böbrek fonksiyonlarının bozulmasının tek se¬bebi değildir. Malign hastalıkların seyrinde böbrek fonksiyon bozukluğunun nedeni malign hastalığın böbreği in-filtre etmesi veya tümörün bası etkisine bağlı idrar yo¬lu obstrüksiyonu gibi hastalığın doğrudan kendisine de bağlı olabilir. Bir diğer neden, neoplastik hücre yı¬kımının artmasına bağlı gelişebilecek tümör lizis sendromudur. Öte yandan malign hastalıklar, değişik mekanizmalarla gelişen hiperkalseminin sık rastlanan sebeplerinden biridir ve hiperkalsemi böbrek hasarı¬na yol açabilir.
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