Buradasınız

Anasayfa » Content

HEMODİYALİZ HASTALARINDA STANDART HEPARIN İLE DÜŞÜK MOLEKÜL AĞIRLIKLI HEPARİNİN KAN LİPİD DÜZEYLERİNE ETKİLERİNİN KARŞILAŞTIRILMASI

COMPARISON OF THE EFFECT OF MOLECULAR WEIGHT HEPARIN (LMWH) AND UNFRACTIONATED HEPARIN (UFH) ON PLASMA LIPOPROTEINS IN PATIENTS ON HEMODIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Patients undergoing maintenance hemodialysis therapy have increased mortality due to cardiovascu¬lar disease. One possible etiologic factor for this inc¬reased mortality are the lipid abnormalities associa¬ted with chronic renal failure. In this study the effects of low molecular weight heparin (LMWH) and con¬ventional unfractioned heparin (UFH) on plasma li-pids were investigated in hemodialysis patients. In a group of 10 patients who had been on chronic hemo-dialysis for longer than 20 months, UFH was repla¬ced by LMWH for 6 months. Baseline values of lipop-rotein profile prior to the intervention were compared with results obtained after 6 months of LMWH. Cont¬rol values were obtained 6 months after switching back to conventional heparin. During the LMWH tre¬atment total cholesterol, LDL-cholesterol and trigl-yceride levels decreased significantly. This coincided with a significant increase in HDL-cholesterol. After switching back again to conventional heparin, the li-poprotein parameters returned to starting values. We conclude that the long-term use of LMWH instead of conventional heparin for anticoagulation during di¬alysis may contribute to a reduction of the cardiovas¬cular risk factor of hemodialysis patients.
Bookmark/Search this post with
Abstract (Original Language): 
Hemodiyaliz uygulanan hastalarda kardiyovaskü-ler hastalıklara bağlı ölüm oranı oldukça yüksektir. Bunun nedenlerinden birisi de kronik böbrek yetmezli¬ği ile birlikte bulunan lipid metabolizması bozuklukla¬rıdır. Bu çalışmada hemodiyaliz hastalarında standart heparin (UFH) ile düşük molekül ağırlıklı heparin (LMWH)in kan lipid düzeylerine etkileri araştırıldı. 20 aydan uzun süredir UFH ile hemodiyaliz uygulanmakta olan 10 hastaya 6 ay süreyle LMWH verile¬rek, çalışmaya başlanmadan önceki bazal lipid pro¬filleri ile 6 ay sonunda elde edilen değerler karşılaş¬tırıldı. Bundan sonra tekrar 6 ay daha UFH tedavisi¬ne geri dönülerek kontrol değerleri oluşturuldu. LMWH tedavisi sırasında total kolesterol, LDL-koles-terol ve trigliserid düzeylerinde anlamlı düşüş, HDL-kolesterolde ise artış tespit edildi. Tekrar standart he-parin tedavisine başlandıktan sonra lipid profilleri başlangıç değerlerine geri döndü. Bu sonuçlara göre hemodiyalizde antikoagülasyon için standart heparin yerine LMWH'in uzun süre kullanımının kardiyovas-küler risk faktörlerini azaltabileceğini söyleyebiliriz.
FULL TEXT (PDF): 
PDF icon pdf_tndt_100.pdf
  • 3
151-154
  • Turkish

REFERENCES

References: 

1. Guljarro C, Keane WF. Lipid abnormalities and Changes in plasma proteins in glomerular diseases and chro¬nic renal failure. Current Opinion in Nephrology and Hypertension 1993; 2: 372-379.
2. Kasiske BL, Keane WF. Causes, consequences and tre¬atment of hyperlipidemia in patients with renal disease. Second Annual Spring Nephrology Meeting of The
NKF, April 22-25 Chicago, 1993
3. Attmen PO, Alaupovic P. Lipid abnormalities in chronic renal insufficiency. Kidney Int 1991; 31: 16-23.
4. Attmen PO, Alaupovic P. Lipid and apolipoprotein pro¬files of uremic dyslipoproteinemia: relation to renal function and dialysis 1991; 57: 403-410.
5. Anderson S, Garcia DL, Brenner BM. Renal and syste¬mic manifestations of glomerular disease. In: (Brenner
BM, Rector FC, (eds). The Kidney WB Saunders Com¬pany , Philadelphia; 1991, p. 1854.
6. Cosmi B, Hirs J. Low molecular weight heparins. Cur¬rent Opinion in Cardiology 1994; 9: 612-618.
7.
Keski
n A, Cirit M, Karaca E, Başçı A, Büyükkeçeci F. Hemodiyalizde düşük molekül ağırlıklı heparin ile stan¬dart heparinin karşılaştırılması. Türk Hematoloji Onko¬loji Dergisi 1994; 3: 171-175.
8. Schrader J, Anderson LO, Armstrong VW, et al. Lipoly-tic effect of heparin and low moleculer weight heparin and their importance in hemodialysis. Semin Thromb
Haemost 1990; 16: 41-45.
9. Chan MK, Persaud J, Varghese Z, Moorhead JF. Patho¬genic roles of post heparin lipazes in lipid abnormalities
in hemodialysis patients. Kidney Int 1984; 25:812-818.
10. Rostand SG, Kirk KA, Rutsky EA. Dialysis-Associated ischemic heart disease: Insights from coronary angiog-
raphy. Kidney Int 1984; 25: 653-659.
11. Charney DI, Walton DF, Cheung AK. Atherosclerozis in chronic renal failure. Current Opinion in Nephrology
and Hypertension 1993; 2: 876-882.
12. Lindler A, Charra B, Donald JS, Belding HS. Accelera¬ted atherosclerosis in prolonged maintenance hemodi-alysis. New Eng J Med 1974; 13: 697-700.
13. Deuber HJ, Schulz W. Reduced lipid concentrations du¬ring four years of dialysis with low molecular weight he-
parin. Kidney Int 1991; 40: 496-500.
14. Schimtt Y, Schneider H. LMWH. Influence on blood li-
pids in patients on chronic haemodialysis. Nephro Dial
Transplant 1993; 8: 438-442.
15.
Collan
d TH, Guelpa G, Riesen W, Robert D. Effect on the lipid metabolism of conventional heparin treatment and low molecular weight heparin in hemodialysis pati¬ents. Kidney Int 1987; 32: 433-438.
16. Goldberg AP, Hagberg JM, Delmer JA. Metabolic effects of exercise training in hemodialysis patients. Kid¬ney Int 1980; 18: 754-761.
17. Josephson MA, Fellner SK, Dasgupta A. Improved lipid profiles on patients undergoing high-flux hemodialysis.
Am J Kid Dis 1992; 4: 361-366.
18. Hamazaki T, Nakazawa R, Tateno S, et al. Effects of fish oil rich in eicosapentaenoic acid on serum lipid in hyperlipidemic hemodialysis patients. Kidney Int 1984;
26: 81-84.

Thank you for copying data from http://www.arastirmax.com