You are here

Home » Content

Investigation of Antisecretory activities of Imidazo[1,2,a]pyridinylethylbenzoxazoles with the Electron Topological Method (ETM)

Journal Name:

  • Cumhuriyet Üniversitesi Fen Fakültesi Fen Bilimleri Dergisi

Publication Year:

  • 2002
Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Relationship structure-antisecretory of a series of Imidazo[1,2,a]pyridinylethyl benzoxazole derivatives which is known to be either active-inactive or their activity which is known quantitatively are investigated theoretically with Electron Topological Method (ETM). This technique can identify active fragment, related activity, belongs to the series of compounds and can quantitatively give the values of some compounds whose secretion activities cannot be measured experimentally. For 47 compounds, conformational analysis and quantum chemical calculations were done, and unit matrix representing electronic character was calculated, and active fragment in the active compounds were extracted.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastrmx_32114_23_pp_16-30.pdf
  • 1
16-30
  • English

REFERENCES

References: 

1. Y. Katsura, Y. Inoue, S. Nishino, M. Tomai and H. Takasugi, Chem. Pharm. Bull., 40, 371(1992).
2. G. J. Durant, J. C. Emmett, C. R. Ganellin, P. D. Miles, M. E. Parsons, H. D. Prain and G.
R. White, J. Med. Chem., 20, 901(1977).
3. J. Bradshaw, R. T. Brittain, J. W. Clitherow, M. J. Daly, D. Jack, B. J. Price and R. Stables,
Brit. J. Pharmacol., 66, 464(1979).
4. T. M. Lin, D. C. Evans, M. W. Warrick, R. P. Pioch and R. R. Ruffolo,
Gastroenterology, 84, 123(1983).
5. I. Yanagisawa, Y. Hirata and Y. Ishii, J. Med. Chem., 30, 1787(1987).
6. E. Barocelli, M. Chiavarini, V. Ballabeni, D. Barlocco, P. Vianello, V. Dal Piaz, M. Impicciatore, Pharmacological Reseacrh, 35(5), 487-492(1997).
7. Y. Kawanishi, S. Ishihara, R. Kiyama, S. Hagishita, T. Tsushima, M. Ishikawa, Y. Ishihara, Bioorganic and Medicinal Chemistry, 5(7), 1425-1431(1997).
8. R.H. Hunt, C. Cederberg, J. Dent, F. Halter, C. Howden, I. N. Marks, S. Rune, R. P. Walt,
Digestive Diseaseand Science., 40(2 suppl):24S-49S, (1995).
9. I. B. Bersuker and A. S. Dimoglo, Reviews in Computational Chemistry II, 423-460
(1990).
10. Y. Guzel, E. Saripinar and I. Yildirim, J. Molecular Structure (Theochem), 418, 83-
91(1998).
11. James O. Jensen Spectrochimica Acta Part A 59 (2003) 379-392.
12. K.A. Wiberg , Tetrahedron 24 (1968) 1083.
13. Jimmy Rosen , armin Robobi , Per-Georg Nyhalm Carbohydrate Research 337 (2002)1633-1640.

Thank you for copying data from http://www.arastirmax.com