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Rekürren maternal CMV enfeksiyonları ne kadar masum? Sitomegalik inklüzyon hastalığı olan bir yenidoğanın sunumu

How much innocent are recurrent maternal CMV infections? A case report of a newborn with cytomegalic inclusion disease

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2008

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Abstract (2. Language): 
It is known that cytomegalic inclusion disease due to congenital CMV infection almost always occurs after a primary infection of the mother during her pregnancy who has not preconceptual immunity, and screening tests mainly aim to identify these primary infections. However, it has been reported that there are no significant differences in the incidence of cytomegalic inclusion disease, clinical presentation of the disease and rate of long-term sequela occuring after primary or recurrent maternal infection. By presenting cytomegalic inclusion disease which developed in the newborn of a mother with preconceptual immunity in this article, we aimed to emphasize that recurrent maternal CMV infection may result in serious problems on the contrary to the common knowledge. Additionally we aimed to point out the necessity of making screening tests in a manner to identify maternal primary as well as recurent infections in countries like ours in where seroprevalence of CMV approaches to 100% in early ages.
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Abstract (Original Language): 
Konjenital CMV enfeksiyonuna bağlı sitomegalik inklüzyon hastalığının hemen her zaman, gebelik öncesinde CMV immünitesi olmayan bir annenin gebeliği sırasında geçirdiği primer bir enfeksiyon sonucu oluştuğu bilinmektedir ve tarama testleri de daha çok bu primer enfeksiyonu saptamayı amaçlamaktadır. Bununla birlikte, primer veya rekürren maternal enfeksiyon sonucu sitomegalik inklüzyon hastalığı oluşması insidansında, hastalığın ortaya çıkış kliniğinde ve uzun süredeki sekel oranında anlamlı bir fark olmadığı da bildirilmektedir. Bu yazıda, gebeliği öncesinde CMV immünitesi olan bir annenin yenidoğanında ortaya çıkan sitomegalik inklüzyon hastalığını sunarak, rekürren maternal CMV enfeksiyonunun bilinenin aksine önemli sonuçlar doğurabileceğini vurgulamayı amaçladık. Ayrıca ülkemiz gibi CMV seroprevalansının erken yaşlarda %100'e ulaştığı ülkelerde, tarama testlerinin primer kadar rekürren maternal CMV enfeksiyonlarını da saptamayı amaçlayacak şekilde yapılmasının gerektiğine dikkat çekmek istedik.
FULL TEXT (PDF): 
PDF icon arastirmax-rekurren-maternal-cmv-enfeksiyonlari-ne-kadar-masum-sitomegalik-inkluzyon-hastaligi-olan-bir-yenidoganin-sunumu.pdf
  • 1
34-38
  • Turkish

REFERENCES

References: 

1. Spector SA. Bacterial and viral infections. In: Rudolph
AM, Hoffman JIE, Rudolph CD (eds). Rudolph's
Pediatrics. 20th ed. Stanford: Appleton&Lange, 1996:
629-633.
2. Griffiths PD, Walter S. Cytomegalovirus. Curr Opin
Infect Dis 2005; 18: 241-245.
3. Senok AC, Giacometti L, Giuseppe AB. Human
cytomegalovirus infections in pregnancy and the newborn: epidemiology, laboratory diagnosis and medicolegal aspects. J Kuwait Med Assoc 2006; 38: 85-93.
4. Skaletskaya A, Bartle LM, Chittenden T, McCormick AL,
Mocarski ES, Goldmacher VS. A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. Proc Natl Acad Sci USA 2001; 98: 7829-7834.
5. Arnoult D, Bartle LM, Skaletskaya A, et al.
Cytomegalovirus cell death suppressor vMIA blocks
baxbut not bak-mediated apoptosis by binding and
sequestering bax at mitochondria. Proc Natl Acad Sci
USA 2004; 101: 7988-7993.
6. Revello MG, Gerna G. Diagnosis and management of
human cytomegalovirus infection in the mother, fetus,
and newborn infant. Clin Microbiol Rev 2002; 15: 680-
715.
7. Ornoy A, Diav-Citrin O. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod
Toxicol 2006; 21: 399-409.
8. Hizel S, Parker S, Onde U. Seroprevalence of cytomegalovirus infection among children and females in
Ankara, Turkey, 1995. Pediatr Int 1999; 41: 506-509.
9. Schleiss MR. Cytomegalovirus infection. eMedicine
Specialties, Pediatrics, Infectious Diseases. February 18,
2005.
10. Munro SC, Hall B, Whybin LR, et al. Diagnosis of and
screening for cytomegalovirus infection in pregnant
women. J Clin Microbiol 2005; 43: 4713-4718.
11. Rutter D, Griffiths P, Trompeter RS. Cytomegalic inclusion disease after recurrent maternal infection. Lancet
1985; 23: 1182.
12. Morris DJ, Sims D, Chiswick M, Das VK, Newton VE.
Symptomatic congenital cytomegalovirus infection after
maternal recurrent infection. Pediatr Infect Dis J 1994;
13: 61-64.
13. Boppana SB, Rivera LB, Fowler KB, Mach M, Britt WJ.
Intrauterine transmission of cytomegalovirus to infants of
women with preconceptional immunity. N Engl J Med
2001; 344: 1366-1371.
14. Ahlfors K, Ivarsson SA, Harris S. Report on a long-term
study of maternal and congenital cytomegalovirus infection in Sweden. Review of prospective studies available in
the literature. Scand J Infect Dis 1999; 31: 443-457.
15. Gaytant MA, Steegers EAP, Semmekrot BA, et al.
Congenital cytomegalovirus infection: review of the epidemiology and outcome. Obstet Gynecol Surv 2002; 57:
245-256.
16. Stagno S. Cytomegalovirus. In: Remington JS, Klein JO
(eds). Infectious Diseases of the Fetus and Newborn
Infant. Philadelphia: WB Saunders Co, 2001: 389-424.
17. Lazzarotto T, Spezzacatena P, Pradelli P, Abate DA,
Varani S, Landini MP. Avidity of immunoglobulin G
directed against human cytomegalovirus during primary
and secondary infections in immunocompetent and
immunocompromised subjects. Clin Diagn Lab
Immunol 1997; 4: 469-473.
18. Nielsen SL, Sorensen I, Andersen HK. Kinetics of specific immunoglobulins M, E, A, and G in congenital, primary, and secondary cytomegalovirus infection studied by
antibody-capture enzyme-linked immunosorbent assay. J
Clin Microbiol 1988; 26: 654-661.
19. Nigro G, Adler SP, La Torre R, Best AM; Congenital
Cytomegalovirus Collaborating Group. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 2005; 353: 1350-1362.
20. Adler SP. Congenital cytomegalovirus screening. Pediatr
Infect Dis J 2005; 24: 1105-1106.

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