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Çevresel Sigara Dumanının 7-10 Yaş Grubu Çocuklarda Testis Fonksiyonlarına Etkisi

The Effect of Environmental Tobacco Smoke on the Testicular Functions of 7-10 Years Old Children

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2012

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Purpose: To investigate the effect of environmental tobacco smoke (ETS) on the testicle functions of 7-10 years old children. Materials and Methods: The study included healthy male children aging between 7-10 years. Based on the questionnaire data, 50 passive smoking (PS) cases and 50 passive smoking free controls were determined. Serum levels of cotinine, and biochemical parameters of the testicle functions; testosterone, inhibin B, anti-mullerian hormone (AMH) along with FSH and LH levels were evaluated. Results: Serum cotinine levels in PS group were found higher than the controls (p<0,05). Testosterone, inhibin-B, FSH, and LH levels of the control group was found higher than the PS group. The AMH levels were found lower in the controls in comparison with the PS group (p<0,05). Conclusions: Our results showed that ETS leads to testicular dysfuntions. We think that preventing exposure to cigarette smoke in childhood is very important for their reproductive system.
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Abstract (Original Language): 
Amaç: Pasif içicilik olarak tanımlanan çevresel sigara dumanına maruz kalma sık karşılaşılan bir durumdur. Bu çalışma ile pasif sigara içicisi durumunda olan 7–10 yaş grubu çocuklarda çevresel sigara dumanının testis fonksiyonları üzerindeki etkisini incelemeyi amaçladık. Gereç ve Yöntem: Çalışmaya ilköğretim okullarında okuyan, 7-10 yaş grubunda ek bir sağlık problemi olmayan erkek çocuklar dahil edildi. Pasif sigara içicisi durumunda olan (Pİ) 50 olgu ve olmayan (K) 50 olgu anket çalışmasıyla belirlendi. Belirlenen olguların serumlarından kotinin düzeyleri ile testis fonksiyonunun biyokimyasal göstergeleri olan testosteron, inhibin-B, anti-müllerian hormon (AMH) ile beraber FSH ve LH düzeyleri çalışıldı. Bulgular: Pİ grubunda serum kotinin düzeyleri K grubuna göre belirgin artmış bulundu (p<0,05). Testosteron, inhibin-B, FSH, LH düzeyleri K grubunda Pİ grubuna göre belirgin olarak yüksek bulunurken; bu yaş grubunda testosteron ile ters orantılı hareket eden AMH seviyelerinin K grubunda Pİ grubuna göre düşük olduğu saptandı (p<0,05). Sonuç: Elde ettiğimiz sonuçlar çevresel sigara dumanının testislerde fonksiyon bozukluğuna yol açtığını göstermektedir. Bunun da erişkin yaşlarda ortaya çıkabilecek infertiltenin nedenlerinden birisi olabileceği düşünülmektedir.
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  • 1
9-13
  • Turkish

REFERENCES

References: 

1. World Health Organization. Tobacco Free Initiative.
International Consolation on Environmental Tobacco
Smoke and Child Health Report. Geneva: WHO; 1999.
2. Ersu R, Arman A, Save D, et al. Prevalence of Snoring
and Symptoms of Sleep-Disordered Breathing in Primary
School Children in Istanbul. Chest 2004; 126: 19-24 .
DOI: 10.1378/chest.126.1.19
3. Erguder T, Soydal T, Uğurlu M, et al. Tobacco Use
Among Youth and Related Characteristics, Turkey. Soz
Preventiv Med 2006; 51: 91-8. DOI: 10.1007/s00038-005-
0020-x
4. Avşar A, Darka O, Bodrumlu EH, et al. Evaluation of the
Relationship Between Passive Smoking and Salivary
Electrolytes, Protein, Secretory IgA, Sialic Acid and
Amylase in Young Children. Arch Oral Biol 2009; 549;
457-63.
5. Henderson AJ. The Effects of Tobacco Smoke Exposure
on Respiratory Health in School-Aged Children. Paediatr
The Effect of Environmental Tobacco Smoke on the Testicular Functions of 7-10 Years Old Children
13
Respir Rev 2008; 9: 21-7. DOI:
10.1016/j.prrv.2007.11.005
6. Delpisheh A, Kelly Y, Brabin BJ. Passive Cigarette Smoke
Exposure in Primary School Children in Liverpool. Public
Health 2006; 120(1): 65-9. DOI:
10.1016/j.puhe.2005.05.003
7. Zalata A, Yahia S, Ed-Bakary A, et al. Increased DNA
Damage in Children Caused by Passive Smoking as
Assessed by Comet Assay and Oxidative Stress. Mutat
Res 2007; 629: 140-7.
8. Janson C. The Effect of Passive Smoking on Respiratory
Health in Children and Adults. Int J Tuberc Lung Dis
2004; 8: 510-6.
9. Tang D, Warburton D, Tannenbaum SR, et al. Molecular
and Genetic Damage from Environmental Tobacco
Smoke in Young Children. Cancer Epidemiol Biomarkers
Prev 1999; 8: 427-31.
10. Tutka P, Wielosz M, Zatoński W. Exposure to
Environmental Tobacco Smoke and Children Health. Int
J Occup Med Environ Health 2002; 159: 325-35.
11. Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, et al.
Is Smoking a Risk Factor for Decreased Semen Quality?
A Cross-Sectional Analysis. Hum Reprod 2007; 22: 188-
96. DOI: 10.1093/humrep/del364
12. Trummer H, Habermann H, Haas J, et al. The Impact of
Cigarette Smoking on Human Semen Parameters and
Hormones. Hum Reprod 2002; 17: 1554-9. DOI:
10.1093/humrep/17.6.1554
13. Yardimci S, Atan A, Delibasi T, et al. Long- Term Effects
of Cigarette-Smoke Exposure on Plasma Testosterone,
Luteinizing Hormone and Follicle-stimulating Hormone
Levels in Male Rats. Br J Urol 1997; 79: 66-9. DOI:
10.1046/j.1464-410X.1997.28314.x
14. Ahmadnia H, Ghanbari M, Moradi MR, et al. Effect of
Cigarette Smoke on Spermatogenesis in Rats. Urol J 2007;
4: 159-63.
15. Jarvis MJ, Russell MA, Benowitz NL, et al. Elimination of
Cotinine from Body Fluids: Implications for Noninvasive
Measurement of Tobacco Smoke Exposure. Am J Public
Health 1988; 78: 696-8. DOI: 10.2105/AJPH.78.6.696
16. Oddoze C, Dubus JC, Badier M, et al. Urinary Cotinine
and Exposure to Parental Smoking in a Population of
Children with Asthma. Clin Chem 1999; 45: 505-9.
17. Richthoff J, Elzanaty S, Rylander L, et al. Association
Between Tobacco Exposure and Reproductive
Parameters in Adolescent Males. Int J Androl 2008; 31:
31-9.
18. Chohan KR, Badawy SZ. Cigarette Smoking Impairs
Sperm Bioenergetics. Int Braz J Urol 2010; 36: 60-5. DOI:
10.1590/S1677-55382010000100010
19. Sofikitis N, Miyagawa I, Dimitriadis D, et al. Effects of
Smoking on Testicular Function, Semen Quality and
Sperm Fertilizing Capacity. J Urol 1995; 154: 1030-4.
DOI: 10.1016/S0022-5347(01)66968-4
20. Yamamoto Y, Isoyama E, Sofikitis N, et al. Effects of
Smoking on Testicular Function and Fertilizing Potential
in Rats. Urol Res 1998; 269: 45-8. DOI:
10.1007/s002400050022
21. Willers S, Skarping G, Dalene M, et al. Urinary Cotinine
in Children and Adults During and After
Semiexperimental Exposure to Environmental Tobacco
Smoke. Arch Environ Health 1995; 50: 130-8. DOI:
10.1080/00039896.1995.9940890
22. Crofton PM, Thomson AB, Evans AE, et al. Is Inhibin B
a Potential Marker of Gonadotoxicity in Prepubertal
Children Treated for Cancer? Clin Endocrinol 2003; 58:
296-301. DOI: 10.1046/j.1365-2265.2003.01712.x
23. Young J, Rey R, Couzinet B, et al. Antimüllerian
Hormone in Patients with Hypogonadotropic
Hypogonadism. J Clin Endocrinol Metab 1999; 84: 2696-
9. DOI: 10.1210/jc.84.8.2696
24. Andersson AM, Skakkebaek NE. Serum Inhibin B Levels
During Male Childhood and Puberty. Mol Cell
Endocrinol 2001; 30: 103-7. DOI: 10.1016/S0303-
7207(01)00520-2
25. Sharpe RM, McKinnell C, Kivlin C, et al. Proliferation
and Functional Maturation of Sertoli Cells, and Their
Relevance to Disorders of Testis Function in Adulthood.
Reproduction 2003; 125: 769-84. DOI:
10.1530/rep.0.1250769
26. Güven MC, Can B, Ergün A, et al. Ultrastructural Effects
of Cigarette Smoke on Rat Testis. Eur Urol 1999; 36:645-
9. DOI: 10.1159/000020061
27. Zhang J, Liu Y, Shi J, et al. Side-stream Cigarette Smoke
Induces Dose-response in Systemic Inflammatory
Cytokine Production and Oxidative Stress. Exp Biol Med
2002; 227: 823-9.
28. Kosecik M, Erel O, Sevinc E, et al. Increased Oxidative
Stress in Children Exposed to Passive Smoking. Int J
Cardiol 2005; 8: 61-4. DOI: 10.1016/j.ijcard.2004.05.069
29. Ozyurt H, Pekmez H, Parlaktas BS, et al. Oxidative Stress
in Testicular Tissues of Rats Exposed to Cigarette Smoke
and Protective Effects of Caffeic Acid Phenethyl Ester.
Asian J Androl 2006; 8: 189-93. DOI: 10.1111/j.1745-
7262.2006.00119.x
30. Raychoudhury SS, Kubinski D. Polycyclic Aromatic
Hydrocarbon-Induced Cytotoxicity in Cultured Rat
Sertoli Cells Involves Differential Apoptotic Response.
Environ Health Perspect 2003; 111: 33-8. DOI:
10.1289/ehp.5458

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