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Overektomize ve Uni-böbrekleri Sıçanlarda Akut Renal İskemi için Renin Aktivitesi Yanıt ramipril (ACE inhibitörü) etkisi

Effect of Ramipril (ACE inhibitor) on Renin Activity Response to Acute Renal Ischemia in the Ovariectomized and Uni-nephrectomized Rats

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Renin-angiotensin system is thought to be modulated by gonadal steroids. However, it has not been well established whether gonadal steroids also modulate the changes in plasma renin activity (PRA) occuring in response to stimuli such as acute renal ischemia and also the effects of angiotensin-converting enzyme (ACE) on PRA. The aim of the present experiment was to study the relationship between sex hormones and plasma renin activity during acute renal ischemia in the Wistar rats. For this purpose, ovariectomy was performed in some rats and the changes in PRA in response to acute renal ischemia were observed. The levels of serum aldosterone and electrolytes were a/so measured. Ovariectomy not only caused a decrease in PRA but also reduced PRA response to acute renal ischemia. In contrast, ovariectomy had a reverse effect increasing PRA activity when ramipril, an ACE inhibitor, was used to prevent excessive angiotensin II formation due to renal ischemia. In conclusion, it can be said that gonadal steroids may have a role in modulating the PRA response to acute renal ischemia and may lead to changes in the effect of ACE inhibitors.
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Abstract (Original Language): 
Renin-anjiotensin sistemi gonadal steroidler ile modüle olduğu düşünülmektedir. Ancak, iyi gonadal steroidler ayrıca akut böbrek iskemi gibi uyaranlara yanıt olarak oluşan plazma renin aktivitesinde değişiklikler (PRA) modüle ve PRA üzerindeki anjiyotensin dönüştürücü enzim (ACE) etkilerinin olup olmadığı kanıtlanmamıştır.Bu deneyin amacı Wistar sıçanlarda akut böbrek iskemi sırasında seks hormonları ve plazma renin aktivitesi arasındaki ilişkiyi incelemektir. Bu amaç için, ovariektomi bir sıçana, ve akut böbrek iskemi yanıt olarak PRA olarak değişiklikler gözlendi. Serum aldosteron ve elektrolit düzeyleri / öylesine ölçüldü. Ovariektomi yalnızca PRA azalma değil, aynı zamanda akut renal iskemi azaltılır PRA yanıtı neden olmaz. Buna karşılık, overektomi bir ters etkisi ramipril, bir ACE inhibitörü, renal iskemi nedeniyle aşırı anjiyotensin II oluşumunu engellemek için kullanılan zaman PRA aktivitenin artırılması vardı. Sonuç olarak, gonadal steroidlerin akut renal iskemi modüle PRA cevabı bir role sahip olabilir ve ACE inhibitörlerinin etkisi değişikliklere yol açabileceği söylenebilir.
FULL TEXT (PDF): 
PDF icon arastirmax-overektomize-uni-bobrekleri-sicanlarda-akut-renal-iskemi-icin-renin-aktivitesi-yanit-ramipril-ace-inhibitoru-etkisi.pdf
  • 1
7-11
  • Turkish

REFERENCES

References: 

1. DeVito E, Guardia DC, Cabrera RR. Cyclical changes in plasma renin during the oestrous in the rat: synchronized effect of oestrogen and progesterone. J Endocrinol 1989; 121 (2): 261-7.
2. McAreavey D, Cumming AMM, Boddy K. et al. The renin-angiotensin system and total sodium and potassium inhypertensive women taking oestrogen-progestagen oral contraceptives. Clin Endocrinol 1983; 18: 111-8.
3. Evans JK, Naish PF, Aber GM. Oestrogen-induced changes in renal haemodynamics in the rat: influence of plasma and intrarenal renin. Clin Sci 1986; 71 (5): 613-9.
4. Plouin Pf, Chatellier G, Guyene TT, Vincent N, Corvol P. Recent advances in the clinical study of the renin system. Presse-Med 1989; 18 (18): 917-21.
5. Whithworth JA, Scoggins BA, Andrews J, Williamson PM, Brown MA. Haemodynamic and metabolic effects of short term administration of synthetic sex steroids in humans. Clin Exp Hypertens A 1992; 14(5): 905¬22.
6. McDougal WS Renal perfusion / Reperfusion injuries. J Urol 1988; 140: 1325-30.
7. Remuzzi A, Benigni A. Malanchini B. Bruzzl I, Foglieni C, Remuzzi G. ACE inhibition prevents renal failure and death in uninephrectomized MWF/Ztm rats Kidney Int 1995; 47: 1319-26.
8. Magnusson MO, Rybka SJ, Stowe NJ, Novick AC, Straffon RA. Enhancement of recovery in postischemic acute renal failure with captopril. Kidney Int., suppl. 1983; 16 24: S324.
9. Schricker K, Holmer S, Kramer K, Riegger G, Kurtz A. Control of renin gene expression in 2 kidney-1 clip rats. Kidney International 1994; 46: 1539-41.
10. Barthelmebs M, Stephan D, Krieger JP, Grima M, Imbs JL. Stereoselective renal effects of the loop diuretic ozolinone in the anesthetized dog. Naunyn Schmiedebergs Arch Pharmacol. 1995; 351 (6): 660¬71.
11. Proudler AJ, Ahmed Al, Crook D, Fogelman I, Rymer JM, Stevenson JC. Hormone replacement therapy and serum angiotensin-converting enzyme activity in postmenopausal women. Lancet 1995; 346: 89.
12. Keller-Wood M, Wood CE. Effect of ovariectomy on vasopressin, ACTH, and renin activity responses to hypotension. Am J Physiol 1991; 261 (1 Pt 2): R223-30.
13. Omosu M. Studies on the mechanism of action of angiotensin converting enzyme inhibitors on the dog kidney. Nippon Jinzo Gakkai Shi 1992; 34 (8): 883-94.

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