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UZUN SÜRELİ LİTYUM KULLANIMININ TİROİD FONKSİYONLARI ÜZERİNE ETKİLERİ

Long-term effect of lithium on thyroid functions

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Purpose: To evaluate the long-term effects of lithium, widely used in the treatment of bipolar affective disorders, on thyroid functions. Materials and method: Twenty two patients with the diagnosis of bipolar affective disorders according to the criteria of DSM-IV formed the study group and 10 healthy volunteers were included in the control group. Mean lithium usage period in the study group was 3.5±2.6 years. Free T3 and T4 levels were measured with High Sensitive RIA and TSH levels were measured with IRMA-CAUNT method. Findings: There was no significant difference between the two groups in terms of free T3 and TSH levels; whereas, free T4 levels were significantly lower in the study group. Discussion: The effects of lithium treatment on thyroid functions have been known for a long time. A lot of studies have been designed to show its goitre inducing effects. In this situation, it is necessary to add thyroid hormones to the treatment or to choose alternative prophylactic measures during the treatment.
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Abstract (Original Language): 
Amaç: Bipolar affektif bozuklukta yaygın olarak kullanılan lityumun, tiroid fonksiyonları üzerine uzun süreli etkilerini araştırmak. Yöntem: Çalışma grubu; DSM-IV kriterlerine göre bipolar affektif bozukluk tanısı almış 22 hasta ve 10 sağlıklı gönüllüden oluştu. Hasta grubunun lityum kullanma süresi 3.5±2.59 yıl idi. Deneklerin sT3, sT4 değerleri High Sensitivity RIA, TSH değerleriIRMA-CAUNTmetodu ile ölçüldü. Bulgular: Değerlerin analizi sonucunda sT3, TSH değer/eri arasında fark bulunamazken sT4 değerleri arasında anlamlı fark bulundu. Tartışma.-Lityumun tiroid fonksiyonları üzerine bozucu etkileri uzun zamandır bilinmektedir. Özellikle guatr yapıcı etkileri bir çok çalışmayla gösterilmiştir. Böyle bir durum oluştuğunda tedaviye tiroid hormonları eklenmeli veya alternatif prof/aktık tedavi/erin seçilmesi uygun bir yol olduğu düşünülmektedir.
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  • 4
261-263
  • Turkish

REFERENCES

References: 

1. Mori M, Tajima K, Oda Y, et al. Inhibitory effect of lithium on the release of thyroid hormones from thyrotropin-stimulated mouse thyroids in a perifusion system. Endocrinology 1989;124:1365-69.
2. Bocchetta A, Bernard! F, Pedditzi M, et al. Thyroid abnormalities during lithium treatment. Acta Psychiatr Scand 1991; 83:1938.
3. Solaris S, Margarity M, Valcana T. Effects of LiCI on triiodothyronine binding to nuclei from rat cerebral hemispheres.Biol Psychiatry 1993; 37:106-111.
4. Barclay ML, Sevan E, Brownlie W, et al. Lithium associated thyrotoxicosis: a report of 14 cases, with statistical analysis of incidence. Clinical Endocrinology 1994; 40:759-764.
5. Stratakis CA, Chrousos GP. Trasient elevation of serum thyroid hormone levels following lithium discontinuation. Eur J Pediatr 1996; 155:939-941
6. Gittoes NJ, Franklyn JA. Drug-induced thyroid disorders. Drug Saf 1995; 13:1: 46-55.
7. Weber E, Coche E. Hyperthyroidism after lithium withdrawal: coincidence or not?. Rev Med Interne 1995; 16:437-9.
8. Leutgeb U. Lithium and its effect on the endocrine system, bones and peripheral nerves. Fortschr Neurol Psychiatr 1995; 63: 149-161.
9. Bocchetta A, Bernardi F, Burrai C, et al. The course of thyroid abnormalities during lithium treatment: a two-year folow-up study.Acta Psychiatr Scand 1992; 86:38-41.
10. Terao T, Oga T, Nozaki S, et al. Possible inhibitory effect of lithium on peripheral conversion of thyroxine to triiodothyronine: a prospective study. IntClin Psychopharmacol 1995;10:103-5.
11. Baumgartner A, Stuckrad M, Müller-Oerlinghausen B, et al.The hypothalamic-pituitary- thyroid axis in patients maintained on lithium prophylaxis for year: high triiodothyronine serum concentrations are correlated to the prophylactic efficacy. J Affect Disord 1995;34: 211-28.

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