You are here

Home » Content

In silico modeling for Identification of promising antimicrobials of Herbal origin against highly virulent pathogenic strains of bacteria like New Delhi Metallo-beta-lactamase -1 Escherichia coli

Journal Name:

  • International Journal of Innovation and Applied Studies

Publication Year:

  • 2013

Keywords (Original Language):

Author Name
Bookmark/Search this post with
Abstract (Original Language): 
Drug resistance has mushroomed up after advent of every major class of antimicrobial drugs, varying in time from as short as 1 year (penicillin) to >10 years. Organisms associated with nosocomial and community acquired infections are also becoming drug resistant due to the over utilization of antibiotics, consequently leading to high morbidity, mortality and increased health costs. One such example of a beta lactamase producing bacteria is New Delhi Metallo beta lactamase (NDM- 1) producing Escherichia coli and Klebsiella pneumoniae, and was reported for the first time in the year 2009 in a Swedish patient. NDM-1 bacterial strains possess more potent hydrolysis ability towards almost all antibiotics, including Carbapenems. NDM-1 bacterial strains are sensitive to Tigecycline and Colistin but there is problem of side effects associated with them. In such a situation where NDM-1 strains are displacing antibiotic sensitive strains and are resistant to most of the chemotherapeutic agents, there is a need for the search of novel alternative effective therapeutic agents. The present bioprospective study aims to analyze the potential of various natural plants or their products, based upon bioactivity parameters and presence of chemical constituents, using matrix based modeling, followed by optimization. The outcomes of the lead identification need verification with respect to antimicrobial potential against virulent NDM-1 Escherichia coli.
FULL TEXT (PDF): 
PDF icon arastirmax-silico-modeling-identification-promising-antimicrobials-herbal-origin-against-highly-virulent-pathogenic-strains-bacteria-new-delhi-metallo-beta-lactamase-1-escherichia.pdf
  • 3
582
592
  • English

REFERENCES

References: 

[1] Kamboj V.P., “Herbal medicine,” Current Science, vol. 78, pp. 35-39, 2000.
[2] Weiss R.F., Fintelmann V., Herbal Medicine, 2nd English edition, New York: Thieme, 2000.
[3] Inamdar N., Edalat S., Kotwal V.B., Pawar S., “Herbal drugs in milieu of modern drugs,” International Journal of Green
Pharmacy, vol. 2, pp. 2-8, 2008.
[4] World Health Organization, WHO Global atlas of traditional, complementary and alternative medicine, Geneva, 2005.
[5] Raskin I., David M. Ribnicky, Komarnytsky S., Ilic N. et al., “Plants and human health in the twenty-first century,” TRENDS
in Biotechnology, vol. 20, no. 12, pp. 522-531, 2002.
[6] Navdeep S., Koyal S., Singh G.K., “Establishment of an Herbal Industry in India,” International Journal of Pharmaceutical
& Biological Archives, vol. 2, no. 4, pp.1011-1019, 2011.
[7] Agrawal O.P., Raju P.S., Abdin M.Z., Abroi Y.P., Global market of herbal products: Opportunities for India, Traditional
system of medicine, Narosa Publishing House: New Delhi, India; pp. 5-10, 2006.
[8] Giovanni B.O., Marco F., Mario V., “Surveillance and Management of Multidrug-resistant Microorganisms,” Expert Rev
Anti Infect Ther, vol. 9, no. 8, pp. 653-679, 2011.
[9] WHO Fact Sheet on Antimicrobial Resistance, 2012.
[10] CDC Fact Sheet, 2013.
[11] Shahcheraghi F., Nobari S., Rahmati Ghezelgeh F., Nasiri S., Owlia P., Nikbin V.S., Imani Fooladi A.A., “First report of New
Delhi metallo-beta-lactamase-1-producing Klebsiella pneumoniae in Iran,” Microb Drug Resist, vol. 9, no. 1, pp. 30-6,
2013.
[12] Chauhan A., “New Delhi Metallo-beta-lactamase: A misnomer?” International Journal of Clinical Cases and
Investigations, Vol. 1, no. 5, pp. 5-6, 2010.
[13] Schechner V., Kotlovsky T., Tarabeia J., et al., “Predictors of rectal carriage of carbapenem-resistant Enterobacteriaceae
(CRE) among patients with known CRE carriage at their next hospital encounter,” Infect Control Hosp Epidemiol, vol. 32,
no. 5, pp. 497-503, 2011.
[14] Mary J. A., Priyadharshini K.C., Amal G.P.R., et al., “MEDDB: A medicinal plant database developed with the information
gathered from tribal people in and around Madurai, Tamil Nadu,” Bioinformation, vol. 8, no. 8, pp. 391–393, 2012.
[15] Tao Qin, Tie-Yan Liu, Xu-Dong Zhang, Zheng Chen, Wei-Ying Ma, “A Study of Relevance Propagation for Web Search,”
International Conference on Research and Development in Information Retrieval (SIGIR), 2005.
[16] Baeza-Yates R., Ribeiro-Neto B., Modern Information Retrieval, Addison Wesley, 1999.
[17] Robertson S. E., and Sparck Jones K., “Relevance Weighting of Search Terms,” Journal of the American Society of
Information Science, vol. 27, no. May-June, pp. 129-146, 1976.
[18] Thakur P., Chawla R., Chowdhry A., Chakotiya A., Singh N., Goel R., Kaushik V., Arora R., Sharma R.K., “Targeting
Antibiotic Resistant Bacteria NDM-1 Escherichia coli adopting Ethnopharmacological Approach: An alternative strategy
to counteract superbugs menace,” Journal of Antimicrobials Photon, vol. 128, pp. 147-156, 2013.
[19] Beta-Lactamase Inhibitors, Department of Nursing of the Fort Hays State, University College of Health and Life Sciences,
October 2000.
[20] Beta-Lactamases in laboratory and clinical resistance, Clinical Microbiology Review.
[21] Ahmad I., Farrukh A. and Mohd. Owais, “Modern Phytomedicine: Turning Medicinal Plants into Drugs,” eds. 15, pp. 199-
226.
[22] Webber M.A., Piddock L.V.J., “The importance of efflux pumps in antibiotic resistance,” Journal of Antimicrobial
Chemotherapy, vol. 51, pp. 9-11, 2003.
[23] Li H.Z., Nikaido H., “Efflux-mediated drug resistance in bacteria,” Drugs, vol. 64, pp. 159-204, 2004.
[24] Piddock L.V., “Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria,” Clinical
Microbiology Review, vol. 19, pp. 382-402, 2006.
[25] Stermitz F.R, Beeson T.D., Mueller P.J., Hsiang J., Lewis K., “Staphylococcus aureus MDR efflux pump inhibitors from a
Berberis and a Mahonia (Sensu strictu) species,” Biochemical Systematics and Ecology, vol. 29, no. 8, pp. 793-798, 2001.
[26] Alviano D.S., Alviano C.S., “Plant extracts: search for new alternatives to treat microbial diseases,” Current
Pharmaceutical Biotechnology, vol. 10, no.1, pp. 106-21, 2009.
[27] Gibbons S., “Anti-staphylococcal plant natural products,” Nat. Prod. Rep., vol. 21, pp. 263-277, 2004.
In silico modeling for Identification of promising antimicrobials of Herbal origin against highly virulent pathogenic strains
of bacteria like New Delhi Metallo-beta-lactamase -1 Escherichia coli
ISSN : 2028-9324 Vol. 4 No. 3, Nov. 2013 592
[28] Gibbons S., Moser E., Kaatz G.W., “Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus,”
Planta Med., vol. 70, no. 12, pp. 1240-1242, 2004.
[29] Gibbons S., Oluwatuyi M., Veitch N.C., Gray A.I., “Bacterial resistance modifying agents from Lycopus europaeus,”
Phytochem., vol. 62, no. 1, pp. 83-87, 2003.
[30] Hemaiswarya S., Kruthiventi A.K., Doble M., “Synergism between natural products and antibiotics against infectious
diseases”, Phytomedicine, vol. 15, pp. 639–652, 2008.
[31] Clement Y.N., Morton-Gittens J., Basdeo L., Blades A., Francis M.J., Gomes N., Janjua M., Singh A., “Perceived efficacy of
herbal remedies by users accessing primary healthcare in Trinidad,” BMC Complementary and Alternative Medicine, vol.
7, pp. 7-4, 2007.
[32] Woo J. S., Ha B. H., Kim T. G., Lim Y., Kim K. H., “Inhibition of Helicobacter pylori adhesion by acidic polysaccharide
isolated from Artemisia capillaris,” J. Microbiol. Biotechnol., vol. 13, pp. 853-858, 2003.
[33] Diggle S., Crusz S., Cámara M., “Quorum sensing,” Current Biology, vol. 17, no. 21, 2007.
[34] Jakobsen T.H., Bragason S.K., Phipps R.K., Christensen L.D. et al., “Food as a source for QS inhibitors: Iberin from
Horseradish Revealed as a Quorum Sensing Inhibitor of Pseudomonas aeruginosa”, Department of International Health,
Immunology and Microbiology, University of Copenhagen, DK-2200 Copenhagen, Denmark.
[35] Smyth A.R., Cifelli P.M., Ortori C.A., Righetti K., Lewis S., Erskine P., Holland E.D., Givskov M., Williams P., Cámara M.,
Barrett D.A., Knox A., “Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot
randomized controlled trial”, Division of Child Health, University of Nottingham, Nottingham, UK.
[36] Choo J.H., Rukayadi Y., Hwang J.K., “Inhibition of bacterial quorum sensing by vanilla extract”, Department of
Biotechnology, Yonsei University, Seoul, Republic of Korea.
[37] Rasmussen T.B., Bjarnsholt T., Skindersoe ME.., Hentzer M., Kristoffersen P., Köte M., Nielsen J., Eberl L., Givskov M.,
“Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector”, Center for
Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
[38] Adonizio A.L., Downum K., Bennett B.C., Mathee K., “Anti-quorum sensing activity of medicinal plants in southern
Florida”, Department of Biological Sciences, Center for Ethnobiology and Natural Products, CENaP, Florida International
University, USA.
[39] Cheetham Alan H. and Hazel Joseph E., “Binary (Presence-Absence) Similarity Coefficients”, Journal of Paleontology, vol.
43, no. 5, pp. 1130-1136, 1969.
[40] Yager R., “On ordered weighted averaging aggregation operators in multi-criteria decision making, IEEE Transactions on
Systems,” Man, and Cybernetics, vol. 18, pp. 183-190, 1988.
[41] Meimandipour A., Hosseini Said A., Lotfolahian H., Hosseini Said J., Hosseini Said H., Sadeghipanah H., “Multiattribute
decision-making: use of scoring methods to compare the performance of laying hen fed with different levels of yeast”,
Italian Journal of Animal Science, vol. 11, no. 15, 2012.
[42] Triantaphyllou E., Shu B., Nieto Sanchez S., and Ray T., “Multi-Criteria Decision Making: An Operations Research
Approach”, Encyclopedia of Electrical and Electronics Engineering, vol. 15, pp. 175-186, 1998.
[43] Jenuwine Elizabeth S., “Comparison of Medical Subject Headings and text-word searches in MEDLINE to retrieve studies
on sleep in healthy individuals,” J Med Libr Assoc., vol. 92, no. 3, pp. 349–354, 2004.

Thank you for copying data from http://www.arastirmax.com