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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL AND INDAPAMIDE IN THEIR COMBINED TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The Present manuscript describes two simple, accurate, precise, economical, reproducible and specific spectrophotometric methods have been developed for simultaneous determination of Olmesartan Medoxomil (OLM) and Indapamide (IND) in its combined tablet dosage form by using methanol as a solvent. The first method is Q absorption method which involves Amax 241 nm (Amax of IND) and isoabsorptive point at 285.24 nm. The second method simultaneous method in which absorption at 286.78 nm (AMax of IND) was used for quantification of OLM and 256.40 nm (AMax of OLM) was used for quantification of IND. Two methods follow Beer's linearity in the range of 5-55 ug/ml and 1-25 ug/ml for OLM and IND both. The mean % recoveries were found to be in the range of 99.06 - 101.11 % and 98 -100.77 % for OLM and IND respectively for Q- absorption method and in the range of 99.72 - 102.88% and 98 - 101.58% OLM and IND respectively for simultaneous method. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of OLM and IND in their combined Tablet dosage form. The results of analysis have been validated statistically and also by recovery studies. Thus the present study gives an excellent method for the determination of all the two drugs in combined dosage formulation without their prior separation.
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  • 5
485-501
  • English

REFERENCES

References: 

1. Koike H, Sada T and Mizuno M: In vitro and in vivo pharmacology of olmesartan medoxomil, an angiotensin II type AT1 receptor antagonist". J Hypertens Suppl. 2001 June, http://www.drugbank.ca/drugs/DB00275
2. Dong DL, Wang QH, Yue P, Jiao JD, Gu RM and Yang BF: Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-
dependent K+ currents. Eur J Pharmacol. 2006 Apr, http://www.drugbank.ca/drugs/DB00808
3. The Merck Index - An encyclopedia of chemicals, drugs and biological, 14th Edn; Merck Research Laboratories, 2004: pp
1152, 86.
4. The Merck Index - An encyclopedia of chemicals, drugs and biological, 14th Edn;
Available Online At www.ijprbs.com
Research Article
Khushbu Patel, IJPRBS, 2012; Volume 1(5): 485-501
Merck Research Laboratories, 2004" pp
1152, 86.
5. British Pharmacopoeia, The department of health, The Stationery office, London,
2008; 1:137.
6. Olmesartan Medoxomil-wikipedia(http://en.wikipedia.org/wiki/Olm esartanMedoximil) accesed on 15 October,
2012
7. Indapamide-wikipedia ( http://en.wikipedia.org/wiki/Indapamide) accesed on 15th oct 2012
8. Jinay Shah, Parul Parmar and Mandev Patel: Development and Validation of Spectrophotometric methods for simultaneous estimation of Amlodipine Besylate and Indapamide in combined dosage form Int J Pharm Pharm Sci, Vol 4,
Issue 3, 257-261,2012
9. Mehulkumar P, Ramesh V, Vinay kumar V, Srinivas R and Diwan PV: Simultaneous Spectroscopic Estimation of Amlodipine Besylate and Olmesartan Medoximil in Tablet Dosage Form." Asian J. Res. Chem. 2009, 2, 127-130.
ISSN: 2277-8713 IJPRBS
10. Della Grace Thomas Parambi, Dr. Sr. Molly Mathew, Anila Jose and Dr. K G Revikuma: Estimation of Olmesartan Medoxomil, an angiotensin receptor blocker in pharmaceutical dosage form by U.V. Spectrophotometric method"J. Pharm. Res. 2010; 3: 1706-1708.
11. Rote AR and Bari PD: spectrophotometric estimation of Olmesartan Medoximil and hydrochlorothiazide in tablet". Indian J.
Pharm. Sci. 2010; 1: 111-113.
12. Jain Pritam, Chaube Udit, Chaudhari Rakesh, Chaudhari Khandu, Surana Sanjay and Chaudhari Amar: Development And Validation Of UV-Spectrophotometric Method For Determination Of Olmesartan Medoxomil In Bulk And In Formulation". Internationale Pharmaceutica Sciencia.2011; 3: 54-58.
13. Kardile D.P, Kalyane N.V., Thakkar T.H., Patel M.R. and Moradiya R.K: Simultaneous estimation of Amlodipine Besylate and Olmesartan Medoxomil drug formulations by HPLC and UV-spectrophotometric methods" J. Pharm. Research .2010; 9: 599¬614.
Available Online At www.ijprbs.com
Research Article
Khushbu Patel, IJPRBS,
2012; Volume 1(5): 485-501
ISSN: 2277-8713
IJPRBS
14. Peter E. Grebow, Jo A. Treitman, Anne K. Yeung and Martha M. Johnston: Semi automated assay for indapamide in biological fluids" J.Pharma.Sci. 70(3): 235¬350.
15. Ribeiro DS, Prior JA, Santos JL, Lopes JA and Lima JL: Exploiting the oxidative coupling reaction of MBTH for indapamide determination", Talanta. J.Pharma.Sci 2009:
161-168.
16. Nadia F. Youssef: spectrophotometric, Spectrofluorimetric, And Densitometric Methods for the Determination of Indapamide"Journal of Aoac International. 2003; 89(5): 935-940.
17. Guyton and Hall: Textbook of medical physiology; 11th Edn; Elsevier - Saunders Book Company, 2005: pp 147, 216.
18. Yokoyama H, Smith RD, Averill DB and Schiffrin E: Vascular improvement with olmesartan medoxomil. Am J Hypertens
2005; 18(5): 23.
19. Brousil JA and Burke JM: Olmesartan medoxomil: an angiotensin II receptorblocker. Clin Ther 2003; 25(4): 1041.
20. Jarvis B: Olmesartan medoxomil an angiotensin II receptor blocker. Drugs2002;
62(9): 1354.
21. Chrysaqnt
SG
, Weber MA, Wang ACand Hinman DJ: Evaluation ofantihypertensive therapy with thecombination of olmesartan medoxomil and hydrochlorothiazide, Am J
Hypertens 2004; 17(3): 252.
22. Greathouse M: A review of olmesartanmedoximil monotherapy: antihypertensive efficacy similar to that of other angiotensinII receptor blocker/hydrochlorothiazide combinations. Congest Heart Fail 2002; 8(6): 3
23. Schaefer M. Sankyo Res Lab and Benica TM: Determination of olmesartan medoxomil by diazotization reaction with fluorescent compound. Annual Rep 2003;
(55): 1-91.
24. Banerji P, "Symptoms of high blood pressure", 2009, http://www.tretmentfor. com/high blood pressure symptoms.htm
25. Kalpana N. Chauhan ,Jinay Shah and Parul Parmar: Development and Validation of Spectrophotometric methods for simultaneous estimation of Amlodipine Besylate and olmesartan medoximil in
Available Online At www.ijprbs.com
Research Article ISSN: 2277-8713
Khushbu Patel, IJPRBS, 2012; Volume 1(5): 485-501 IJPRBS
combined dosage form". Research Article Pharmacy and Pharmaceutical Sciences
accepted in International Journal of (IJPPS) vol 4 suppl4/4432.pdf
Available Online

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