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AYDINLIK: KARANLIK DÖNGÜSÜNÜN MODÜLASYONUNUN PORSOLT YÜZME TESTİNDEKİ ANTİDEPRESAN ETKİLERİNİN ZAMANSAL SINIRLARI

Temporal limitations of the antidepressant-like effects of modulating light-dark cycle on Porsolt Swimming Test

Journal Name:

  • İstanbul Üniversitesi Psikoloji Çalışmaları Dergisi

Publication Year:

  • 2005
Author NameUniversity of Author
Abstract (2. Language): 
This study aimed to determine temporal extent of the antidepressant-like effect of modulating Light:Dark cycle in Light:Light direction for one session. Fifty-six female Wistar rats were randomly allocated either to one of 3 experimental or 4 control groups, which underwent to Porsolt Swimming Test sessions separated by 24 hours, after 24,96 or 168 hours following the offset of manipulation. Animals in the fourth control group, called as the no treatment group, were kept in vivarium and underwent only the PST trials without any manipulation. Antidepressant-like protective effects of light were observed to extend to 168 hours.
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Abstract (Original Language): 
Bit çalışma kapsamındaki iki deneyde 24 saatlik aydmhk-karanlık döngüsünü aydınhk-aydınUk döngüsünü değiştirmenin antidepresan etkinliği incelenmiştir. Aydınlık-karanlık döngüsünün karanlık fazında bir gecelik olarak verilen 12 saatlik ışık pulsünün dişi Wistar sıçanların 24 saat aralıkla uygulanan yüzme lestindeki (PST) performansı üzerine etkinliği ve bu etkinliğin zamansal sınırları araştırılmıştır. Bu deneyde 3 adet deney grubu, bu deney gruplarının herbirinin kendi kontrol grubu ve bir adet de herhangi bir manipulasyona maruz kalmamış olan temel kontrol grubu olmak üzere 7 gruba random olarak dağıtılmış olan 56 adet dişi Wistar sıçan kullanılmıştır. Deneysel manipıılasyonun sona ermesinden, bağlı bulundukları gruba göre, 24, 96 ya da 168 saat sonra yüzme testine tabi tutulmuşlardır. İstatistik analizler ışığın koruyucu antidepresan etkinliğinin ışık pulsünün sona ermesinden 168 saat sonra bile etkili olduğunu göstermiştir.
FULL TEXT (PDF): 
PDF icon arastirmax-aydinlik-karanlik-dongusunun-modulasyonunun-porsolt-yuzme-testindeki-antidepresan-etkilerinin-zamansal-sinirlari.pdf
  • 1
31-48
  • Turkish

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