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Astımlı Hastalarda Tüberkülin Testinin Duyarlılığı

Tuberculin Skin Test Sensivity in Asthma Patients

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
The aim of this study was to evaluate the tuberculin reaction which develops with Th 1 type immune reaction in asthma in which Th2 type immune reaction is dominant. This study included 36 cases with allergic asthma, 64 cases with non allergic asthma and 51 cases without asthma. Tuberculin skin test was applied with Monteux method to all cases and induration diameter developed after 72 hours was recorded as millimeter. Tuberculin positivity was significantly different between cases with asthma and cases without asthma (p<0.05). The tuberculin induration diameter was calculated as 10.9±9.04 mm in cases with asthma and 15.3±5.95 mm in cases without asthma. The difference between them was significant (p<0.05). There was no significant relationship between tuberculin induration diameter and BCG scar (p>0.05). With respect to tuberculin positivity, significant difference was not present between asthma cases that are allergic and non allergic (p>0.05). While the tuberculin skin test results are evaluated presence of allergic diseases should be taken into consideration.
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Abstract (Original Language): 
Bu çalışmanın amacı Th2 tip Immun yanıtın baskın olduğu astımda Th1 tip immun yanıt ile oluşan tüberkülin reaksiyonunu incelemektir. Bu çalışma astımı alerjik olan 36, astımı alerjik olmayan 64 ve astımı olmayan 51 olguyu kapsamaktadır. Olguların hepsine tüberkülin deri testi Mantoux yöntemiyle uygulandı ve 72 saat sonra oluşan endürasyon çapı mm olarak kaydedildi. Tüberkülin pozitifliği astımlı olan ve olmayanlarda anlamlı olarak farklıydı (p<0.05).Astımı olanlarda tüberkülin endurasyon çapı 10.9±9.04 mm ,astımı olmayanlarda 15.3±5.95 mm olarak ölçüldü. Aradaki fark anlamlıydı(p<0.05). Tüberkülin endurasyon çapı ile BCG skarı arasında anlamlı ilişki yoktu(p>0.05).Astımı alerjik olan ve olmayanlar arasında tüberkülin pozitifliği arasında anlamlı fark yoktu(p>0.05). Tüberkülin sonuçları değerlendirilirken alerjik hastalıkların varlığı da dikkate alınmalıdır.
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  • 3
157-159
  • Turkish

REFERENCES

References: 

1. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-46.
2. Prescott S, Macaubas C, Smallacombe T, et al. Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999;353:196-200
3. Woolcock AJ, Peat JK. Evidence for the increase in asthma worldwide. In: Ciba Foundation Editor. The Rising Trends in Asthma. John Wiley & Sons, Chiester 1997;122-39.
4. Von Hertzen LC. The hygiene hypothesis in the development of atopy and asthma-still a matter of controversy? Q J Med 1998;91:767-71.
5. Shirakawa T, Enomoto T, Shimazu S-1, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997;275:77-9.
6. Wang EC, Rook GAW. Inhibition of established allergic response to ovalbumin in Balb/c mice by killed Mycobacterium vaccae. Immunology 1998;93:307-13.
7. Shaheen SO,Aaby P, Hall AJ. Measles and atopy in Guinea-Bissau. Lancet 1996;347:1792-6.
8. Strannegard IL, Larsson LO, Wennergren G. Prevalence of allergy in children in relation to prior BCG vaccination and infection with atypical mycobacteria. Allergy 1998;53:249-54.
9. Alm J, Lilja G, Pershagen G. Early BCG vaccination and development of atopy. Lancet 1997;350:400-3.
10. Yılmaz M, Bingöl G, Altıntaş D, Kendirli SG. Correlation between atopic diseases and tuberculin responses. Allergy 2000;55:664-7.
11. Nuhoğlu Y, Nuhoğlu C, Özçay S. The associaiton between delayed type hypersensitivity reaction, Mycobacterium tuberculosis and atopy in asthmatic children. Allergol Immunopathol 2003;31:14-7.

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