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Organofosfat insektisit Fenthion'un rat amila z ve lipaz enzimleri üzerine etkisi: Vitamin E ve C'nin rolü

The effects of organophosphate insecticide Fenthion on rat amylase and lipase enzymes: Role of vitamins E and C

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Organophosphates cause toxic effects via inhibition of the enzyme, cholinesterase. In some poisonings, they cause acute pancreatitis. Therefore we aimed to investigate organophosphate insecticide Fenthion's adverse effects on rat pancreas and whether Vitamins C and E have protective role on possible adverse effects of Fenthion. Study groups were designed as control group, Fenthion treated (administered % 25 of LD50) group and Fenthion+Vitamins C and E treated group. The blood samples were obtained 24 hours after Fenthion treat¬ment. The activities of serum enzymes were determined in each sample at 24 h. When compared with control group lipase activity was significantly decreased in Fenthion treated group. When compared with Fenthion treated group lipase activity was significantly increased in Fenthion+Vitamins E and C treated group. In conclusion from this findings, it is thought that Fenthion causes pancreas damage when administered at these doses to rats ,and that this may be prevented by Vitamins E and C treatment. Probably antioxidant mechanism mediates the preventive effect of Vitamins E and C .
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Abstract (Original Language): 
Organofosfatlar kolinesteraz enzimini inhibe ederek toksik etkilere neden olmaktadır. Bazı zehirlenmelerde de akut pankreatite neden olmaktadırlar. Biz de, ratlarda; organofosfat insektisit Fenthion'un pankreas üzerine zararlı etkilerini ve Fenthion'un olası zararlı etkilerinin Vitamin E ve C kombinasyonunu ile önlenip önlenemeyeceğini araştırmayı amaçladık. Çalışma grupları; kontrol grubu, Fenthion verilen (IXfeo'nin % 25'i) grup ve Fenthion+Vitamin E ve C verilen grup şeklinde düzenlendi. Fenthion uygulamasından 24 saat sonra kan örnekleri alındı ve serumda amilaz ve lipaz aktiviteleri ölçüldü. Kontrol grubuyla karşılaştırıldığında Fenthion uygulanan grubun lipaz aktivitesinin anlamlı olarak azaldığı görüldü. Fenthion uygulanan grup ile Fenthion+Vitamin E ve C verilen grup karşılaştırıldığında ise lipaz aktivitesinin anlamlı olarak arttığı görüldü. Sonuç olarak bu bulgulardan Fenthion'un bu dozda ratlara uygulandığında pankreas hasarına neden olduğu ve bunun da Vitamin E ve C uygulaması ile önlenebileceği düşünüldü. Olasılıkla Vitamin E ve C'nin önleyici etkisini antioksidan mekanizma ile yaptığı düşünülmektedir.
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  • 2
21-23
  • Turkish

REFERENCES

References: 

1. Kalkan S, Erdogan A, Aygoren O, Capar S, Tuncok Y. Pesticide poisonings reported to the drug and poison information center in Izmir, Turkey. Vet Hum Toxicol. 2003;45:50-52.
2. Sahin I, Onbasi K, Sahin H, Karakaya C, Ustun Y, Noyan T. The prevelance of pancreatitis in organophos-phate poisonings. Hum Exp Toxicol. 2002;21:175-177.
3. Carr RL, Richardson JR, Guarisco JA, Kachroo A, Chambers JE, Couch TA, Durunna GC, and Meek EC. Effects of PBC exposure on the toxic impact of organophosphors insecticides. Toxicological Sciences 2002;67:311-321.
4. Karalliadde L. Organophosphorus poisoning and anes¬thesia. Anesthesia 1999;54:1073-1088.
5. Zendzian RP. Pesticide residue on/in the Washed skin and its potential contribution to dermal toxicity. J Appl Toxicol. 2003;23:121-136.
6. Dabrowski S, Hanke W, Polanska K, Makowiec-Dabrowska T, Sobala W. Pesticide exposure and birth-weight: an epidemiological study in Central Poland. Int J Occup Med Environ Health 2003;16:31-39.
7. Lotti M. Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors. Toxicology 2002;27:181-182:245-248.
8. Karalliadde L, Senanayake N. Organophosphorus insecticide
poisoning. Journal of the International Federation of Clinical Chemistry 1999;11:1-9.
9. Garry B, Casida JE. Sensitivity of blood-clotting factors and digestive enzymes to inhibition by organophosphores pesticides. J Biochem Molecular Toxicology. 2000;14:51-56.
10. Altuntaş İ, Delibaş N. The effects of Fenthion on lipid peroxidation and some liver enzymes: The possible protec¬tive role Vitamins E and C. Turk J Med Sci. 2002;32:293-
297.
11. Bagchi D, Bagchi M, Hassoun EA, Stohs SJ. In vitro and in vivo generation of reactive oxygen species. DNA damage and lactate dehydrogenase leakage by selected pes¬ticides. Toxicology 1995;104:129-140.
12. Gültekin F, Delibaş N, Yaşar S, Kılınç İ. In vivo changes in antioxidant systems and protective role of mela-tonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Archives Toxicology 2001;75:88-96.
13. Appenroth D, Frög S, Kersten L, Splinter FK. Protective effects of vitamin E and C on Cisplatin nephro-toxicity in developing rats. Archives Toxicology 1997;71:677-683.
14. Kan PK, Sinha SP. Vitamin C mediated amelioration of pesticide genotoxicity in murine spermatocytes. Cytobios 1994;80:199-204.
15. Kan PK, Sinha SP. Antimutagenic efficacy of higher doses of vitamin C. Mutat Res 1993;298:157-161.
16. Martin Rubi JC, Yelamos Rodriguez F, Laynez Bretones F, Cordoba Escamez J, Diez Garcia F, Lardelli Claret A, Blanco Corodona JL et al. Poisoning caused by organophosphate insecticides. Study of 506 cases. Rev Clin Esp. 1996;196:145-149.
17. Hsiao CT, Yang CC, Deng JF, Bullard MJ, Liaw SJ.
Acute pancreatitis following orgaphosphate intoxication. J
Toxicol Clin Toxicol. 1996;34:343-347.
18. Liu S, Oguchi Y, Borner JW, Runge W, Dressel TD,
Goodale RL. Increased canine pancreatic acinar cell dam¬age after organophosphate and acetylcholine or cholecys-tokinin. Pancreas 1990;5(2):177-182.
19. Panieri E, Krige JE, Bornman PC, Linton DM. Severe necrotizing pancreatitis caused by organophosphate poi¬soning. J Clin Gastroenterol. 1997;25:463-465.
20. Costa LG, Cole TB, Furlong CE. Polymorphisms of paraoxonase (PON1) and their significance in clinical tox¬icology of organophosphates. J Toxicol Clin Toxicol. 2003;41(1):37-45.
21. Rodriguez MM, Bisset J, Ruiz M, Soca A. Cross-resist¬ance to pyrethroid and organophosphorus insecticides induced by selection with temephos in Aedes aegypti (Diptera: Culicidae) from Cuba. J Med Entomol.
2002;39:882-888.

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