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ÎDRAR YOLLARI EPÎTELÎ, RENAL TÜBÜL EPÎTELÎ KADAR YETENEKLİ MÎDÎR ?

IS THE URINARY TRACT EPITHELIUM TALENTED AS THE RENAL TUBULAR EPITHELIUM ?

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The urothelium serves as a barrier and a storage functions due to the specialized structure of the superficial cells and junctional complexes, while maintaining the urine composition similar to that generated by kidneys. The apical membrane of the urothelium has an asymmetric unit membrane (A UM) structure. Uroplakins (UPs), constituting the A UM, are the first specific urothelial differentiation markers described. Apical membranes also posses sodium channels along with other ion transport systems, that regulate transcellular ionic flux. The urothelium can also function as a secretor of urinary proteins and human growth hormone. UPs have the potential role for pathogenesis of primary vesicoureteral reflux and Echerichia coli infection. UPs are sensitive and specific markers for a tumor of urothelial origin. The urothelium can modify the urinary contents by reabsorbing or secreting specific solutes, and has an important functions similar that the renal tubular epithelium.
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Abstract (Original Language): 
Üroteliyum, yüzey hücrelerinin özelleşmiş yapısı ve bağlantı kompleksleri sayesinde, böbrekler tarafından üretilmiş idrarın içeriğini değiştirmeksizin, bariyer ve depolama fonksiyonları görür. Üroteliyum apikal membranı asimetrik birim membran (ABM) yapısı gösterir. ABM' ı oluşturan üroplakinler (UP' ler), üroteliyal farklılaşmanın tanımlanmış ilk özgül belirleyicileridir. Apikal membranlarda diğer iyon transport sistemlerinin yanı sıra sodyum kanalları da bulunur, bunlar hücre boyunca iyon geçişini kontrol ederler. Üroteliyumun idrar proteinleri ve insan büyüme hormonu salgılayıcıfonksiyonları da vardır. UP' lerin primer vezikoüreteral reflü ve Echerichia coli infeksiyonupatogenezinde potansiyel rolleri vardır. UP' ler üroteliyal tümörler için özgül ve duyarlı belirleyicilerdir. Üroteliyum özgül maddelerin emilimi veya salgılanması ile idrar içeriğini değiştirebilmektedir, diğer bir deyişle renal tübül epiteline benzer önemli fonksiyonları vardır.
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  • 2
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  • Turkish

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