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EPATİT B VİRÜSÜ İLE İLİŞKİLİ DİFFÜZ PROLİFERATİF GLOMERÜLONEFRİTİN OLUŞTURDUĞU NEFROTİK SENDROM VE CİDDİ BÖBREK YETMEZLİĞİNİN İMMÜNSUPRESİF İLAÇLARLA BAŞARILI TEDAVİSİ

SUCCESSFUL TREATMENT OF NEPHROTIC SYNDROME AND SEVERE RENAL FAILURE DUE TO HEPATITIS B VIRUS RELATED DIFFUSE PROLIFERATIVE GLOMERULONEPHRITIS, WITH IMMUNSUPPRESSIVE DRUGS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Chronic hepatitis B virus (HBV) associated glomerular disease are mainly membranous glomerulonephritis, m embranoproliferative glomerulonephritis, essential mixed cryoglobulinemia, IgA nephropathy and diffuse proliferative glomerulonephritis. The pathogenesis of HBV related GN has been defined as chronic antigenemia and passive deposition of immune complex in glomeruli. We reported here a patient with liver cirrosis and proliferative GN related with HBV. A fortyl-one year old man, with history of hepatitis a 20 years ago was admitted to hospital due to generalized edema. Physical examination showed that ascites, pretibial edema and diminished pulmonary sounds. Laboratory investigations were as follows: BUN 86 mg/dl, creatinin 2.2 mg/dl, total protein 5 g/dl, serum albumin 2.3 g/dl, daily proteinuria 4g. and HbsAg positive. Liver and renal biopsy showed that chirrosis, and diffuse proliferative glomerulonephritis. In this patient, nephrotic syndrome and dialysis requiring acute renal failure regressed with corticosteroid and cyclophosphamide treatment. In follow-up period after 12 months, his renal function was within normal limits and proteinuria was negative.
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Abstract (Original Language): 
Kronik hepatit B virus(HBV) enfeksiyonu ile ilişkili glomerular hastalıklar arasında ınembranoz glome rulonefrit (GN), membranoproliferatif GN, esansiyel mixt kryoglobulinemi, IgA nefropatisi ve diffüzproliferatif GN sayılmaktadır.HBV ilişkili glomurulonefritlerin patogenezinde, kronik antijenemi ve glomerulde immün komplexlerin pasif birikimi suçlanmaktadır. Burada HBV ilişkili karaciğer sirozu ve diffüzproliferatif glomerulonefriti olan bir olgu sunulmuştur. Yirmi yıl önce sarılık hikayesi olan 41 yaşında erkek hasta ödem nedeni ile kabul edildi. Fizik incelemede asit, pretibial ödem ve akciğer seslerinde azalma saptandı Laboratuar incelemede; BUN 86 mg/ di, kreatinin 2.2 mg/dl, total protein 5 g/dl, serum albumin 2.3 mg/dl, günlük proteinüri 4 g idi. HbsAg pozitif olarak bulundu.Karaciğer ve böbrek biyopsisinde, siroz ve diffüzproliferatif glomerulonefrit saptandı. Bu hastada, nefrotik sendrom ve diyaliz gerektiren akut böbrek yetersizliği kortikosteroid ve siklofosfamid tedavisi ile geriledi.Oniki aylık takibinde böbrek fonksiyonları normaldi ve proteinürisi negatifti.
FULL TEXT (PDF): 
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  • 3
181-183
  • Turkish

REFERENCES

References: 

1. Willson RA. intrahepatic manifestations of chronic viral hepatitis. AJG 1997; 92: 4-15.
2. Johnson RJ, Feehally J. Introduction to glomerular disease: Pathogenesis and classification. In: Johnson RJ, Feehally J (eds), Comphrensive clinical nephrology, i"1 Ed. MOSBY Barcelona 2000, pp 20.
3. Johnson RJ, Burdmann EA, Ophascharoensuk V et al. Glomerular disease associated with infection. Johnson RJ, Feehally J (eds), Comprehensive clinical nephrology. Ith Ed. MOSBY Barcelona
2000, pp 30.
4. Lin CY. Treatment of hepatitis B virus-associated membranous nephropathy with recombinant alpha-
interferon. Kidney Int 1995; 47: 225-230.
5. Endo M, Ohi H, Fujita T et al. Appearance of nephrotic syndrome following interferon-alpha therapy in a patient with hepatitis B virus and hepatitis C virus co infection. Am J Nephrol 1998; 18:439-43.
6. Wong SN, Yu EC, Chan KW. Hepatitis B virus associated membranous glomerulonephritis in children-experience in Hong Kong. Clin Nephrol
1993; 40: 142-7.
7. Kurihara I, Saito T, Kakayama K et al. A case of hepatitis C virus associated membranous glomerulonephritis ameliorated by corticosteroid
therapy. Nippon Jinzo Gakkai Shi 1998; 40: 290-4.

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