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Renal Transplant Alıcılarında Serum CRP, SAA ve C5a Düzeylerinin Akut Rejeksiyonun Erken Tanı ve Takibindeki Önemi

Significance of Serum CRP, SAA and C5a Levels in the Diagnosis and Management of Acute Renal Allograft Rejection

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2005

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Interpretation of the significance of SAA, CRP and C5a levels in the early diagnosis and follow-up of acute rejection has been aimed. Thirty-nine patients who underwent renal transplantation at the Çukurova University Transplantation Unit between November 2001 and January 2004 were included in the study. The levels of SAA, CPR and C5a were measured before transplantation and du¬ ring two weeks after transplantation. In 6 of the 39 patients who underwent renal transplantation acute rejection occured. The outcomes indicated that serum SAA and CRP levels increased 1-2 days prior to acute rejection (p<0.001). It can be concluded that the use of serial measurements of serum SAA and CRP levels is a valuable and easy method in the early diagnosis and management of acute allograft rejection.
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Abstract (Original Language): 
Renal transplant alıcılarında serum CRP, SAA ve C5a ölçümlerinin akut rejeksiyonun erken teşhis ve takibindeki önemi araştırıldı. Çukurova Üniversitesi Organ Nakli Merkezi'nde, Kasım 2001 ve Ocak 2004 arasında renal transplantasyon yapılan 39 alıcı çalışma grubu, 25 sağlıklı kişi kontrol grubu olarak çalışmaya alındı. Transplant alıcıların SAA, CRP ve C5a düzeyleri transplant öncesi ve transplant sonrası dönemde iki hafta süresince ölçüldü. Otuz dokuz alıcının 6'sında akut allogreft rejeksiyonu gelişti. Rejeksiyon gelişen alıcılarda, SAA ve CRP düzeylerinin, rejeksiyondan 1-2 gün önce yükseldiği ve bunun anlamlı olduğu (p<0.001), C5a değerlerininde ise fark olmadığı saptandı (p>0.05). Renal transplantasyon sonrası, serum CRP ve SAA düzeyleri¬ nin ölçümlerinin, akut rejeksiyon gelişen hastaların erken tanısı ve takibinde rahatlıkla kullanılabilecek, değerli, risksiz ve uygulanması kolay bir yöntem olduğu gürüşündeyiz.
FULL TEXT (PDF): 
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  • 4
171-176
  • Turkish

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