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İmmünsupresif Tedavi Altındaki bir Myastenia Gravis Hastasında Nefrotik Sendrom

Nephrotic Syndrome in a Patient with Myastenia Gravis Under Immunosupressive Therapy

Journal Name:

Publication Year:

DOI: 
10.5262/tndt.2011.1003.19

Keywords (Original Language):

Abstract (2. Language): 
Thymoma and myasthenia gravis are frequently associated, However, the nephrotic syndrome has been observed rarely in association with a thymoma. We report a 56-year-old patient with a history of thymectomy 3 years ago and myasthenia gravis who developed nephrotic syndrome under immunosupressive treatment. The pathogenesis is not clear and the role of a disorder of T-cell function and of circulating cytokines is discussed.
Abstract (Original Language): 
Timoma ve Miyastenia Gravis sıklıkla beraber görülebilse de timoma ile nefrotik sendrom birlikteliği nadirdir. Biz burada; Miyastenia Gravisli ve timektomi öyküsü olan 56 yaşındaki bir olguda, immunsupresif tedavi almakta iken 3 yıl sonra gelişen nefrotik sendrom olgusunu sunuyoruz. Patogenezi net bilinmemekle beraber T hücre fonksiyon bozukluğu ve sitokinlerin sorumlu olabileceği düşünülmektedir.
307-309

REFERENCES

References: 

1. Carr AS, Cardwell CR, McCarron PO, McConville J: A systematic
review of population based epidemiological studies in Myasthenia
Gravis. BMC Neurol 2010; 18: 10-46
2. Fleury MC, Tranchant C: Myasthenia gravis. Rev Prat 2008; 58:
2217-2224
3. Sanders DB, Evoli A: Immunosuppressive therapies in myasthenia
gravis. Autoimmunity 2010; 43: 428-435
4. Tormoehlen LM, Pascuzzi RM: Thymoma, myasthenia gravis, and
other paraneoplastic syndromes. Hematol Oncol Clin North Am
2008; 22: 509-526
5. Sun XG, Wang YL, Liu YH, Zhang N, Yin XL, Zhang WJ:
Myasthenia gravis appearing after thymectomy. J Clin Neurosci
2011; 18: 57-60
309
Sipahi S ve ark : İmmünsupresif Tedavi Altındaki bir
Myastenia Gravis Hastasında Nefrotik Sendrom
Türk Nefroloji Diyaliz ve Transplantasyon Dergisi
Turkish Nephrology, Dialysis and Transplantation Journal
Turk Neph Dial Transpl 2011; 20 (3): 307-309
6. Elkiran ET, Abali H, Aksoy S, Altundag K, Erman M, Kars A,
Turker A, Tekuzman G, Ozisik Y: Thymic epithelial neoplasia: A
study of 58 cases. Med Oncol 2007; 24: 197-201
7. Briani C, Cagnin A, Blandamura S, Altavilla G: Multiple
paraneoplastic diseases occurring in the same patient after
thymomectomy. J Neurooncol 2010; 99: 287-288
8. Posner MR, Prout MN, Berk S: Thymoma and the nephrotic
syndrome: A report of a case. Cancer 1980; 45: 387-391
9. Renaudineau E, Lobbedez T, Reman O, el Haggan W, Ryckelynck
JP, Hurault de Ligny B: Glomerulonephritis revealing a thymus
tumor in a patient with myasthenia gravis. Rev Med Interne 2001;
22(8): 763-764
10. Zbiti N, Ouadnouni Y, Arrayhani M, Houssaini TS, Rhou H,
Benamar L, Ouzeddoun N, Zaitouni F, Alhamany Z, Benosman A,
Bayahia R: Glomerulonephritis and thymoma: A case report and
review of the literature. Rev Pneumol Clin 2009; 65(5): 322-324
11. Mitsui T, Okada K, Kuhara T, Hashizume T, Okazaki S, Kawajiri
M, Matsumoto T: Mesangial proliferative glomerulonephritis with
deposits of anti-nicotinic acetylcholine receptor antibody in a
patient with myasthenia gravis. J Clin Neurosci 2001; 8: 454-456
12. Prasad KP, Alahakoon DG, Vidanagama U: Case of generalised
myasthenia gravis with membranous nephropathy. Ceylon Med J
2008; 53: 25-26
13. Karras A, de Montpreville V, Fakhouri F, Grünfeld JP, Lesavre P;
Groupe d’Etudes des Néphropathies Associées aux Thymomes:
Renal and thymic pathology in thymoma-associated nephropathy:
Report of 21 cases and review of the literature. Nephrol Dial
Transplant 2005; 20: 1075-1082
14. Valli G, Fogazzi GB, Cappellari A, Rivolta E: Glomerulonephritis
associated with myasthenia gravis. Am J Kidney Dis 1998; 31:
350-355
15. Tomida C, Yamagata K, Ishizu T, Nakajima M, Doi M, Kobayashi
M, Koyama A: A case of nephrotic syndrome associated with
myasthenia gravis and malignant thymoma. Nippon Jinzo Gakkai
Shi 1999; 41: 77-82
16. Jayasena SD, Woolfson RG, Griffi ths MH, Neild GH: Nephrotic
syndrome, malignant thymoma, and myasthenia gravis. Case report
and review of the literature. Am J Nephrol 1995; 15: 361-363

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