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HEMODÎALÎZ VE ADPD TEDAVİSİ ALTINDAKİ HASTALARDA RENAL OSTEODİSTROFİ'NİN DEĞERLENDİRİLMESİ

EVALUATION OF RENAL OSTEODISTROPHY IN PATIENTS UNDERGOING HEMODIALYSIS VS CONTINUOUS AMBULATORY PERITONEAL DIALYSIS

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Abstract (2. Language): 
We performed this study in order to find the frequ¬ency and severity of renal osteodystrophy (ROD) in our patients with chronic renal failure who were eit¬her on hemodialysis or continuous ambulatory perito¬neal dialysis (CAPD) programs. We compared these two groups of patients in respect of ROD and divalent ion metabolism, to see whether there was any diffe¬rence which might be due to different dialysis met¬hods. 30 patients who were being followed by Ege University Dialysis unit were admitted to this study. 15 of the patients were receiving hemodialysis while the other half were on CAPD treatment. Divalent ion metabolism, and immunoreactive parathormone (iPT/1) levels were investigated in both groups. In ad¬dition, X-ray lesion, bone scans, and bone histology Were studied. In both hemodialysis and CAPD gro¬ups, mild ROD detected, but severity and bone frequ¬ency of ROD was not statistically different in either group.
Abstract (Original Language): 
Kronik böbrek yetmezliği olan, ayaktan devamlı periton diyalizi (ADPD) ve hemodiyaliz programındaki hastalarımıza renal Osteodistrofi (ROD) yaygınlığını ve derecesini değerlendirmek, her iki grup ara¬sında divalen iyon metabolizması ve ROD açısından bir farklılık olup olmadığını ortaya koymak amacıyla bu çalışmayı yaptık. Ege Üniversitesi diyaliz ünitesinde takip edilen, hemodiyaliz programından 15 has¬ta ve ADPD programından 15 hasta olmak üzere top¬lam 30 hasta çalışmaya alınmıştır. Değerlendirme biyokimyasal, radyolojik, sintigrafik ve histolojik ola¬rak yapıldı. Her iki çalışma grubumuzda divalen iyon metabolizması, vitamin D metabolizması, PTH ilişki-sindeki bozukluk, değerlendirmeye alınanparametre-lerde çeşitli derecelerde kendini göstermiştir. ADPD ve hemodiyaliz programında olan hastalarımızda ROD bulguları hafif düzeylerde bulundu. Gruplar arasında ROD yaygınlığı ve derecesi açısından fark¬lılık saptanmadı.
FULL TEXT (PDF): 
60-63

REFERENCES

References: 

1. Cobum JW, Slatopolsky E: Vitamin D, parathyroid hormone and renal ostedystrophics, in The Kidney, edited by Brenner B, Rector F, Philadelphia, W.B. Sounders, 1991, pp. 2036-2120
2. Cobum JW, Llach F: Renal osteodystrophy and mainte¬nance dialysis, in Replacement of renal function by di¬alysis, edited by Drukker W, Parsons FM and Maher JF, 1986, pp. 679-711
3. Cundy TF, Canis JA: Renas Bone Disease. Br Med J 1985; 35-40.
4. Mankin HJ: Rickets, Osteomalacia, and renal Osteodys-trophy. Orthop Clin North Am 1990; 21: 81-93
5. Mazzaferro S, Coen G et al: Osteocalcin, iPTH, Alkaline Phosphatase and Hand X-Ray Scores as Predictive Indi¬ces of Histomorphometric Parameters in Renal Osteodys-
trophy. Nephron 1990; 56: 261-266.
6. Meema HE, Rabinovich S et al: Improved Radiological Diagnosis of Azotemic Osteodystrophy. Radiology 1972;
102: 1-10.
7. Debnam JW, Bates ML et al: Radyological/Pathological Correlations in Uremic Bone Disease. Radiology 1977:
125: 653-658.
8. Delmez JA, Fallon MD et al: Continious Ambulatory pe-ritonal Dialysis and bone. Kidney Int 1986; 30: 379-384.
9. Karsenti G, Vigneron Net al: Value of 99 mTc-methlyle-
62
ne
diphosphonat
e bone scan in renal osteodist rophy. Kidney Int 1986; 29:1058-1065. •
10. Ellis HA, Peart KM: Azotaemic renal osteodystrophy: a quantitative study on iliac bone. J Clin Path 1973; 26:
83-101.
11. Sherrard DJ, Hercz G et al:The spectrum of bone disease inend-stage renal failure An evolving disorder. Kidney Int 1993; 43: 436-442.
12. Shusterman NH, Wasserstein AG et al: Controlled Study of Renal Osteodistrophy in Patients Undergoing Dialysis: Improved Response to Continuous Ambulatory Peritone¬al Dialysis Compared with Hemodialysis. Am J Med 1987; 82: 1148-1156.
13. Cassıdy MJ, Owen JP et al: Renal osteodystrophy and Metastatic Calcification in Long-term Continuous Am¬bulatory Peritoneal Dialysis. Q J Med 1985; 213: 29-48.
14. Maıorca R, Cacarini C et al: Morbidite and mortality dl
CAPD and Hemodialysis. Kidney Int 1993 43
(Suppl.40): S4-S15.
15. Maiorca R. Cacarini C et al: Is CAPD Competitive with Hemodialysis for Long-term Treatment of Uraemic Pati¬ents. Nephrol Dial Transplant 1989; 4: 244-253.
16. Cobum JW: Mineral Metabolizm and renal bone disease: Effects of CAPD versus Hemodialysis. Kidney Int 1993;
43 (Suppl. 40): S92-S100.
17. Churchill DN: Comparative morbidity amog hemodialy-sis and continuous ambulatory peritoneal dialysis pati¬ents. Kidney Int 1993; 43 (Suppl. 40): S16-S22.
18. Delmez JA, Slatopolsky E et al: Minerals, vitamin D, and paratiroid hormone in continuous ambulatory peritoneal dialysis. Kidney Int 1982; 21: 862-867.
19. Malluche H, Ritz E et al: Bone histology in incipient and advanced renal failure. Kidney Int 1976; 9: 355-362.
20. Cobum JW: Renal osteodystrophy. Kidney Int 1980; 17:
677-693.

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