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AEROBİK VE AN AEROBİK AKUT EGZERSİZLERİN İMMUN PARAMETRELER ÜZERİNDEKİ ETKİLERİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The effect of aerobic and anaerobic acul exercises on the immune paramaters. Exercise is the hig-hest stress on the body. The body respons this stress by several physiological changes on metabolic, hormonal and immunological systems. In this study imınunological responses to acute aerobic and anaerobic exercises were examined. 24 sedantary male university staff and student were chosen for this study. Volunteers were separated into two groups as aerobic and anaerobic. Physical examinations, resting EKG's, pulmonary function tests, metabolic conditions tests by breath by breath method with Bruce protocol svere done both two groups. After their anaerobic thresholds were determined, Monark cycle ergometer exercise were carried ffırough, under threshold level of heart rate for aerobic group (Max VO2 %50, 30 min.) and above threshold level of heart rate for anaerobic group (Max VO2 %75, 20 min.). During the exercise heart rates of volunteers were controlled by Polar Tester. Peripheral venous blood samples vvere taken before exercise (ER), after 1 min. of exercise (Eı-min.) and after 45 min. of exercise (E45.mi„.) from both two groups. Hb (gr), Hct (%) erytrocyte (xl07mrn3), leucocyte (x lfr/mm3) and % neutrophile, % lmphocyte, % ırıonocyte, % eozinephyl, % basophyl and trombocyte (x lCP/mm3) values were determined by Technican H-2 System. CD3, CD4, CD8, CD19 and CD56 levels were found by flow Cytometry. The acute effect of exerci-se were investigated in the blood samples. The effect of exercise to number of leucocyte, subsets group of leucocyte and lymphocyte were investigated. The acute exercise in aerobic group; increase of neutrophiles between (ER) and (Eı.mj„.) were significant (p < 0.05) but increase of lymphocytes were nonsignificant. The decrease of neutrophile and lymphocyte values were found significant (p < 0.05). Anaerobic group show significant increases betvveen ER and Eı-mi„ in the value of leucocyte (%70, p<0.001), lymphocyte (%88, p<0.001), neutrophile (%60, p<0.01), monocyte (%73, p<0.01) and significant decreases betvveen ER and E45.min leucocyte, lymphocyte (%22, p<0.01), monocyte (%7, p<0.05). The subsets of lymphocyte that CD3+, CD4+, CD8+, CD19+ counts decreased in aerobic group in ER according to Eı.rain, CD56+(%35, p<0.01) increased. CD3+, CD4+, CD8+, CD19+ values in anaerobic group decreased in ER according to Eı.min, but CD56+(%77, p<0.001) increased. There was no chan-ges in the ratio of CD4+/CD8+ in aerobic group at Eı_mjn and the ratio changes inversily in anaerobic group. Statistical analysis were done by Manova Test
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Abstract (Original Language): 
Egzersiz vücudun maruz kaldığı en büyük stresdir. Vücut bu strese metabolik, hormonal ve immünolojik sistemlerindeki bir takım fizyolojik değişimlerle cevap verir. Biz bu çalışmamızda akut aero-bik-anaerobik egzersizlere immun sistemin verdiği cevapları göstermeyi amaçladık. Bu çalışmaya 24 erkek sedanter üniversite öğrencisi ve çalışanı alındı. Denekler aerobik ve anacro-bik olmak üzere onikişer kişilik iki gruba ayrıldı. Her iki grubunda fizik muayene, istirahat EKG' si, solunum fonksiyon testleri ve breath by breafh yöntemiyle metabolik tam kondüsyon testleri yapıldı. Anaerobik eşik değerdeki kalp hızları tesbit edildikten sonra, aerobik grup, eşik altı kalp hızında ve Max. VCh'nin %50'sinde 30 dk, anaerobik grup, eşik üstü kalp hızında ve Max. VOVnin %75'inde 20 dk. Monark ergometrik bisikletlerde egzersize tabii tutuldular. Egzersizler esnasında kalp hızları Polar Tester nabız takip cihazı ile takip edildi. Her iki gruptanda egzersiz öncesi(Es), egzersiz sonrası l.dk.(ESON-I.DK.) ve egzersiz sonrası 45.dk.(EsoN-45.DK.)'larda venöz kan örnekleri alındı. Technican H-2 System cihazı ile Hb (gr), Hcl (%), eritrosit (xlOs/mm3), lökosit (xl03/mm3), lökosit formül (% nötrofil, % lenfosit, % monosit, % eozinofil, % bazofil) ve trombosit (xl0'/mm3) değerleri tesbit edildi. Flow Cytometry yöntemiyle monoklonal antikorlarla CD3, CD4, CDs, CD19 ve CD56 tayinleri yapıldı. E8, ESON-I.DK. ve EsoN-45.DK.'da alınan kan örneklerinde egzersizin akut etkisine bakıldı. Egzersizin lökosit sayısı, lökosit alt grupları ve lenfosit alt grupları üzerine etkisine bakıldığında; akut egzersizin, aerobik grupta Es'ne göre ESON-I.DK nötrofillerdeki artış anlamlı (p<0.05), lenfositler-deki artış anlamsız bulunurken, ESON-45.DK.'da nötrofil ve lenfosit değerlerindeki azalma anlamlı (p<0.05) olarak bulunmuştur. Anaerobik grupta Ea'ne göre EsoN-ı.DK'daki artışlar (lökositoz (%70, p<0.001), lenfositoz (%88, p<0.001), nötrofili (%60, p<0.01) ve monositoz (%73, p<0.01)) ve E8'ne göre EsoN-45.DK.'daki azalmalar (lökopeni, lenfopeni (%22, p<0.01) ve nıonositopeni (%7 p<0.05)) anlamlı bulunmuştur. Lenfosit alt gruplarında aerobik grupta Ea'ne göre EsoN-ı.DK'daki CD3, CD4, CDs, CD^da azalma görülürken, CD56 da (%35, p<0.01) artış tespit edilmiştir. Anaerobik grupta Eö'ne göre EsoN-ı.DK'daki CD3, CD4, CD8, CD|9da azalma görülürken, CD56 da (%77, p<0.001) artış tespit edilmiştir. CD4/CD8 oranları EsoN-ı.DK'da aerobik grupta değişmezken anaerobik grupta tersine dönmüştür. Çalışmamızın istatistiksel analizleri Manova testi ile yapılmıştır.
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  • Turkish

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