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Apokrin karsinomun histopatolojik tanısında p63,ün etkinliği; bir aksiller apokrin karsinom olgusu

P63 ın hıstopathologıcal dıagnosıs of apocrıne carcınoma; a case of an axıllary apocrıne carcınoma

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
We report a case of apocrine carcinoma arising in an apocrine adenoma in the axillary region of a 76 year old man. The left axillary skin lesion showed a slow progressive growth for 5 years and was painless. Histological examination revealed the tumor cell nests of various sizes exhibiting papillary and glandular pattern under the overlying epidermis with decapitaton secretion. Non tumoral apocrine and sebaseous glands were found adjacent to the tumor. The carcinoma cells were positive for GCDpP-15. p63, SMA and S-100 positivity were detected in the myoepithelial cells of benign apocrine glands, but the carcinomatous glands were negative for these proteins. On the basis of its histologic and immunohistochemical features and distinctive location, the tumor was diagnosed as apocrine carcinoma. We think that p63 can be used in supporting the diagnosis of the apocrine carcinoma.
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Abstract (Original Language): 
Yetmişaltı yaşında erkek hastanın aksiller bölgesinde apokrin adenomdan gelişen apokrin karsinom olgusu sunulmuştur. Sol aksiller deri lezyonu 5 yıldır yavaş büyümekte olup ağrısızdır. Histolojik incelemede epidermisin altında papiller ve glandüler yapılar oluşturan değişik boyutlarda tümör hücre adaları ile dekapitasyon sekresyonu da izlenmektedir. Tümör komşuluğunda non tümöral apokrin ve sebasöz glandlar bulunmaktadır. Tümör hücreleri "gross cystic disease fluid protein" 15 (GCDpP-15) ile pozitiftir. p63, SMA ve S-100 ile benign apokrin glandların miyoepitelyal hücrelerinde pozitiflik izlenirken, tümörde negatiftir. Olgu tümörün histolojik, immunohistokimyasal bulguları ve yerleşim yerine bağlı olarak apokrin karsinom olarak değerlendirilmiştir. p63'ün apokrin karsinomların tanısını desteklemekte kullanılabileceği düşüncesindeyiz.
FULL TEXT (PDF): 
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  • 4
38-40
  • Turkish

REFERENCES

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