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Otozomal Dominant Polikistik Böbrek Hastalarında Arteriyel Sertlik ile s-Klotho ve FGF23 Düzeyleri Arasındaki İlişki

Relationship Between Arterial Stiffness and s-Klotho, FGF23 Levels in Autosomal Dominant Polycystic Kidney Disease Patients

Journal Name:

Publication Year:

DOI: 
10.17954/amj.2017.76
Abstract (2. Language): 
Objective: In this cross-sectional study, we investigated the relationship between soluble Klotho levels, FGF23 levels and arterial stiffness in Autosomal Dominant Polycystic Kidney Disease patients. Material and Methods: 74 patients (mean age: 50.92 ± 15.70 years) with autosomal Dominant Polycystic Kidney Disease and 32 healthy controls (mean age: 49.53 ± 7.32 years) were included in the study. Blood samples were collected to measure the levels of soluble Klotho, FGF23, serum creatinine, Calcium, Phosphorus and parathyroid hormone. Brachial artery pulse wave velocity and blood pressure were also measured using a combined monitor. Results: Soluble Klotho, FGF23 and parathyroid hormone levels were significantly higher in the patients than in controls (p<0.001). Systolic blood pressure, diastolic blood pressure (p<0.001 and brachial artery pulse wave velocity were also significantly higher in the patients (p=0.022). A positive correlation was found between soluble Klotho and brachial artery pulse wave velocity (r = 0.210, p=0.036) levels and FGF23 and brachial artery pulse wave velocity (r=0.245, p=0.014) levels. Conclusion: Arterial stiffness increased in Autosomal Dominant Polycystic Kidney Disease patients and was related to s-Klotho and FGF23 levels.
Abstract (Original Language): 
Amaç: Bu kesitsel çalışmada; Otozomal Dominant Polikistik Böbrek hastalarında soluble Klotho, FGF23 düzeyleri ile arteriyel sertlik arasındaki ilişki incelenmiştir. Gereç ve Yöntemler: Otozomal Dominant Polikistik Böbrek Hastalığı (ODPBH) tanısı olan 74 hasta (ortalama yaş:50,92±15,70 yıl) ve 32 sağlıklı kontol (ortalama yaş:49,53±7,32 yıl) çalışmaya alınmıştır. Kan örnekleri soluble Klotho, FGF23, serum kreatinin, Kalsiyum, Fosfor ve Parathormon ölçümleri için toplanmıştır. Brakial arter nabız dalga hızı ve kan basıncı aynı monitör kullanılarak ölçülmüştür. Bulgular: Soluble Klotho, FGF23 ve Parathormon düzeyleri hastalarda kontrol grubuna göre anlamlı yüksek saptanmıştır (p<0,001). Aynı zamanda hasta grubunda sistolik kan basıncı, diyastolik kan basıncı (p<0,001) ve brakial arter nabız dalga hızı anlamlı yüksek saptanmıştır (p=0,022). Soluble Klotho ve brakial arter nabız dalga hızı (r = 0,210, p=0,036) düzeyleri, FGF23 ve brakial arter nabız dalga hızı (r=0,245, p=0,014) düzeyleri arasında pozitif korrelasyon saptanmıştır. Sonuç: Otozomal Dominant Polikistik Böbrek hastalarında arteriyel sertlik artar ve soluble Klotho, FGF23 düzeyleri ile ilişkili bulunmuştur.
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