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Prognostic value of clinical and lab parameters in assessing the severity of organophosphorous compound poisoning

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2014

Key Words:

Author Name
Abstract (2. Language): 
Introduction: Respiratory failure is the most common complication of OP poisoning leading to death. Owing to limited availability of resources in India, it is important that clinical features and criteria to predict the need for ventilator support be identified at initial examination. Our aim was to assess the severity of organophosphorus compound poisoning clinically by using Peradeniya scoring and by estimating serum cholinesterase and serum amylase levels. Severity will be predicted in terms of need for ventilator support and dose of atropine needed. Methods: This was an observational study done at H.S.K hospital, a teritary care center at Bagalkot. 60 patients fulfilled inclusion criteria, were included in the study. Results: In this study need for ventilator support was seen in 26.6% of patients. 62.5% of patients with moderate poisoning and 100% of patients with severe poisoning according to POP scale required ventilator support. Serum cholinesterase levels and serum amylase levels also correlated well with need for ventilator support(p value<0.05).Mean dose of atropine required was high in patients with low pche levels(442.67mg), high serum amylase levels(260.33mg) and severe grade on POP scale(584mg) when compared to patients with normal pche levels(72.76mg), amylase levels(86.81), mild grade on POP scale(86.76mg) respectively. Conclusion: Peradeniya OP poisoning scale, serum cholinesterase levels, serum amylase levels all correlated well with severity of poisoning particularly in terms of need for ventilator support and dose of atropine required.
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