Buradasınız

Clinical profile of organophosphorus poisoning in a tertiary care hospital

Journal Name:

Publication Year:

Abstract (2. Language): 
Introduction: Organophosphorus compounds are associated with significant morbidity and mortality in developing countries, predominantly affecting the working age group (21-30 years). Present study was planned to study the clinical profile of organophosphorus poisoning admitted to the Karnataka Institute of Medical Sciences, Hubli. Materials and methods: Patients admitted to Karanataka Institute of Medical Sciences, Hubli, between the December 2011 and November 2012, with history of organophosphorus poisoning were studied, with preformed proforma. Observations and results: Out of 320 patients included in the study, majority were male (58.75%), between the age group of 21-30 years. Most common cause was suicidal (97.5%), commonly affecting farmers (30%), illiterates (42.5%) and from rural area (70%). Most patients were of grade II severity (45%); higher grade associated with higher duration of hospital stay and death. Most common finding pupillary constriction (76.25%), followed by excessive secretions (57.5%). Mortality rate in our study was 21.25%. Dimethoate was the most common poison (18.75%). Monocrotophos poisoning and dicholorovas poisoning was associated with higher mortality of 100% and 66.63% respectively. Conclusion: Organophosphorus poisoning has become a common mode of suicide in the rural setting, among the farmers and the illiterates. The ease of availability of the poison and the poor health care facility has caused a higher mortality rate. Selective ban on poison compound with high mortality rate and availability of proper health care facility is a need of the hour.
14
22

REFERENCES

References: 

1. Murat S, Guiven M. Intensive care management of organophosphate insecticide poisoning. Crit
Care 2001;5(4):211-215
2. M. Eddlestron, L. Szinicz, P.Eyer. Oximes in acute organophosphorous poisoning: a systematic
review of clinical trials. QJ Med.J. 2002; 275 – 283
3. Cherian MA, Roshini C, Visalakshi J. Biochemical and Clinical Profile After Organophosphorus
Poisonning – A Placebo – Controlled Trial using Pralidoxime. JAP1 May 2005; 53: 427-430
4. Berger LR. Suicides and pesticides in Sri Lanka. Am J Public Health, 1988;78:826-827
5. Guven M, Dogukan A, Taskapan H. Lcukocytosis as a parameter in Management of
Organophosphate Intoxication Turk J Med Sci 2000;30:499-500
6. T Dassanayake, V Weerasinghe, U Dangahadeniya, K Kularatne, A Dawson, L Karalliedde,et al.
Clinical Neurophysiology, 2008;119:144-150
7. Saadeh AM, Farsakh NA, Ali MK. Cardiac manifestations of acute carbonate and
organophosphate poisoning . Heart 1997; 77: 461-464
8. Otto KR, Spate HF. Suicidal trends in Urban and rural districts of Brandenburg. Psychiatri Neuro
Med Psychol. 1975;27(4):239-46
9. Dalal JS, Gorea RK, Aggarwal AK, Thind AS and Sandhu SS. Poisoning Trends- A postmortem
study. Journal of Indian Academy of Forensic Medicine 1998;20(2):27-31
10. Singh S et al. Parathion poisoning in Punjab. JAPI 1969;17:181-187
11. Kamath PG, Dalgi AJ and Patel BM. Diazinon poisoning. JAPI 1964;14:477-481
Indian Journal of Basic and Applied Medical Research; December 2014: Vol.-4, Issue- 1, P. 14-22
22
www.ijbamr.com P ISSN: 2250-284X , E ISSN : 2250-2858
12. Gupta B et al. Organophosphorus poisoning facts and myths. Medicine Update, 1999;1345-1348
13. Vishwanathan M and Srinivasan. Poisoning by bug poison. JIMA, 1962; 39(7): 345-349.
14. Doshi JC, MK Katakia and HM Baxamusa. Organophosphorus poisoning. Journal of Postgraduate
Medicine; 11(2): 1964
15. Thunga G et al. Evaluation of incidence, clinical characteristics and management in
organophosphorus poisoning cases in a tertiary care hospital. Journal of Toxicology and
Environmental Health Sciences 2010; 2(5):73-76
16. Arup KK et al. Predictors of mortality in OP poisoning- Hospital based study from suburban West
Bengal. JAPI 2001; 49:91

Thank you for copying data from http://www.arastirmax.com