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Sistemik Lupus Eritematozusta immunoglobulin Düzeyleri: IgA Aktivite Kriteri mi?

Serum Immunoglobuli n Levels in Systemic Lupus Erythematosus: Is IgA Level an Activity Criterion?

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
IgG and IgA levels are found to be elevated in systemic lupus erythematosus (SLE) in several studies. In this study, we measured the immunoglobulin levels of the patients with SLE in both activation and remission periods, and tried to determine if the IgA levels can be used as an activity criterion. We also tried to determine the rate of the selective IgA deficiency in a large population of SLE patients and correlation of these findings with other laboratory and clinical parameters. The findings from these patients with SLE suggest that: 1) IgG and IgA levels are elevated in activation periods. 2) IgG levels remains elevated in remission periods. 3) Elevation IgG levels could be a indicator of activity of SLE, but since it remains elevated in remission periods, standardization could not be possible. 4) Elevation of IgA levels could not be an activation criterion. Also, the selective IgA deficiency was seen 1.76% of the SLE patients with activation and 2.15% of the SLE patients in remission period. There was no negative or positive correlation between the selective IgA deficiency and renal involvement, or other laboratory and clinical parameters
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Abstract (Original Language): 
Sistemik Lupus Eritematozus'ta (SLE), özellikle IgG ve IgA serum düzeylerinde artış birçok çalışmada gösterilmiştir. Bu çalışmada SLE'li hastalarda hem aktif hem de remisyon dönemlerinde immunoglobulin düzeylerini ölçerek, özellikle serum IgA konsantrasyonunun aktivite kriteri olup olamayacağını, ek olarak geniş bir SLE serisinde selektif IgA yetmezliğinin oranını ve bunların diğer laboratuar ve klinik parametreleriyle korelasyonunu araştırdık. SLE'li hasta gruplarından elde ettiğimiz sonuçlarla, SLE' de; 1) Aktif dönemde IgG ve IgA'da artış görüldüğünü, 2) Remisyonda sadece IgG'nin arttığını, 3) IgG'nin aktivite kriteri olabileceğini ancak remisyon dönemlerinde de arttığı için standartizasyonun mümkün olamayacağını, 4) IgA yüksekliğinin aktivite kriteri olamayacağını gösterdik. Ayrıca çalışmamızda literatürle uyumlu olarak selektif IgA eksikliği, aktif SLE'li hasta grubunda %1.76, remisyonda olan SLE'li hasta grubunda %2.15 olarak bulundu. Selektif IgA eksikliği ile böbrek tutulumu, herhangi bir laboratuar ve klinik parametre yada tedavi modeli arasında, pozitif veya negatif bir korelasyon gösterilemedi.
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  • 4
336-342
  • Turkish

REFERENCES

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