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RANİTİDİN UYGULANMASINI TAKİBEN SIÇANLARIN PANETH HÜCRELERİNİN HİSTOLOJİK İNCELENMESİ

Histological Observation Of The Paneth Cells Following Ranitidin Induction in Rats

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Ranitidin is a blocking agent for histamine H2 receptors that changes pH of the chyme. Bacteria do not live in the acidic miliue. Bacteria pass through the intestine by way of changing the pH of the miliue. Especially, Paneth cells are replaced at the distal lleum region of the intestine and manufacture the antibacterial agent lysozyme, protecting the intestinal flora by discharging the granules containing lysozyme. Yazışma adresi: Dr. Leyl a CANPOLAT Fırat Üniversitesi Tıp Fakültesi Histoloji- Embriyoloji Bölümü ELAZIĞ Aim: The Paneth cell changes are examined histologically, to assure miliue permission to the bacterial living by use of H2 receptor blocking. In this study, the Paneth cells had been assigned to degranulation by way of increasing cellular activity.
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Abstract (Original Language): 
Ranttidin mide içeriğinin (kimus) pH'ını değiştiren H2 reseptör blokörüdür. Ortamın asidik olması bakterisid etkiyi azaltır. Asidik ortamda bakteri yaşayamaz. Ortamın pH'ını değiştiren ranitidin nedeniyle bakteriler barsak ortamına rahatça girerler. Özeliikle ince barsağın ileum parçasında barsak florasının korunmasında rol oynayan Paneth hücrelerinin, iizozim içeren salgı granüllerini boşaltarak, bakterisid etkiyi ortadan kaldırmaya çahştığı binmektedir. Amaç, ranitidinin H2 reseptör blokör özeliğinden yararlanıp, kimusun bakteri yaşamasına izin veren alkali ortamını oluşturarak, Paneth hücre/erindeki değişiklikleri histolojik olarak incelemektir. Ya-plan çaişmada, Paneth hücrelerinin aktif/eşip, aktivitesini artırıp, de-granülasyona uğradığı saptanmıştır.
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  • 4
297-300
  • Turkish

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