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DEVELOPMENT AND VALIDATION OF DUAL WAVELENGTH UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TADALAFIL AND DAPOXETINE HYDROCHLORIDE IN THEIR COMBINED TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical dual wavelength spectrophotometric method for the simultaneous determination of Tadalafil and Dapoxetine Hydrochloride in combined tablet dosage form. The principle for dual wavelength method is "the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest". The method was based on determination of Dapoxetine Hydrochloride at the absorbance difference between 280.0 nm and 295.4 nm and Tadalafil at the absorbance difference between 255.0 nm and 298.2 nm. The linearity was obtained in the concentration range of 4-24 ug/ml and 10-60 ug/ml for Tadalafil and Dapoxetine Hydrochloride respectively. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The suitability of these methods for the quantitative determination of Tadalafil and Dapoxetine Hydrochloride was proved by validation and recovery study. The proposed methods were found to be simple and sensitive for the routine quality control application ofTadalafil and Dapoxetine Hydrochloride in pharmaceutical tablet dosage form.
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  • 2
  • English

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