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FORMULATION AN D EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF CANDESARTAN CILEXETIL

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
To formulate and evaluate the sustained release matrix tablet of Candesartan cilexetil using different ratio of hydrophilic and hydrophobic polymers in order to increase the drug bioavailability, therapeutic efficiency, reduce dosing frequency and improvement of patient compliance. Different formulations were prepared by wet granulation method using various release rate controlling hydrophilic polymer like HPMC K 15M, HPMC K 100M and hydrophobic polymers like ethyl cellulose. Drug-excipients compatibility was carried out by FTIR. Different formulations were evaluated for hardness, thickness, friability, swelling index, drug content and in vitro drug release. Mathematical analysis of the release kinetics was carried out to determine the mechanism of drug release. In vitro release data was fitted to various models to ascertain the kinetic of drug release. Response surface graph was prepared to examine the effect of independent variable on dependent variable.
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  • English

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